LMP1_EBVB9 - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LMP1_EBVB9
• UniProt AC: P03230
• Protein Name: Latent membrane protein 1
• Gene Name: LMP1
• Organism: Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4).
• Sequence Length: 386
• Subcellular Localization: Host cell membrane ; Multi-pass membrane protein .
• Protein Description: Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family. LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells. Interacts with host UBE2I and subsequently affects the sumoylation state of several cellular proteins. For example, induces the sumoylation of host IRF7 thereby limiting its transcriptional activity and modulating the activation of innate immune responses..
• Protein Sequence: MEHDLERGPPGPRRPPRGPPLSSSLGLALLLLLLALLFWLYIVMSDWTGGALLVLYSFALMLIIIILIIFIFRRDLLCPLGALCILLLMITLLLIALWNLHGQALFLGIVLFIFGCLLVLGIWIYLLEMLWRLGATIWQLLAFFLAFFLDLILLIIALYLQQNWWTLLVDLLWLLLFLAILIWMYYHGQRHSDEHHHDDSLPHPQQATDDSGHESDSNSNEGRHHLLVSGAGDGPPLCSQNLGAPGGGPDNGPQDPDNTDDNGPQDPDNTDDNGPHDPLPQDPDNTDDNGPQDPDNTDDNGPHDPLPHSPSDSAGNDGGPPQLTEEVENKGGDQGPPLMTDGGGGHSHDSGHGGGDPHLPTLLLGSSGSGGDDDDPHGPVQLSYYD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MEHDLERGP ------CCCCCCCCC	46.22	-
78	S-palmitoylation	IFRRDLLCPLGALCI HHHHHCCCHHHHHHH	3.21	11296297
330	Ubiquitination	LTEEVENKGGDQGPP HHHHHHHCCCCCCCC	51.25	PubMed

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
211	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
215	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LMP1_EBVB9 !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LMP1_EBVB9 !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TNAP3_HUMAN	TNFAIP3	physical	10544141
TRAF1_HUMAN	TRAF1	physical	10544141
TRAF2_HUMAN	TRAF2	physical	10544141
TRADD_HUMAN	TRADD	physical	10544141
ZMY11_HUMAN	ZMYND11	physical	20138174
TRAF3_HUMAN	TRAF3	physical	9151858
TRAF1_HUMAN	TRAF1	physical	9151858
TRAF2_HUMAN	TRAF2	physical	9151858
TRAF3_HUMAN	TRAF3	physical	22904686
TNIK_HUMAN	TNIK	physical	22904686
M3K7_HUMAN	MAP3K7	physical	22904686
TAB2_HUMAN	TAB2	physical	22904686

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.