TIAM2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TIAM2_HUMAN
• UniProt AC: Q8IVF5
• Protein Name: T-lymphoma invasion and metastasis-inducing protein 2
• Gene Name: TIAM2
• Organism: Homo sapiens (Human).
• Sequence Length: 1701
• Subcellular Localization: Cytoplasm. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, growth cone. Localizes to the plasma membrane in neurites..
• Protein Description: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity). Activates specifically RAC1, but not CDC42 and RHOA..
• Protein Sequence: MGNSDSQYTLQGSKNHSNTITGAKQIPCSLKIRGIHAKEEKSLHGWGHGSNGAGYKSRSLARSCLSHFKSNQPYASRLGGPTCKVSRGVAYSTHRTNAPGKDFQGISAAFSTENGFHSVGHELADNHITSRDCNGHLLNCYGRNESIASTPPGEDRKSPRVLIKTLGKLDGCLRVEFHNGGNPSKVPAEDCSEPVQLLRYSPTLASETSPVPEARRGSSADSLPSHRPSPTDSRLRSSKGSSLSSESSWYDSPWGNAGELSEAEGSFLAPGMPDPSLHASFPPGDAKKPFNQSSSLSSLRELYKDANLGSLSPSGIRLSDEYMGTHASLSNRVSFASDIDVPSRVAHGDPIQYSSFTLPCRKPKAFVEDTAKKDSLKARMRRISDWTGSLSRKKRKLQEPRSKEGSDYFDSRSDGLNTDVQGSSQASAFLWSGGSTQILSQRSESTHAIGSDPLRQNIYENFMRELEMSRTNTENIETSTETAESSSESLSSLEQLDLLFEKEQGVVRKAGWLFFKPLVTVQKERKLELVARRKWKQYWVTLKGCTLLFYETYGKNSMDQSSAPRCALFAEDSIVQSVPEHPKKENVFCLSNSFGDVYLFQATSQTDLENWVTAVHSACASLFAKKHGKEDTLRLLKNQTKNLLQKIDMDSKMKKMAELQLSVVSDPKNRKAIENQIQQWEQNLEKFHMDLFRMRCYLASLQGGELPNPKSLLAAASRPSKLALGRLGILSVSSFHALVCSRDDSALRKRTLSLTQRGRNKKGIFSSLKGLDTLARKGKEKRPSITQVDELLHIYGSTVDGVPRDNAWEIQTYVHFQDNHGVTVGIKPEHRVEDILTLACKMRQLEPSHYGLQLRKLVDDNVEYCIPAPYEYMQQQVYDEIEVFPLNVYDVQLTKTGSVCDFGFAVTAQVDERQHLSRIFISDVLPDGLAYGEGLRKGNEIMTLNGEAVSDLDLKQMEALFSEKSVGLTLIARPPDTKATLCTSWSDSDLFSRDQKSLLPPPNQSQLLEEFLDNFKKNTANDFSNVPDITTGLKRSQTDGTLDQVSHREKMEQTFRSAEQITALCRSFNDSQANGMEGPRENQDPPPRSLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWLNPFLSLGKARKDLELTVFVFKRAVILVYKENCKLKKKLPSNSRPAHNSTDLDPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIEGRPETIFQLCCSDSESKTNIVKVIRSILRENFRRHIKCELPLEKTCKDRLVPLKNRVPVSAKLASSRSLKVLKNSSSNEWTGETGKGTLLDSDEGSLSSGTQSSGCPTAEGRQDSKSTSPGKYPHPGLADFADNLIKESDILSDEDDDHRQTVKQGSPTKDIEIQFQRLRISEDPDVHPEAEQQPGPESGEGQKGGEQPKLVRGHFCPIKRKANSTKRDRGTLLKAQIRHQSLDSQSENATIDLNSVLEREFSVQSLTSVVSEECFYETESHGKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGNSDSQYT ------CCCCCCCEE	54.36	-
17	Phosphorylation	LQGSKNHSNTITGAK ECCCCCCCCCCCCCE	45.09	-
21	Phosphorylation	KNHSNTITGAKQIPC CCCCCCCCCCEECCC	29.11	-
59	Phosphorylation	GAGYKSRSLARSCLS CCCHHHHHHHHHHHH	33.21	27174698
69	Methylation	RSCLSHFKSNQPYAS HHHHHHHHCCCCCHH	42.97	115979935
91	Phosphorylation	KVSRGVAYSTHRTNA EECCCEEECCCCCCC	16.22	30257219
146	Phosphorylation	NCYGRNESIASTPPG ECCCCCCCCCCCCCC	27.31	27251275
149	Phosphorylation	GRNESIASTPPGEDR CCCCCCCCCCCCCCC	39.51	27732954
150	Phosphorylation	RNESIASTPPGEDRK CCCCCCCCCCCCCCC	25.20	27732954
158	Phosphorylation	PPGEDRKSPRVLIKT CCCCCCCCCCHHHHH	20.87	27732954
200	Phosphorylation	EPVQLLRYSPTLASE CCCHHHHCCCCCCCC	20.97	26657352
201	Phosphorylation	PVQLLRYSPTLASET CCHHHHCCCCCCCCC	12.65	29255136
203	Phosphorylation	QLLRYSPTLASETSP HHHHCCCCCCCCCCC	29.08	29255136
206	Phosphorylation	RYSPTLASETSPVPE HCCCCCCCCCCCCCH	44.51	27732954
208	Phosphorylation	SPTLASETSPVPEAR CCCCCCCCCCCCHHH	35.52	27732954
209	Phosphorylation	PTLASETSPVPEARR CCCCCCCCCCCHHHC	21.61	22777824
218	Phosphorylation	VPEARRGSSADSLPS CCHHHCCCCCCCCCC	22.12	27251275
219	Phosphorylation	PEARRGSSADSLPSH CHHHCCCCCCCCCCC	38.63	28348404
222	Phosphorylation	RRGSSADSLPSHRPS HCCCCCCCCCCCCCC	41.73	27251275
225	Phosphorylation	SSADSLPSHRPSPTD CCCCCCCCCCCCCCC	37.10	27251275
229	Phosphorylation	SLPSHRPSPTDSRLR CCCCCCCCCCCHHCC	40.15	24501219
231	Phosphorylation	PSHRPSPTDSRLRSS CCCCCCCCCHHCCCC	51.44	27251275
233	Phosphorylation	HRPSPTDSRLRSSKG CCCCCCCHHCCCCCC	35.37	27251275
293	Phosphorylation	AKKPFNQSSSLSSLR CCCCCCCCCCHHHHH	24.01	25072903
294	Phosphorylation	KKPFNQSSSLSSLRE CCCCCCCCCHHHHHH	26.07	25072903
295	Phosphorylation	KPFNQSSSLSSLREL CCCCCCCCHHHHHHH	37.20	22167270
297	Phosphorylation	FNQSSSLSSLRELYK CCCCCCHHHHHHHHH	29.31	22167270
298	Phosphorylation	NQSSSLSSLRELYKD CCCCCHHHHHHHHHH	36.42	22167270
310	Phosphorylation	YKDANLGSLSPSGIR HHHCCCCCCCCCCCC	28.92	29255136
312	Phosphorylation	DANLGSLSPSGIRLS HCCCCCCCCCCCCCC	20.79	29255136
314	Phosphorylation	NLGSLSPSGIRLSDE CCCCCCCCCCCCCCC	43.40	29255136
322	Phosphorylation	GIRLSDEYMGTHASL CCCCCCCCCCCCCCC	13.06	-
325	Phosphorylation	LSDEYMGTHASLSNR CCCCCCCCCCCCCCC	9.57	-
334	Phosphorylation	ASLSNRVSFASDIDV CCCCCCCCCCCCCCC	16.32	30266825
337	Phosphorylation	SNRVSFASDIDVPSR CCCCCCCCCCCCCCC	32.84	30266825
375	Phosphorylation	EDTAKKDSLKARMRR CCCCCHHHHHHHHHH	40.42	24719451
387	Phosphorylation	MRRISDWTGSLSRKK HHHHHHHHCCHHHHH	23.14	27732954
389	Phosphorylation	RISDWTGSLSRKKRK HHHHHHCCHHHHHHH	18.79	25850435
391	Phosphorylation	SDWTGSLSRKKRKLQ HHHHCCHHHHHHHCC	43.69	25850435
440	Phosphorylation	GGSTQILSQRSESTH CCCHHHEECCCCCCC	25.77	24719451
443	Phosphorylation	TQILSQRSESTHAIG HHHEECCCCCCCCCC	28.41	29255136
445	Phosphorylation	ILSQRSESTHAIGSD HEECCCCCCCCCCCC	27.09	29255136
446	Phosphorylation	LSQRSESTHAIGSDP EECCCCCCCCCCCCH	15.98	29255136
459	Phosphorylation	DPLRQNIYENFMREL CHHHHHHHHHHHHHH	16.63	29978859
662	Phosphorylation	KMAELQLSVVSDPKN HHHHHHHHCCCCHHH	13.91	26657352
697	Phosphorylation	DLFRMRCYLASLQGG HHHHHHHHHHHHCCC	8.57	29978859
700	Phosphorylation	RMRCYLASLQGGELP HHHHHHHHHCCCCCC	20.73	19664994
711	Phosphorylation	GELPNPKSLLAAASR CCCCCHHHHHHHHCC	29.85	29978859
717	Phosphorylation	KSLLAAASRPSKLAL HHHHHHHCCCHHHHC	39.74	24719451
766	Phosphorylation	RNKKGIFSSLKGLDT CCCCCHHHHHHHHHH	32.61	27251275
767	Phosphorylation	NKKGIFSSLKGLDTL CCCCHHHHHHHHHHH	24.29	24719451
784	Phosphorylation	KGKEKRPSITQVDEL CCCCCCCCCHHHHHH	42.15	27251275
786	Phosphorylation	KEKRPSITQVDELLH CCCCCCCHHHHHHHH	27.20	29802988
837	Phosphorylation	HRVEDILTLACKMRQ HCHHHHHHHHHHHHC	16.79	25159151
848	Phosphorylation	KMRQLEPSHYGLQLR HHHCCCCCHHHCHHH	21.70	24719451
850	Phosphorylation	RQLEPSHYGLQLRKL HCCCCCHHHCHHHHH	24.70	24719451
943	Phosphorylation	RKGNEIMTLNGEAVS CCCCEEEEECCCCCC	23.80	22210691
950	Phosphorylation	TLNGEAVSDLDLKQM EECCCCCCCCCHHHH	39.23	22210691
980	Phosphorylation	RPPDTKATLCTSWSD CCCCCCCEEECCCCC	24.75	26699800
983	Phosphorylation	DTKATLCTSWSDSDL CCCCEEECCCCCHHH	36.02	26699800
984	Phosphorylation	TKATLCTSWSDSDLF CCCEEECCCCCHHHC	24.48	26699800
986	Phosphorylation	ATLCTSWSDSDLFSR CEEECCCCCHHHCCC	27.31	30266825
988	Phosphorylation	LCTSWSDSDLFSRDQ EECCCCCHHHCCCCH	30.60	26699800
992	Phosphorylation	WSDSDLFSRDQKSLL CCCHHHCCCCHHHCC	42.09	26699800
1036	Phosphorylation	ITTGLKRSQTDGTLD CCCCCCHHCCCCCHH	35.53	30266825
1038	Phosphorylation	TGLKRSQTDGTLDQV CCCCHHCCCCCHHHH	37.33	30266825
1041	Phosphorylation	KRSQTDGTLDQVSHR CHHCCCCCHHHHHHH	29.94	30266825
1057	Phosphorylation	KMEQTFRSAEQITAL HHHHHHHCHHHHHHH	31.78	26657352
1095	Phosphorylation	RSLARHLSDADRLRK HHHHHHHCHHHHHHH	25.32	23403867
1142	Phosphorylation	LTQDEMESLFGSLPE CCHHHHHHHHCCHHH	27.91	22468782
1146	Phosphorylation	EMESLFGSLPEMLEF HHHHHHCCHHHHHHH	33.16	22468782
1254	Ubiquitination	KPVQRVLKYPLLLKE HHHHHHHHHHHHHHH	41.80	-
1444	Phosphorylation	CSDSESKTNIVKVIR CCCCCCCHHHHHHHH	39.18	-
1448	Ubiquitination	ESKTNIVKVIRSILR CCCHHHHHHHHHHHH	28.31	-
1480	Methylation	KDRLVPLKNRVPVSA CCCEEECCCCCCCCH	36.32	116253137
1501	Phosphorylation	SLKVLKNSSSNEWTG CCEEEECCCCCCCCC	33.29	28961369
1502	Phosphorylation	LKVLKNSSSNEWTGE CEEEECCCCCCCCCC	46.72	28961369
1503	Phosphorylation	KVLKNSSSNEWTGET EEEECCCCCCCCCCC	38.29	28961369
1507	Phosphorylation	NSSSNEWTGETGKGT CCCCCCCCCCCCCCE	20.97	28961369
1510	Phosphorylation	SNEWTGETGKGTLLD CCCCCCCCCCCEEEC	45.60	28961369
1514	Phosphorylation	TGETGKGTLLDSDEG CCCCCCCEEECCCCC	27.86	28961369
1518	Phosphorylation	GKGTLLDSDEGSLSS CCCEEECCCCCCCCC	37.22	28961369
1522	Phosphorylation	LLDSDEGSLSSGTQS EECCCCCCCCCCCCC	24.03	28961369
1524	Phosphorylation	DSDEGSLSSGTQSSG CCCCCCCCCCCCCCC	28.55	28961369
1525	Phosphorylation	SDEGSLSSGTQSSGC CCCCCCCCCCCCCCC	51.67	28961369
1527	Phosphorylation	EGSLSSGTQSSGCPT CCCCCCCCCCCCCCC	27.50	28961369
1530	Phosphorylation	LSSGTQSSGCPTAEG CCCCCCCCCCCCCCC	34.30	28961369
1534	Phosphorylation	TQSSGCPTAEGRQDS CCCCCCCCCCCCCCC	41.22	28961369
1543	Phosphorylation	EGRQDSKSTSPGKYP CCCCCCCCCCCCCCC	37.76	30108239
1544	Phosphorylation	GRQDSKSTSPGKYPH CCCCCCCCCCCCCCC	42.55	20886841
1545	Phosphorylation	RQDSKSTSPGKYPHP CCCCCCCCCCCCCCC	38.45	30108239
1549	Phosphorylation	KSTSPGKYPHPGLAD CCCCCCCCCCCCHHH	16.82	24117733
1565	Phosphorylation	ADNLIKESDILSDED HHHHHHHHHCCCCCC	25.58	29514088
1569	Phosphorylation	IKESDILSDEDDDHR HHHHHCCCCCCCHHH	39.01	29255136
1578	Phosphorylation	EDDDHRQTVKQGSPT CCCHHHHHHHCCCCC	29.63	29514088
1583	Phosphorylation	RQTVKQGSPTKDIEI HHHHHCCCCCCCEEE	27.23	26657352
1585	Phosphorylation	TVKQGSPTKDIEIQF HHHCCCCCCCEEEEE	42.94	25332170
1642	Phosphorylation	IKRKANSTKRDRGTL CCCCCCCCCCCCCHH	29.88	16674116
1648	Phosphorylation	STKRDRGTLLKAQIR CCCCCCCHHHHHHHH	29.79	-
1658	Phosphorylation	KAQIRHQSLDSQSEN HHHHHHHCCCCCCCC	28.19	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TIAM2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1648	T	Phosphorylation	Phosphorylated on Thr-1648 by Rho-kinase.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TIAM2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TIAM2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.