| UniProt ID | THAP3_HUMAN | |
|---|---|---|
| UniProt AC | Q8WTV1 | |
| Protein Name | THAP domain-containing protein 3 | |
| Gene Name | THAP3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 239 | |
| Subcellular Localization | ||
| Protein Description | Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1.. | |
| Protein Sequence | MPKSCAARQCCNRYSSRRKQLTFHRFPFSRPELLKEWVLNIGRGNFKPKQHTVICSEHFRPECFSAFGNRKNLKHNAVPTVFAFQDPTQQVRENTDPASERGNASSSQKEKVLPEAGAGEDSPGRNMDTALEELQLPPNAEGHVKQVSPRRPQATEAVGRPTGPAGLRRTPNKQPSDHSYALLDLDSLKKKLFLTLKENEKLRKRLQAQRLVMRRMSSRLRACKGHQGLQARLGPEQQS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 122 | Phosphorylation | EAGAGEDSPGRNMDT CCCCCCCCCCCCHHH | 25.59 | 23401153 | |
| 149 | Ubiquitination | GHVKQVSPRRPQATE CCCCCCCCCCCCHHH | 37.13 | 22817900 | |
| 153 | Ubiquitination | QVSPRRPQATEAVGR CCCCCCCCHHHHCCC | 60.13 | 22817900 | |
| 170 | Phosphorylation | GPAGLRRTPNKQPSD CCCCCCCCCCCCCCC | 25.44 | 27050516 | |
| 196 | Ubiquitination | KKKLFLTLKENEKLR HHHHHHHHHHHHHHH | 7.72 | 22817900 | |
| 196 (in isoform 3) | Ubiquitination | - | 7.72 | 21906983 | |
| 197 | Ubiquitination | KKLFLTLKENEKLRK HHHHHHHHHHHHHHH | 53.94 | 22817900 | |
| 197 (in isoform 1) | Ubiquitination | - | 53.94 | 21906983 | |
| 200 | Ubiquitination | FLTLKENEKLRKRLQ HHHHHHHHHHHHHHH | 55.34 | 22817900 | |
| 201 | Ubiquitination | LTLKENEKLRKRLQA HHHHHHHHHHHHHHH | 66.24 | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of THAP3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of THAP3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of THAP3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| HCFC1_HUMAN | HCFC1 | physical | 20200153 | |
| OGT1_HUMAN | OGT | physical | 20200153 | |
| A4_HUMAN | APP | physical | 21832049 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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