dbPTM

MTR1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MTR1A_HUMAN
UniProt AC	P48039
Protein Name	Melatonin receptor type 1A
Gene Name	MTNR1A
Organism	Homo sapiens (Human).
Sequence Length	350
Subcellular Localization	Cell membrane Multi-pass membrane protein.
Protein Description	High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity..
Protein Sequence	MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	N-linked_Glycosylation	----MQGNGSALPNA ----CCCCCCCCCCC	25.10	UniProtKB CARBOHYD
10	N-linked_Glycosylation	GNGSALPNASQPVLR CCCCCCCCCCCCCCC	53.74	UniProtKB CARBOHYD
51	Phosphorylation	GNLLVILSVYRNKKL HHHHHHHHHHCCCCC	13.13	24719451
127	S-nitrosocysteine	GIAINRYCYICHSLK HHHHHHCHHHHHHCC	1.34	-
127	S-nitrosylation	GIAINRYCYICHSLK HHHHHHCHHHHHHCC	1.34	22178444
130	S-nitrosocysteine	INRYCYICHSLKYDK HHHCHHHHHHCCCCH	0.47	-
130	S-nitrosylation	INRYCYICHSLKYDK HHHCHHHHHHCCCCH	0.47	22178444

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MTR1A_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MTR1A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MTR1A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GNAI3_HUMAN	GNAI3	physical	10598579
GNAI2_HUMAN	GNAI2	physical	10598579
GNA11_HUMAN	GNA11	physical	10598579
GNAI1_HUMAN	GNAI1	physical	17215244
GBB1_HUMAN	GNB1	physical	17215244
GBB4_HUMAN	GNB4	physical	17215244
GNAI3_HUMAN	GNAI3	physical	17215244
GNAI2_HUMAN	GNAI2	physical	17215244
CN37_HUMAN	CNP	physical	17215244
RAP1A_HUMAN	RAP1A	physical	17215244
RAC1_HUMAN	RAC1	physical	17215244
EF1G_HUMAN	EEF1G	physical	17215244
IRS4_HUMAN	IRS4	physical	17215244
FLNA_HUMAN	FLNA	physical	17215244
CALX_HUMAN	CANX	physical	17215244
GRP78_HUMAN	HSPA5	physical	17215244
CALR_HUMAN	CALR	physical	17215244
PDIA6_HUMAN	PDIA6	physical	17215244
VAPB_HUMAN	VAPB	physical	17215244
RAB10_HUMAN	RAB10	physical	17215244
PGRC1_HUMAN	PGRMC1	physical	17215244
LRC59_HUMAN	LRRC59	physical	17215244
TMM33_HUMAN	TMEM33	physical	17215244
ROA0_HUMAN	HNRNPA0	physical	17215244
SNP25_MOUSE	Snap25	physical	26514267
SYN1_MOUSE	Syn1	physical	26514267
SYN2_MOUSE	Syn2	physical	26514267
STXB1_MOUSE	Stxbp1	physical	26514267
CAC1B_MOUSE	Cacna1b	physical	26514267
CAC1B_HUMAN	CACNA1B	physical	26514267
S4A4_MOUSE	Slc4a4	physical	26514267
1433B_MOUSE	Ywhab	physical	26514267
KAD1_MOUSE	Ak1	physical	26514267
CSN4_MOUSE	Cops4	physical	26514267
KPCZ_MOUSE	Prkcz	physical	26514267
DUS3_MOUSE	Dusp3	physical	26514267
PP2AB_MOUSE	Ppp2cb	physical	26514267
RPH3L_MOUSE	Rph3al	physical	26514267
RGS20_MOUSE	Rgs20	physical	26514267
UBP5_MOUSE	Usp5	physical	26514267
OTUB1_MOUSE	Otub1	physical	26514267
ACTY_MOUSE	Actr1b	physical	26514267
CLAP1_MOUSE	Clasp1	physical	26514267
COF1_MOUSE	Cfl1	physical	26514267
COF2_MOUSE	Cfl2	physical	26514267
CLIP2_MOUSE	Clip2	physical	26514267
DEST_MOUSE	Dstn	physical	26514267
DYN1_MOUSE	Dnm1	physical	26514267
GFAP_MOUSE	Gfap	physical	26514267
KINH_MOUSE	Kif5b	physical	26514267
GMFB_MOUSE	Gmfb	physical	26514267
MYH7_MOUSE	Myh7	physical	26514267
TCPE_MOUSE	Cct5	physical	26514267
DJB11_MOUSE	Dnajb11	physical	26514267
DPYL1_MOUSE	Crmp1	physical	26514267
PYGB_MOUSE	Pygb	physical	26514267
DPYL2_MOUSE	Dpysl2	physical	26514267
SNP47_MOUSE	Snap47	physical	26514267
MFR1L_MOUSE	Mtfr1l	physical	26514267
PPAC_MOUSE	Acp1	physical	26514267
ABCB5_MOUSE	Abcb5	physical	26514267
TBA1C_MOUSE	Tuba1c	physical	26514267
TBB3_MOUSE	Tubb3	physical	26514267
TBA1B_MOUSE	Tuba1b	physical	26514267
IMDH2_MOUSE	Impdh2	physical	26514267
TBA1A_MOUSE	Tuba1a	physical	26514267
TBA4A_MOUSE	Tuba4a	physical	26514267
TBB4A_MOUSE	Tubb4a	physical	26514267
UBA1_MOUSE	Uba1	physical	26514267
T4S1_MOUSE	Tm4sf1	physical	26514267
GP151_MOUSE	Gpr151	physical	26514267
DLL1_MOUSE	Dll1	physical	26514267
KPCL_MOUSE	Prkch	physical	26514267
GRP4_MOUSE	Rasgrp4	physical	26514267
MARK2_MOUSE	Mark2	physical	26514267
UCHL5_MOUSE	Uchl5	physical	26514267
UCHL1_MOUSE	Uchl1	physical	26514267
MYO1B_MOUSE	Myo1b	physical	26514267
DMD_MOUSE	Dmd	physical	26514267
GRP75_MOUSE	Hspa9	physical	26514267
HSPB1_MOUSE	Hspb1	physical	26514267
HSP7C_MOUSE	Hspa8	physical	26514267
QOR_MOUSE	Cryz	physical	26514267
CCS_MOUSE	Ccs	physical	26514267
GBB4_HUMAN	GNB4	physical	26514267
GNAI3_HUMAN	GNAI3	physical	26514267
GNAI1_HUMAN	GNAI1	physical	26514267
GNAI2_HUMAN	GNAI2	physical	26514267
RAC1_HUMAN	RAC1	physical	26514267
EF1G_HUMAN	EEF1G	physical	26514267
IRS4_HUMAN	IRS4	physical	26514267
FLNA_HUMAN	FLNA	physical	26514267
CALX_HUMAN	CANX	physical	26514267
CALR_HUMAN	CALR	physical	26514267
PDIA6_HUMAN	PDIA6	physical	26514267
VAPB_HUMAN	VAPB	physical	26514267
RAB10_HUMAN	RAB10	physical	26514267
PGRC1_HUMAN	PGRMC1	physical	26514267
LRC59_HUMAN	LRRC59	physical	26514267
TMM33_HUMAN	TMEM33	physical	26514267
ROA0_HUMAN	HNRNPA0	physical	26514267
RACK1_HUMAN	GNB2L1	physical	26514267
RNF41_HUMAN	RNF41	physical	26514267
PCDBA_HUMAN	PCDHB10	physical	26514267
PTPRD_HUMAN	PTPRD	physical	26514267
COMT_HUMAN	COMT	physical	26514267
TM230_HUMAN	TMEM230	physical	26514267
SC6A3_HUMAN	SLC6A3	physical	26514267
PEX14_HUMAN	PEX14	physical	26514267
MAMD1_HUMAN	MAMLD1	physical	26514267
CC167_HUMAN	CCDC167	physical	26514267
LAP4A_HUMAN	LAPTM4A	physical	26514267
RL3_HUMAN	RPL3	physical	26514267
HMGN2_HUMAN	HMGN2	physical	26514267
TM9S1_HUMAN	TM9SF1	physical	26514267
SURF4_HUMAN	SURF4	physical	26514267
EMC7_HUMAN	EMC7	physical	26514267
CJ090_HUMAN	C10orf90	physical	26514267
GTR3_HUMAN	SLC2A3	physical	26514267
PYRG2_HUMAN	CTPS2	physical	26514267
G3P_HUMAN	GAPDH	physical	26514267
ZDH16_HUMAN	ZDHHC16	physical	26514267
EMD_HUMAN	EMD	physical	26514267
CJ035_HUMAN	C10orf35	physical	26514267
1433B_HUMAN	YWHAB	physical	26514267
LRP3_HUMAN	LRP3	physical	26514267
TBB5_HUMAN	TUBB	physical	26514267
TMX2_HUMAN	TMX2	physical	26514267
TV23B_HUMAN	TVP23B	physical	26514267
TM14A_HUMAN	TMEM14A	physical	26514267
CAND1_HUMAN	CAND1	physical	26514267
FSTL1_HUMAN	FSTL1	physical	26514267
CRCM_HUMAN	MCC	physical	26514267
MYO9A_HUMAN	MYO9A	physical	26514267
ADRO_HUMAN	FDXR	physical	26514267
HMOX2_HUMAN	HMOX2	physical	26514267
H2A1C_HUMAN	HIST1H2AC	physical	26514267
SOX11_HUMAN	SOX11	physical	26514267
AT5G3_HUMAN	ATP5G3	physical	26514267
CO9A2_HUMAN	COL9A2	physical	26514267
PRLD1_HUMAN	PRELID1	physical	26514267
C27C1_HUMAN	CYP27C1	physical	26514267
LPP_HUMAN	LPP	physical	26514267
NP1L5_HUMAN	NAP1L5	physical	26514267
NSMF_RAT	Nsmf	physical	26514267
ZNT1_HUMAN	SLC30A1	physical	26514267
ACTB_HUMAN	ACTB	physical	26514267
ASCL1_HUMAN	ASCL1	physical	26514267
PUR9_HUMAN	ATIC	physical	26514267
CN166_HUMAN	C14orf166	physical	26514267
COG1_HUMAN	COG1	physical	26514267
DDHD2_HUMAN	DDHD2	physical	26514267
F8I2_HUMAN	F8A1	physical	26514267
GFPT2_HUMAN	GFPT2	physical	26514267
ZEP2_HUMAN	HIVEP2	physical	26514267
LIPS_HUMAN	LIPE	physical	26514267
MMP2_HUMAN	MMP2	physical	26514267
PAXI1_HUMAN	PAXIP1	physical	26514267
P2R3C_HUMAN	PPP2R3C	physical	26514267
RBM39_HUMAN	RBM39	physical	26514267
RGS12_HUMAN	RGS12	physical	26514267
RING2_HUMAN	RNF2	physical	26514267
EXOC1_HUMAN	EXOC1	physical	26514267
GEMI2_HUMAN	GEMIN2	physical	26514267
SLIT1_HUMAN	SLIT1	physical	26514267
SNAPN_HUMAN	SNAPIN	physical	26514267
SORCN_HUMAN	SRI	physical	26514267
STXB1_HUMAN	STXBP1	physical	26514267
UBA1_HUMAN	UBA1	physical	26514267
UBQL1_HUMAN	UBQLN1	physical	26514267
UBP28_HUMAN	USP28	physical	26514267
ANR12_HUMAN	ANKRD12	physical	26514267
BAZ1A_HUMAN	BAZ1A	physical	26514267
BAZ1B_HUMAN	BAZ1B	physical	26514267
CD99_HUMAN	CD99	physical	26514267
CHD4_HUMAN	CHD4	physical	26514267
CTRO_HUMAN	CIT	physical	26514267
COX11_HUMAN	COX11	physical	26514267
CUL7_HUMAN	CUL7	physical	26514267
EPS15_HUMAN	EPS15	physical	26514267
MIP18_HUMAN	FAM96B	physical	26514267
FINC_HUMAN	FN1	physical	26514267
GBA2_HUMAN	GBA2	physical	26514267
HDA10_HUMAN	HDAC10	physical	26514267
IPO9_HUMAN	IPO9	physical	26514267
WASC4_HUMAN	KIAA1033	physical	26514267
CMIP_HUMAN	CMIP	physical	26514267
KLH20_HUMAN	KLHL20	physical	26514267
KLHL5_HUMAN	KLHL5	physical	26514267
IMB1_HUMAN	KPNB1	physical	26514267
MESD_HUMAN	MESDC2	physical	26514267
MMS19_HUMAN	MMS19	physical	26514267
NP1L4_HUMAN	NAP1L4	physical	26514267
NASP_HUMAN	NASP	physical	26514267
PSMD2_HUMAN	PSMD2	physical	26514267
PSME4_HUMAN	PSME4	physical	26514267
SUCB1_HUMAN	SUCLA2	physical	26514267
TLN1_HUMAN	TLN1	physical	26514267
TPP2_HUMAN	TPP2	physical	26514267
UBR4_HUMAN	UBR4	physical	26514267
UBP32_HUMAN	USP32	physical	26514267
WAPL_HUMAN	WAPAL	physical	26514267
ZC11A_HUMAN	ZC3H11A	physical	26514267
ZN460_HUMAN	ZNF460	physical	26514267
ENOG_HUMAN	ENO2	physical	26514267
NP1L1_HUMAN	NAP1L1	physical	26514267
BAG6_HUMAN	BAG6	physical	26514267
CUL3_HUMAN	CUL3	physical	26514267
ECE1_HUMAN	ECE1	physical	26514267
P66B_HUMAN	GATAD2B	physical	26514267
MPDZ_HUMAN	MPDZ	physical	26514267
PTN13_HUMAN	PTPN13	physical	26514267
SVEP1_HUMAN	SVEP1	physical	26514267
TRIPC_HUMAN	TRIP12	physical	26514267
SYVC_HUMAN	VARS	physical	26514267
1433Z_HUMAN	YWHAZ	physical	26514267
CTNA1_HUMAN	CTNNA1	physical	26514267
CLAP1_HUMAN	CLASP1	physical	26514267
ITPR3_HUMAN	ITPR3	physical	26514267
PTX3_HUMAN	PTX3	physical	26514267
UBP2L_HUMAN	UBAP2L	physical	26514267
UBP34_HUMAN	USP34	physical	26514267
ABHEB_HUMAN	ABHD14B	physical	26514267
ACTN1_HUMAN	ACTN1	physical	26514267
AMOL2_HUMAN	AMOTL2	physical	26514267
ASAP3_HUMAN	ASAP3	physical	26514267
KLH12_HUMAN	KLHL12	physical	26514267
DDX52_HUMAN	DDX52	physical	26514267
GALNS_HUMAN	GALNS	physical	26514267
HNRH1_HUMAN	HNRNPH1	physical	26514267
PK1L2_HUMAN	PKD1L2	physical	26514267

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D01438	Perlapine (JAN/USAN/INN); Hypnodin (TN)
D02689	Ramelteon (JAN/USAN/INN); Rozerem (TN)
D08170	Melatonin; Melatonina (TN)
D09388	Tasimelteon (USAN/INN)
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MTR1A_HUMAN

Related Literatures of Post-Translational Modification