dbPTM

TNIK_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TNIK_HUMAN
UniProt AC	Q9UKE5
Protein Name	TRAF2 and NCK-interacting protein kinase
Gene Name	TNIK
Organism	Homo sapiens (Human).
Sequence Length	1360
Subcellular Localization	Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.
Protein Description	Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322..
Protein Sequence	MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	ASDSPARSLDEIDLS CCCCCCCCCCCCCHH	42.13	21406692
16	Phosphorylation	SLDEIDLSALRDPAG CCCCCCHHHHCCCCH	22.85	21406692
16 (in isoform 4)	Phosphorylation	-	22.85	21406692
36	Phosphorylation	ELVGNGTYGQVYKGR EECCCCCCCEEECCC	13.63	25884760
40	Phosphorylation	NGTYGQVYKGRHVKT CCCCCEEECCCCCCC	10.39	18452278
46	Ubiquitination	VYKGRHVKTGQLAAI EECCCCCCCCCEEEE	40.59	-
84	Phosphorylation	SHHRNIATYYGAFIK CCHHCHHHHCCCHHH	17.30	24076635
85	Phosphorylation	HHRNIATYYGAFIKK CHHCHHHHCCCHHHH	7.29	29083192
86	Phosphorylation	HRNIATYYGAFIKKN HHCHHHHCCCHHHHC	9.53	25839225
121	Ubiquitination	TDLIKNTKGNTLKEE HHHHHCCCCCCCCHH	60.60	-
155	Ubiquitination	KVIHRDIKGQNVLLT CEECCCCCCCEEEEC	59.75	30230243
175	Phosphorylation	KLVDFGVSAQLDRTV EEEEECCEEECCCCC	15.63	30576142
181	Phosphorylation	VSAQLDRTVGRRNTF CEEECCCCCCCCCCC	27.29	30266825
187	Phosphorylation	RTVGRRNTFIGTPYW CCCCCCCCCCCCCCC	18.15	22322096
191	Phosphorylation	RRNTFIGTPYWMAPE CCCCCCCCCCCCCCC	14.37	28450419
193	Phosphorylation	NTFIGTPYWMAPEVI CCCCCCCCCCCCCEE	13.98	28450419
264	Phosphorylation	KWSKKFQSFIESCLV HHHHHHHHHHHHHHC	31.18	28857561
268	Phosphorylation	KFQSFIESCLVKNHS HHHHHHHHHHCCCCC	14.13	24719451
303	Ubiquitination	RQVRIQLKDHIDRTK CEEHHHHHHHHHHHH	30.77	30230243
319	Phosphorylation	KRGEKDETEYEYSGS HCCCCCCCCEECCCC	54.74	18691976
319 (in isoform 4)	Phosphorylation	-	54.74	21406692
321	Phosphorylation	GEKDETEYEYSGSEE CCCCCCCEECCCCHH	27.82	18691976
323	Phosphorylation	KDETEYEYSGSEEEE CCCCCEECCCCHHHH	19.89	25850435
324	Phosphorylation	DETEYEYSGSEEEEE CCCCEECCCCHHHHC	24.73	22115753
324 (in isoform 4)	Phosphorylation	-	24.73	21406692
326	Phosphorylation	TEYEYSGSEEEEEEN CCEECCCCHHHHCCC	35.57	22115753
326 (in isoform 4)	Phosphorylation	-	35.57	21406692
335	Phosphorylation	EEEEENDSGEPSSIL HHHCCCCCCCCCHHC	57.55	25850435
339	Phosphorylation	ENDSGEPSSILNLPG CCCCCCCCHHCCCCC	26.21	21406692
340	Phosphorylation	NDSGEPSSILNLPGE CCCCCCCHHCCCCCC	41.64	21406692
348	Phosphorylation	ILNLPGESTLRRDFL HCCCCCCCHHHHHHH	38.36	21406692
349	Phosphorylation	LNLPGESTLRRDFLR CCCCCCCHHHHHHHH	21.71	21406692
365	Phosphorylation	QLANKERSEALRRQQ HHHCHHHHHHHHHHH	28.45	27470641
427	Phosphorylation	EREQRRHYEEQMRRE HHHHHHHHHHHHHHH	21.25	-
446	Phosphorylation	RAEHEQEYIRRQLEE HHHHHHHHHHHHHHH	10.22	-
475	Phosphorylation	EQALLLEYKRKQLEE HHHHHHHHHHHHHHH	18.96	-
476	Ubiquitination	QALLLEYKRKQLEEQ HHHHHHHHHHHHHHH	43.68	30230243
499	Phosphorylation	QLKQERDYLVSLQHQ HHHHHHHHHHHHHHH	18.41	29978859
502	Phosphorylation	QERDYLVSLQHQRQE HHHHHHHHHHHHHHH	21.51	30108239
519	Phosphorylation	PVEKKPLYHYKEGMS CCCCCCCCCCCCCCC	16.19	28270605
521	Phosphorylation	EKKPLYHYKEGMSPS CCCCCCCCCCCCCCC	9.36	28270605
526	Phosphorylation	YHYKEGMSPSEKPAW CCCCCCCCCCCCCHH	35.81	28348404
528	Phosphorylation	YKEGMSPSEKPAWAK CCCCCCCCCCCHHHH	51.44	30108239
541	Phosphorylation	AKEVEERSRLNRQSS HHHHHHHHHHHCCCC	44.38	26437602
547	Phosphorylation	RSRLNRQSSPAMPHK HHHHHCCCCCCCCHH	34.74	23403867
548	Phosphorylation	SRLNRQSSPAMPHKV HHHHCCCCCCCCHHH	14.35	27794612
556	Phosphorylation	PAMPHKVANRISDPN CCCCHHHHHHCCCCC	12.37	33259812
560	Phosphorylation	HKVANRISDPNLPPR HHHHHHCCCCCCCCC	43.72	30266825
568	O-linked_Glycosylation	DPNLPPRSESFSISG CCCCCCCCCCCCCCC	43.28	28657654
568	Phosphorylation	DPNLPPRSESFSISG CCCCCCCCCCCCCCC	43.28	29255136
570	Phosphorylation	NLPPRSESFSISGVQ CCCCCCCCCCCCCCC	26.07	29255136
572	Phosphorylation	PPRSESFSISGVQPA CCCCCCCCCCCCCCC	25.73	29255136
574	Phosphorylation	RSESFSISGVQPART CCCCCCCCCCCCCCC	31.54	21082442
581	Phosphorylation	SGVQPARTPPMLRPV CCCCCCCCCCCCCCC	33.57	29255136
585	Phosphorylation	PARTPPMLRPVDPQI CCCCCCCCCCCCCCC	7.45	33259812
600	Phosphorylation	PHLVAVKSQGPALTA CCEEEECCCCCCEEC	33.50	29496963
606	Phosphorylation	KSQGPALTASQSVHE CCCCCCEECCCCHHC	26.77	29978859
608	Phosphorylation	QGPALTASQSVHEQP CCCCEECCCCHHCCC	20.11	23401153
610	Phosphorylation	PALTASQSVHEQPTK CCEECCCCHHCCCCC	23.97	29507054
611	Phosphorylation	ALTASQSVHEQPTKG CEECCCCHHCCCCCC	4.46	33259812
616	Phosphorylation	QSVHEQPTKGLSGFQ CCHHCCCCCCCCHHH	37.12	29978859
620	Phosphorylation	EQPTKGLSGFQEALN CCCCCCCCHHHHHHH	46.35	27470641
629	Phosphorylation	FQEALNVTSHRVEMP HHHHHHCCCCCEECC	20.10	27470641
630	Phosphorylation	QEALNVTSHRVEMPR HHHHHCCCCCEECCC	12.67	27251275
640	Phosphorylation	VEMPRQNSDPTSENP EECCCCCCCCCCCCC	36.31	29255136
640 (in isoform 4)	Phosphorylation	-	36.31	21406692
643	Phosphorylation	PRQNSDPTSENPPLP CCCCCCCCCCCCCCC	54.38	30266825
643 (in isoform 4)	Phosphorylation	-	54.38	21406692
644	Phosphorylation	RQNSDPTSENPPLPT CCCCCCCCCCCCCCC	40.54	30266825
651	Phosphorylation	SENPPLPTRIEKFDR CCCCCCCCHHHHCCH	52.54	23403867
659	Phosphorylation	RIEKFDRSSWLRQEE HHHHCCHHHHHHCCC	27.92	29449344
660	Phosphorylation	IEKFDRSSWLRQEED HHHCCHHHHHHCCCC	30.90	27470641
676	Phosphorylation	PPKVPQRTTSISPAL CCCCCCCCCCCCHHH	21.46	23927012
676 (in isoform 4)	Phosphorylation	-	21.46	21406692
677	Phosphorylation	PKVPQRTTSISPALA CCCCCCCCCCCHHHH	26.67	29255136
678	Phosphorylation	KVPQRTTSISPALAR CCCCCCCCCCHHHHC	22.06	29255136
678 (in isoform 4)	Phosphorylation	-	22.06	21406692
680	Phosphorylation	PQRTTSISPALARKN CCCCCCCCHHHHCCC	12.14	19664994
680 (in isoform 4)	Phosphorylation	-	12.14	21406692
685	Phosphorylation	SISPALARKNSPGNG CCCHHHHCCCCCCCC	39.27	32142685
688	Phosphorylation	PALARKNSPGNGSAL HHHHCCCCCCCCCCC	36.90	23401153
688 (in isoform 4)	Phosphorylation	-	36.90	21406692
693	Phosphorylation	KNSPGNGSALGPRLG CCCCCCCCCCCCCCC	25.07	23403867
693 (in isoform 4)	Phosphorylation	-	25.07	21406692
698	Methylation	NGSALGPRLGSQPIR CCCCCCCCCCCCCCC	50.29	115918673
701	Phosphorylation	ALGPRLGSQPIRASN CCCCCCCCCCCCCCC	37.06	23401153
705	Methylation	RLGSQPIRASNPDLR CCCCCCCCCCCCCCC	38.35	115918677
707	Phosphorylation	GSQPIRASNPDLRRT CCCCCCCCCCCCCCC	38.76	29255136
714	Phosphorylation	SNPDLRRTEPILESP CCCCCCCCCCCCCCC	39.41	32142685
720	Phosphorylation	RTEPILESPLQRTSS CCCCCCCCCCCCCCC	27.71	23401153
725	Phosphorylation	LESPLQRTSSGSSSS CCCCCCCCCCCCCCC	17.81	28450419
725	Ubiquitination	LESPLQRTSSGSSSS CCCCCCCCCCCCCCC	17.81	30230243
726	Phosphorylation	ESPLQRTSSGSSSSS CCCCCCCCCCCCCCC	34.59	28450419
727	Phosphorylation	SPLQRTSSGSSSSSS CCCCCCCCCCCCCCC	41.92	26434776
729	Phosphorylation	LQRTSSGSSSSSSTP CCCCCCCCCCCCCCC	29.06	28450419
730	Phosphorylation	QRTSSGSSSSSSTPS CCCCCCCCCCCCCCC	37.45	28450419
731	Phosphorylation	RTSSGSSSSSSTPSS CCCCCCCCCCCCCCC	35.62	28450419
732	Phosphorylation	TSSGSSSSSSTPSSQ CCCCCCCCCCCCCCC	30.20	28450419
732	Ubiquitination	TSSGSSSSSSTPSSQ CCCCCCCCCCCCCCC	30.20	30230243
733	Phosphorylation	SSGSSSSSSTPSSQP CCCCCCCCCCCCCCC	39.93	25262027
734	Phosphorylation	SGSSSSSSTPSSQPS CCCCCCCCCCCCCCC	46.41	25262027
735	Phosphorylation	GSSSSSSTPSSQPSS CCCCCCCCCCCCCCC	29.19	25262027
737	Phosphorylation	SSSSSTPSSQPSSQG CCCCCCCCCCCCCCC	41.51	28450419
738	Phosphorylation	SSSSTPSSQPSSQGG CCCCCCCCCCCCCCC	47.52	25262027
740	Phosphorylation	SSTPSSQPSSQGGSQ CCCCCCCCCCCCCCC	37.58	32142685
740	Ubiquitination	SSTPSSQPSSQGGSQ CCCCCCCCCCCCCCC	37.58	30230243
741	Phosphorylation	STPSSQPSSQGGSQP CCCCCCCCCCCCCCC	27.88	25262027
742	Phosphorylation	TPSSQPSSQGGSQPG CCCCCCCCCCCCCCC	39.26	25262027
746	Phosphorylation	QPSSQGGSQPGSQAG CCCCCCCCCCCCCCC	39.77	28450419
750	Phosphorylation	QGGSQPGSQAGSSER CCCCCCCCCCCCCCC	24.44	25262027
754	Phosphorylation	QPGSQAGSSERTRVR CCCCCCCCCCCCCCC	31.85	30576142
754	Ubiquitination	QPGSQAGSSERTRVR CCCCCCCCCCCCCCC	31.85	30230243
755	Phosphorylation	PGSQAGSSERTRVRA CCCCCCCCCCCCCCC	30.13	28450419
758	Phosphorylation	QAGSSERTRVRANSK CCCCCCCCCCCCCCC	29.48	30576142
761	Ubiquitination	SSERTRVRANSKSEG CCCCCCCCCCCCCCC	25.43	30230243
764	Phosphorylation	RTRVRANSKSEGSPV CCCCCCCCCCCCCCC	36.25	29255136
766	Phosphorylation	RVRANSKSEGSPVLP CCCCCCCCCCCCCCC	47.19	29255136
766 (in isoform 4)	Phosphorylation	-	47.19	21406692
769	Phosphorylation	ANSKSEGSPVLPHEP CCCCCCCCCCCCCCC	14.05	29255136
769	Ubiquitination	ANSKSEGSPVLPHEP CCCCCCCCCCCCCCC	14.05	30230243
769 (in isoform 4)	Phosphorylation	-	14.05	21406692
780	Ubiquitination	PHEPAKVKPEESRDI CCCCCCCCHHHHCCC	46.11	30230243
787	Ubiquitination	KPEESRDITRPSRPA CHHHHCCCCCCCCCH	3.23	30230243
788	Phosphorylation	PEESRDITRPSRPAS HHHHCCCCCCCCCHH	40.59	30108239
791	Phosphorylation	SRDITRPSRPASYKK HCCCCCCCCCHHHHH	47.83	26657352
795	Phosphorylation	TRPSRPASYKKAIDE CCCCCCHHHHHHHHH	39.92	30108239
795	Ubiquitination	TRPSRPASYKKAIDE CCCCCCHHHHHHHHH	39.92	30230243
796	Phosphorylation	RPSRPASYKKAIDED CCCCCHHHHHHHHHH	20.72	27251275
805	Phosphorylation	KAIDEDLTALAKELR HHHHHHHHHHHHHHH	31.76	27470641
809	Ubiquitination	EDLTALAKELRELRI HHHHHHHHHHHHHHH	59.12	30230243
816	Ubiquitination	KELRELRIEETNRPM HHHHHHHHHHHCCCC	9.79	30230243
819	Phosphorylation	RELRIEETNRPMKKV HHHHHHHHCCCCCCC	24.60	27470641
824	Acetylation	EETNRPMKKVTDYSS HHHCCCCCCCCCCCC	46.93	19818187
824	Ubiquitination	EETNRPMKKVTDYSS HHHCCCCCCCCCCCC	46.93	30230243
827	Phosphorylation	NRPMKKVTDYSSSSE CCCCCCCCCCCCCCC	37.79	30576142
830	Phosphorylation	MKKVTDYSSSSEESE CCCCCCCCCCCCCCC	26.93	19369195
831	Phosphorylation	KKVTDYSSSSEESES CCCCCCCCCCCCCCC	31.49	19369195
832	Phosphorylation	KVTDYSSSSEESESS CCCCCCCCCCCCCCC	35.51	30576142
833	Phosphorylation	VTDYSSSSEESESSE CCCCCCCCCCCCCCC	47.53	19369195
836	Phosphorylation	YSSSSEESESSEEEE CCCCCCCCCCCCCHH	38.43	24076635
838	Phosphorylation	SSSEESESSEEEEED CCCCCCCCCCCHHCC	52.94	19369195
839	Phosphorylation	SSEESESSEEEEEDG CCCCCCCCCCHHCCC	45.00	19369195
850	Phosphorylation	EEDGESETHDGTVAV HCCCCCCCCCCEEEH	34.25	30576142
892	Phosphorylation	LETSHADSFSGSISR CCCCCCCCCCCCCCC	23.30	28060719
894	Phosphorylation	TSHADSFSGSISREG CCCCCCCCCCCCCCE	35.27	27080861
896	Phosphorylation	HADSFSGSISREGTL CCCCCCCCCCCCEEE	19.05	27080861
898	Phosphorylation	DSFSGSISREGTLMI CCCCCCCCCCEEEEE	26.44	27080861
902	Phosphorylation	GSISREGTLMIRETS CCCCCCEEEEEEECC	14.38	28060719
915	Phosphorylation	TSGEKKRSGHSDSNG CCCCCCCCCCCCCCC	50.14	18691976
918	Phosphorylation	EKKRSGHSDSNGFAG CCCCCCCCCCCCCCC	46.38	27080861
920	Phosphorylation	KRSGHSDSNGFAGHI CCCCCCCCCCCCCCC	41.70	27080861
936	Phosphorylation	LPDLVQQSHSPAGTP HHHHHHCCCCCCCCC	14.61	29523821
938	Phosphorylation	DLVQQSHSPAGTPTE HHHHCCCCCCCCCCC	22.99	29523821
942	Phosphorylation	QSHSPAGTPTEGLGR CCCCCCCCCCCCCCC	29.19	29523821
944	Phosphorylation	HSPAGTPTEGLGRVS CCCCCCCCCCCCCCC	42.39	29523821
951	Phosphorylation	TEGLGRVSTHSQEMD CCCCCCCCCCCCCCC	21.02	23403867
952	Phosphorylation	EGLGRVSTHSQEMDS CCCCCCCCCCCCCCC	23.77	23403867
954	Phosphorylation	LGRVSTHSQEMDSGT CCCCCCCCCCCCCCC	28.11	23403867
959	Phosphorylation	THSQEMDSGTEYGMG CCCCCCCCCCCCCCC	46.43	23403867
961	Phosphorylation	SQEMDSGTEYGMGSS CCCCCCCCCCCCCCC	29.95	23403867
963	Phosphorylation	EMDSGTEYGMGSSTK CCCCCCCCCCCCCCC	16.55	25884760
967	Phosphorylation	GTEYGMGSSTKASFT CCCCCCCCCCCCCCC	26.41	23403867
968	Phosphorylation	TEYGMGSSTKASFTP CCCCCCCCCCCCCCC	28.35	23403867
969	Phosphorylation	EYGMGSSTKASFTPF CCCCCCCCCCCCCCC	32.12	23403867
972	Phosphorylation	MGSSTKASFTPFVDP CCCCCCCCCCCCCCC	31.07	25850435
974	Phosphorylation	SSTKASFTPFVDPRV CCCCCCCCCCCCCCE	17.20	25850435
982	Phosphorylation	PFVDPRVYQTSPTDE CCCCCCEEECCCCCC	13.83	30108239
984	Phosphorylation	VDPRVYQTSPTDEDE CCCCEEECCCCCCCC	20.98	28450419
985	Phosphorylation	DPRVYQTSPTDEDEE CCCEEECCCCCCCCC	15.41	30108239
987	Phosphorylation	RVYQTSPTDEDEEDE CEEECCCCCCCCCCH	52.36	26657352
996	Phosphorylation	EDEEDEESSAAALFT CCCCCHHHHHHHHHH	24.19	29496963
997	Phosphorylation	DEEDEESSAAALFTS CCCCHHHHHHHHHHH	25.80	28450419
1003	Phosphorylation	SSAAALFTSELLRQE HHHHHHHHHHHHHHH	23.34	27732954
1021	Phosphorylation	LNEARKISVVNVNPT HHHCCCEEEEECCCC	24.05	26657352
1028	Phosphorylation	SVVNVNPTNIRPHSD EEEECCCCCCCCCCC	37.77	28985074
1034	Phosphorylation	PTNIRPHSDTPEIRK CCCCCCCCCCHHHHH	45.95	18691976
1036	Phosphorylation	NIRPHSDTPEIRKYK CCCCCCCCHHHHHHH	26.32	17192257
1039 (in isoform 8)	Ubiquitination	-	4.91	21890473
1047 (in isoform 5)	Ubiquitination	-	42.65	21890473
1076 (in isoform 3)	Ubiquitination	-	50.18	21890473
1086	Ubiquitination	VYNLINRRRFQQMDV HHHHHHCCCCCCCHH	39.00	29967540
1094	Ubiquitination	RFQQMDVLEGLNVLV CCCCCHHHHCCCEEE	3.63	29967540
1102 (in isoform 2)	Ubiquitination	-	12.79	21890473
1113	Phosphorylation	KKNKLRVYYLSWLRN CCCEEEEEEHHHHHH	7.70	25690035
1115	Ubiquitination	NKLRVYYLSWLRNRI CEEEEEEHHHHHHHH	1.30	29967540
1116	Phosphorylation	KLRVYYLSWLRNRIL EEEEEEHHHHHHHHH	14.14	23403867
1123	Ubiquitination	SWLRNRILHNDPEVE HHHHHHHHHCCHHHH	2.52	29967540
1131	Ubiquitination	HNDPEVEKKQGWITV HCCHHHHHHCCCEEE	56.42	-
1131 (in isoform 1)	Ubiquitination	-	56.42	21890473
1138 (in isoform 4)	Ubiquitination	-	4.06	21890473
1141	Ubiquitination	GWITVGDLEGCIHYK CCEEEECCCCCEEEE	5.12	29967540
1149	Ubiquitination	EGCIHYKVVKYERIK CCCEEEEEEEHHHHC	3.37	29967540
1170	Ubiquitination	KNAVEIYAWAPKPYH HCCHHHEEECCCCHH	11.13	29967540
1178	Ubiquitination	WAPKPYHKFMAFKSF ECCCCHHCHHHHHCH	30.87	29967540
1227	Ubiquitination	VDSGNSYDIYIPSHI CCCCCEEEEECCCCC	27.34	21890473
1227 (in isoform 8)	Ubiquitination	-	27.34	21890473
1233	Ubiquitination	YDIYIPSHIQGNITP EEEECCCCCCCCCCC	15.84	23000965
1235	Ubiquitination	IYIPSHIQGNITPHA EECCCCCCCCCCCCE	33.19	21890473
1235 (in isoform 5)	Ubiquitination	-	33.19	21890473
1241	Ubiquitination	IQGNITPHAIVILPK CCCCCCCCEEEEEEC	21.31	23000965
1256	Ubiquitination	TDGMEMLVCYEDEGV CCCCEEEEEEECCCE	2.93	21890473
1256 (in isoform 7)	Ubiquitination	-	2.93	21890473
1262	Ubiquitination	LVCYEDEGVYVNTYG EEEEECCCEEEECCC	28.51	23000965
1264	Phosphorylation	CYEDEGVYVNTYGRI EEECCCEEEECCCCC	9.99	-
1264	Ubiquitination	CYEDEGVYVNTYGRI EEECCCEEEECCCCC	9.99	21890473
1264 (in isoform 3)	Ubiquitination	-	9.99	21890473
1267	Phosphorylation	DEGVYVNTYGRITKD CCCEEEECCCCCCCC	19.80	-
1270	Ubiquitination	VYVNTYGRITKDVVL EEEECCCCCCCCCHH	24.00	23000965
1282	Ubiquitination	VVLQWGEMPTSVAYI CHHHCCCCCCEEEEE	3.75	21890473
1282 (in isoform 6)	Ubiquitination	-	3.75	21890473
1288	Ubiquitination	EMPTSVAYIHSNQIM CCCCEEEEEECCCCC	9.30	23000965
1290	Ubiquitination	PTSVAYIHSNQIMGW CCEEEEEECCCCCCC	14.18	21890473
1290 (in isoform 2)	Ubiquitination	-	14.18	21890473
1296	Ubiquitination	IHSNQIMGWGEKAIE EECCCCCCCCCCEEE	30.76	23000965
1311	Ubiquitination	IRSVETGHLDGVFMH EEEECCCCCCEEEHH	28.32	21890473
1317	Ubiquitination	GHLDGVFMHKRAQRL CCCCEEEHHHHHHHH	3.19	23000965
1319	Ubiquitination	LDGVFMHKRAQRLKF CCEEEHHHHHHHHHH	37.33	23000965
1319 (in isoform 1)	Ubiquitination	-	37.33	21890473
1325	Ubiquitination	HKRAQRLKFLCERND HHHHHHHHHHHHCCC	38.18	23000965
1333	Ubiquitination	FLCERNDKVFFASVR HHHHCCCEEEEEEEE	44.48	-
1338	Phosphorylation	NDKVFFASVRSGGSS CCEEEEEEEECCCCC	16.95	24961811
1351	Phosphorylation	SSQVFFMTLNRNSMM CCEEEEEEECCCCCC	18.74	30108239

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SMURF1	Q9HCE7	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TNIK_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TNIK_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRAF2_HUMAN	TRAF2	physical	10521462
DYST_HUMAN	DST	physical	17043677
SYNE1_HUMAN	SYNE1	physical	17043677
TNKS1_HUMAN	TNKS	physical	17043677
SOS1_HUMAN	SOS1	physical	17043677
SPTB2_HUMAN	SPTBN1	physical	17043677
MACF1_HUMAN	MACF1	physical	17043677
MYOME_HUMAN	PDE4DIP	physical	17043677
GOGA4_HUMAN	GOLGA4	physical	17043677
SRGP3_HUMAN	SRGAP3	physical	17043677
ANK2_HUMAN	ANK2	physical	17043677
TRIM2_HUMAN	TRIM2	physical	17043677
DPYL3_HUMAN	DPYSL3	physical	17043677
SYHC_HUMAN	HARS	physical	17043677
KIBRA_HUMAN	WWC1	physical	17043677
TIAM2_HUMAN	TIAM2	physical	17043677
TBB2A_HUMAN	TUBB2A	physical	17043677
AKAP9_HUMAN	AKAP9	physical	17043677
CLUS_HUMAN	CLU	physical	17043677
DPYL2_HUMAN	DPYSL2	physical	17043677
NFM_HUMAN	NEFM	physical	17043677
CBPC1_HUMAN	AGTPBP1	physical	17043677
CNKR2_HUMAN	CNKSR2	physical	17043677
NCOR2_HUMAN	NCOR2	physical	17043677
DYHC1_HUMAN	DYNC1H1	physical	17043677
ASPP1_HUMAN	PPP1R13B	physical	17043677
SNX6_HUMAN	SNX6	physical	17043677
GSE1_HUMAN	GSE1	physical	17043677
ACTG_HUMAN	ACTG1	physical	17043677
LIS1_HUMAN	PAFAH1B1	physical	17043677
PPM1E_HUMAN	PPM1E	physical	17043677
SMCE1_HUMAN	SMARCE1	physical	17043677
LMP1_EBVB9	LMP1	physical	22904686
TRAF6_HUMAN	TRAF6	physical	22904686
M3K7_HUMAN	MAP3K7	physical	22904686
TAB2_HUMAN	TAB2	physical	22904686
IKKB_HUMAN	IKBKB	physical	22904686

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TNIK_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-319; TYR-321; TYR-323;SER-324; SER-326; SER-335; SER-560; THR-581; SER-640; SER-678;SER-680; SER-688; SER-707; SER-720; SER-764; SER-766; SER-769;SER-830; SER-831; SER-832; SER-833; SER-838; SER-839; SER-951 ANDTYR-982, AND MASS SPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-678; SER-680; SER-726AND SER-755, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-678 AND SER-680, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-324; SER-326; SER-560;SER-640; SER-678; SER-680; SER-688; SER-707; SER-720; SER-769 ANDTHR-1036, AND MASS SPECTROMETRY.	18691976 [Abstract]
"Phosphorylation analysis of primary human T lymphocytes usingsequential IMAC and titanium oxide enrichment."; Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.; J. Proteome Res. 7:5167-5176(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-769, AND MASSSPECTROMETRY.	19367720 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-581; SER-640; THR-677;SER-680; SER-764 AND SER-769, AND MASS SPECTROMETRY.	18088087 [Abstract]
"Proteomics analysis of protein kinases by target class-selectiveprefractionation and tandem mass spectrometry."; Wissing J., Jaensch L., Nimtz M., Dieterich G., Hornberger R.,Keri G., Wehland J., Daub H.; Mol. Cell. Proteomics 6:537-547(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-680; SER-764 ANDSER-769, AND MASS SPECTROMETRY.	17192257 [Abstract]
"Robust phosphoproteomic profiling of tyrosine phosphorylation sitesfrom human T cells using immobilized metal affinity chromatography andtandem mass spectrometry."; Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M.,Peters E.C.; Anal. Chem. 76:2763-2772(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-764 AND SER-769, ANDMASS SPECTROMETRY.	15144186 [Abstract]