CNKR2_HUMAN - dbPTM
CNKR2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CNKR2_HUMAN
UniProt AC Q8WXI2
Protein Name Connector enhancer of kinase suppressor of ras 2
Gene Name CNKSR2
Organism Homo sapiens (Human).
Sequence Length 1034
Subcellular Localization Cytoplasm. Membrane
Peripheral membrane protein.
Protein Description May function as an adapter protein or regulator of Ras signaling pathways..
Protein Sequence MALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYEDPNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSESREEKLGDSLQDLYRALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYLDLFLDICQNTTSNDPLSISSEVDVITSSLAHTHSYIETHV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12PhosphorylationMEPVSKWSPSQVVDW
CCCCCCCCHHHHHHH		20.5724076635
168PhosphorylationIQLCLELTTIVQQDC
HHHHHHHHHHHHCCC		12.7124043423
169PhosphorylationQLCLELTTIVQQDCT
HHHHHHHHHHHCCCE		31.6024043423
176PhosphorylationTIVQQDCTVYETENK
HHHHCCCEEEECCHH		34.1224043423
178PhosphorylationVQQDCTVYETENKIL
HHCCCEEEECCHHHH		10.0524043423
180PhosphorylationQDCTVYETENKILHV
CCCEEEECCHHHHHH		27.4624043423
235PhosphorylationGMYIKSTYDGLHVIT
CCEEEEECCCEEEEE		18.3325954137
242PhosphorylationYDGLHVITGTTENSP
CCCEEEEEECCCCCH		27.6425954137
245PhosphorylationLHVITGTTENSPADR
EEEEEECCCCCHHHH		34.2225954137
248PhosphorylationITGTTENSPADRCKK
EEECCCCCHHHHHCC		18.4221082442
292PhosphorylationDPSGVILTLKKRPQS
CCCCEEEEECCCCHH		25.96-
299PhosphorylationTLKKRPQSMLTSAPA
EECCCCHHHHCCHHH		20.6023403867
302PhosphorylationKRPQSMLTSAPALLK
CCCHHHHCCHHHHHH		17.7523403867
303PhosphorylationRPQSMLTSAPALLKN
CCHHHHCCHHHHHHC		28.4423403867
325PhosphorylationLQPLIPRSPTSSVAT
EECCCCCCCCCCCCC		27.4627732954
325 (in isoform 5)Phosphorylation-27.4624719451
327PhosphorylationPLIPRSPTSSVATPS
CCCCCCCCCCCCCCC		34.5827732954
328PhosphorylationLIPRSPTSSVATPSS
CCCCCCCCCCCCCCC		26.6327732954
329PhosphorylationIPRSPTSSVATPSST
CCCCCCCCCCCCCCC		20.4627732954
332PhosphorylationSPTSSVATPSSTIST
CCCCCCCCCCCCCCC		22.8827732954
334PhosphorylationTSSVATPSSTISTPT
CCCCCCCCCCCCCCC		35.4427732954
335PhosphorylationSSVATPSSTISTPTK
CCCCCCCCCCCCCCC		30.8527732954
336PhosphorylationSVATPSSTISTPTKR
CCCCCCCCCCCCCCC		24.2427732954
338PhosphorylationATPSSTISTPTKRDS
CCCCCCCCCCCCCCC		28.5527732954
339PhosphorylationTPSSTISTPTKRDSS
CCCCCCCCCCCCCCC		31.0025307156
341PhosphorylationSSTISTPTKRDSSAL
CCCCCCCCCCCCCCH		38.5127732954
388PhosphorylationGKPVHKGSESPNSFL
CCCCCCCCCCCCCCC		39.4430266825
388 (in isoform 5)Phosphorylation-39.4424719451
390PhosphorylationPVHKGSESPNSFLDQ
CCCCCCCCCCCCCCH		30.9519664994
390 (in isoform 5)Phosphorylation-30.9524719451
393PhosphorylationKGSESPNSFLDQEYR
CCCCCCCCCCCHHHH		30.4830266825
423PhosphorylationEYEKGRSSSQGRRES
EECCCCCCCCCCCCC		25.8926657352
424PhosphorylationYEKGRSSSQGRREST
ECCCCCCCCCCCCCC		37.5926657352
430 (in isoform 5)Phosphorylation-37.5624719451
431 (in isoform 5)Phosphorylation-18.2028348404
433PhosphorylationGRRESTPTYGKLRPI
CCCCCCCCCCCCCCC		45.02-
433 (in isoform 5)Phosphorylation-45.0227732954
434PhosphorylationRRESTPTYGKLRPIS
CCCCCCCCCCCCCCC		17.29-
434 (in isoform 5)Phosphorylation-17.2927732954
437 (in isoform 5)Phosphorylation-7.3627732954
443 (in isoform 5)Phosphorylation-14.7024719451
452PhosphorylationEYNWVGDYEDPNKMK
EECCCCCCCCCCCCC		19.1225884760
452 (in isoform 5)Phosphorylation-19.1227642862
462PhosphorylationPNKMKRDSRRENSLL
CCCCCCCCHHHHHHH		36.9529449344
467PhosphorylationRDSRRENSLLRYMSN
CCCHHHHHHHHHHHH		24.8324719451
471PhosphorylationRENSLLRYMSNEKIA
HHHHHHHHHHHHHHH		12.5929449344
473PhosphorylationNSLLRYMSNEKIAQE
HHHHHHHHHHHHHHH		32.6627422710
477 (in isoform 5)Phosphorylation-3.7924719451
488PhosphorylationEYMFQRNSKKDTGKK
HHHHHHCCCCCCCCC		43.1829449344
503PhosphorylationSKKKGDKSNSPTHYS
CCCCCCCCCCCCHHH		47.4821406692
505PhosphorylationKKGDKSNSPTHYSLL
CCCCCCCCCCHHHHC		37.9621406692
507PhosphorylationGDKSNSPTHYSLLPS
CCCCCCCCHHHHCHH		33.0124114839
509PhosphorylationKSNSPTHYSLLPSLQ
CCCCCCHHHHCHHHC		11.9521406692
510PhosphorylationSNSPTHYSLLPSLQM
CCCCCHHHHCHHHCH		18.8024114839
514PhosphorylationTHYSLLPSLQMDALR
CHHHHCHHHCHHHHH		31.0723836654
527PhosphorylationLRQDIMGTPVPETTL
HHCHHCCCCCCHHHH		12.0627732954
532PhosphorylationMGTPVPETTLYHTFQ
CCCCCCHHHHHHHHH		18.9427732954
533PhosphorylationGTPVPETTLYHTFQQ
CCCCCHHHHHHHHHH		24.5327732954
534 (in isoform 5)Phosphorylation-3.7324719451
535PhosphorylationPVPETTLYHTFQQSS
CCCHHHHHHHHHHHH		9.2027732954
537PhosphorylationPETTLYHTFQQSSLQ
CHHHHHHHHHHHHHH		15.0227732954
541PhosphorylationLYHTFQQSSLQHKSK
HHHHHHHHHHHHHCC		23.4127732954
542PhosphorylationYHTFQQSSLQHKSKK
HHHHHHHHHHHHCCC		27.9227732954
564PhosphorylationGKSKRRISCKDLGRG
CCCCCCCCCCCCCCC		17.1924719451
585PhosphorylationWKKKDAKSYFSQKWK
EECCCHHHHHCHHHH		32.8829083192
586PhosphorylationKKKDAKSYFSQKWKK
ECCCHHHHHCHHHHE		13.4229083192
588PhosphorylationKDAKSYFSQKWKKYW
CCHHHHHCHHHHEEE		23.7129083192
635PhosphorylationASECRKKYAFKACHP
HHHHHHHHHHHHHCH		21.9529457462
683PhosphorylationRIKQEQDYWSESDKE
HHHHHHHHCCHHHHC		15.5530177828
685PhosphorylationKQEQDYWSESDKEEA
HHHHHHCCHHHHCCC		22.4629523821
687PhosphorylationEQDYWSESDKEEADT
HHHHCCHHHHCCCCC		48.7629523821
694PhosphorylationSDKEEADTPSTPKQD
HHHCCCCCCCCCCCC		26.62-
702PhosphorylationPSTPKQDSPPPPYDT
CCCCCCCCCCCCCCC		36.4930266825
707PhosphorylationQDSPPPPYDTYPRPP
CCCCCCCCCCCCCCC		27.0530266825
709PhosphorylationSPPPPYDTYPRPPSM
CCCCCCCCCCCCCCC		29.5830266825
710PhosphorylationPPPPYDTYPRPPSMS
CCCCCCCCCCCCCCC		8.3730266825
717PhosphorylationYPRPPSMSCASPYVE
CCCCCCCCCCCCHHH		15.7424275569
722PhosphorylationSMSCASPYVEAKHSR
CCCCCCCHHHHHHHH		14.3924275569
728PhosphorylationPYVEAKHSRLSSTET
CHHHHHHHHCCCCCC		33.9222210691
731PhosphorylationEAKHSRLSSTETSQS
HHHHHHCCCCCCCCC		33.8227732954
732PhosphorylationAKHSRLSSTETSQSQ
HHHHHCCCCCCCCCC		34.5528655764
733PhosphorylationKHSRLSSTETSQSQS
HHHHCCCCCCCCCCC		39.6527732954
735PhosphorylationSRLSSTETSQSQSSH
HHCCCCCCCCCCCHH		31.9627732954
736PhosphorylationRLSSTETSQSQSSHE
HCCCCCCCCCCCHHH		22.9227732954
738PhosphorylationSSTETSQSQSSHEEF
CCCCCCCCCCHHHHH		31.6227732954
740PhosphorylationTETSQSQSSHEEFRQ
CCCCCCCCHHHHHHH		38.6222210691
741PhosphorylationETSQSQSSHEEFRQE
CCCCCCCHHHHHHHH		27.5522210691
750PhosphorylationEEFRQEVTGSSAVSP
HHHHHHHHCCCCCCC		30.5129255136
752PhosphorylationFRQEVTGSSAVSPIR
HHHHHHCCCCCCCHH		13.0327732954
753PhosphorylationRQEVTGSSAVSPIRK
HHHHHCCCCCCCHHH		33.7527732954
756PhosphorylationVTGSSAVSPIRKTAS
HHCCCCCCCHHHCHH		17.8329255136
767PhosphorylationKTASQRRSWQDLIET
HCHHHCCCHHHHHHC		31.1429523821
778 (in isoform 5)Phosphorylation-30.0524719451
808PhosphorylationSPEHRRQSTLPTQKC
CHHHHHHCCCCCCCC		30.0524719451
816 (in isoform 5)Phosphorylation-33.2924719451
821PhosphorylationKCHLQDHYGPYPLAE
CCCCCCCCCCCCCCH		28.2522817900
846PhosphorylationGGKPRSFTLPRDSGF
CCCCCCEECCCCCCC		36.7824719451
878 (in isoform 5)Phosphorylation-75.7224719451
908PhosphorylationREEKLGDSLQDLYRA
HHHHHHHHHHHHHHH		26.5719664994
913PhosphorylationGDSLQDLYRALEQAS
HHHHHHHHHHHHHCC		11.3521406692
938PhosphorylationTKMEYKLSFIKRCND
CCCCHHHHHHHHCCC		22.3024719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CNKR2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CNKR2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CNKR2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MOB3B_HUMANMOB3Bphysical
17353931
RAF1_HUMANRAF1physical
14597674
RALA_HUMANRALAphysical
14597674
RLF_HUMANRLFphysical
14597674
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CNKR2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-908, AND MASSSPECTROMETRY.

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