S4A4_MOUSE - dbPTM
S4A4_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID S4A4_MOUSE
UniProt AC O88343
Protein Name Electrogenic sodium bicarbonate cotransporter 1
Gene Name Slc4a4
Organism Mus musculus (Mouse).
Sequence Length 1079
Subcellular Localization Basolateral cell membrane
Multi-pass membrane protein .
Protein Description Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.; Isoform 2: May have a higher activity than isoform 1..
Protein Sequence MEDEAVLDRGASFLKHVCDEEEVEGHHTIYIGVHVPKSYRRRRRHKRKAGHKEKKEKERISENYSDKSDVENADESSSSILKPLISPAAERIRFILGEEDDSPAPPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTCMEKGSIMLDREASSLPQLVEMIADHQIETGLLKPDLKDKVTYTLLRKHRHQTKKSNLRSLADIGKTVSSASRMFSNPDNGSPAMTHRNLTSSSLNDISDKPEKDQLKNKFMKKLPRDAEASNVLVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLFILLGPKGKAKSYHEIGRAIATLMSDEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWDPTIRIEPPKSLPSSDKRKNMYSGGENVQMNGDTPHDGGHGGGGHGDCEELQRTGRFCGGLIKDIKRKAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGDATDNMQGVLESFLGTAVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDHNFDYLEFRLWIGLWSAFMCLVLVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPINSDFKVGYNTHFSCACLPPDPVNLSVSNDTTLAPEDLPTISSTDMYHNVTFDWAYLSKKECVKYGGKLVGNNCDFVPDITLMSFILFLGTYTSSMAMKKFKTSRYFPTTARKLISDFAIILSILIFCVIDALVGVDTPKLIVPSEFKPTSPNRGWFVPPFGGNPWWVCLAAAIPALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVVCSFMALPWYVAATVISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGTLVFILTGLSVFMAPILKFIPMPVLYGVFLYMGVASLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVLCLALLWILKSTVAAIIFPVMILALVAVRKGMDYLFSQHDLSFLDDVIPEKDKKKKEDEKKKKKKKGSLDSDNDDSDCPYSEKVPSIKIPMDIMEQQPFLSDNKPLDRERSSTFLERHTSC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12PhosphorylationAVLDRGASFLKHVCD
HHHHHHHHHHHHHCC		33.6627149854
21 (in isoform 2)Phosphorylation-54.8421183079
21 (in isoform 3)Phosphorylation-54.8421183079
22 (in isoform 2)Phosphorylation-43.7721183079
22 (in isoform 3)Phosphorylation-43.7721183079
23 (in isoform 3)Phosphorylation-13.9421183079
23 (in isoform 2)Phosphorylation-13.9421183079
30PhosphorylationVEGHHTIYIGVHVPK
HCCCEEEEEEEECCH		7.8718034455
39 (in isoform 3)Phosphorylation-17.7921183079
39 (in isoform 2)Phosphorylation-17.7921183079
61PhosphorylationKKEKERISENYSDKS
HHHHHHHCCCCCCHH		26.4725177544
64PhosphorylationKERISENYSDKSDVE
HHHHCCCCCCHHHHC		17.7527818261
65PhosphorylationERISENYSDKSDVEN
HHHCCCCCCHHHHCC		50.5825521595
67UbiquitinationISENYSDKSDVENAD
HCCCCCCHHHHCCCC		42.4922790023
68PhosphorylationSENYSDKSDVENADE
CCCCCCHHHHCCCCC		52.4525521595
76PhosphorylationDVENADESSSSILKP
HHCCCCCCCCHHHHH		35.7523140645
77PhosphorylationVENADESSSSILKPL
HCCCCCCCCHHHHHH		26.5123140645
78PhosphorylationENADESSSSILKPLI
CCCCCCCCHHHHHHH		30.5823140645
79PhosphorylationNADESSSSILKPLIS
CCCCCCCHHHHHHHC		33.6123140645
86PhosphorylationSILKPLISPAAERIR
HHHHHHHCCHHHHHH		19.0322324799
137UbiquitinationRWIKFEEKVEQGGER
HHHHHHHHHHHCCCC		43.8222790023
146PhosphorylationEQGGERWSKPHVATL
HHCCCCCCCCCEEEE		42.4021183079
167UbiquitinationELRTCMEKGSIMLDR
HHHHHHHHCCEEECC		30.9522790023
197UbiquitinationQIETGLLKPDLKDKV
CCCCCCCCCCHHHHH		41.3422790023
203UbiquitinationLKPDLKDKVTYTLLR
CCCCHHHHHHHHHHH		34.5822790023
205PhosphorylationPDLKDKVTYTLLRKH
CCHHHHHHHHHHHHH		19.2720415495
206PhosphorylationDLKDKVTYTLLRKHR
CHHHHHHHHHHHHHC		9.8125195567
207PhosphorylationLKDKVTYTLLRKHRH
HHHHHHHHHHHHHCH		15.2220415495
219PhosphorylationHRHQTKKSNLRSLAD
HCHHCCHHCHHHHHH		42.5323984901
223PhosphorylationTKKSNLRSLADIGKT
CCHHCHHHHHHHCCH		30.9521082442
229UbiquitinationRSLADIGKTVSSASR
HHHHHHCCHHHHHHH		46.1922790023
230PhosphorylationSLADIGKTVSSASRM
HHHHHCCHHHHHHHH		22.0219060867
232PhosphorylationADIGKTVSSASRMFS
HHHCCHHHHHHHHHC		25.9726239621
233PhosphorylationDIGKTVSSASRMFSN
HHCCHHHHHHHHHCC		26.4026239621
235PhosphorylationGKTVSSASRMFSNPD
CCHHHHHHHHHCCCC		26.6519060867
239PhosphorylationSSASRMFSNPDNGSP
HHHHHHHCCCCCCCC		37.8026239621
245PhosphorylationFSNPDNGSPAMTHRN
HCCCCCCCCCCCCCC		18.7525521595
249PhosphorylationDNGSPAMTHRNLTSS
CCCCCCCCCCCCCCC		21.5724925903
254PhosphorylationAMTHRNLTSSSLNDI
CCCCCCCCCCCCCCC		30.0625521595
255PhosphorylationMTHRNLTSSSLNDIS
CCCCCCCCCCCCCCC		22.5425521595
256PhosphorylationTHRNLTSSSLNDISD
CCCCCCCCCCCCCCC		33.3425521595
257PhosphorylationHRNLTSSSLNDISDK
CCCCCCCCCCCCCCC		30.8425521595
262PhosphorylationSSSLNDISDKPEKDQ
CCCCCCCCCCCCHHH		42.3124925903
264UbiquitinationSLNDISDKPEKDQLK
CCCCCCCCCCHHHHH		48.5722790023
267UbiquitinationDISDKPEKDQLKNKF
CCCCCCCHHHHHHHH		60.3422790023
331UbiquitinationLFILLGPKGKAKSYH
EEEECCCCCCCCCHH		71.8422790023
336PhosphorylationGPKGKAKSYHEIGRA
CCCCCCCCHHHHHHH		36.2625195567
359UbiquitinationVFHDIAYKAKDRHDL
HHHHHHHHCCCHHHH		39.6822790023
395UbiquitinationTIRIEPPKSLPSSDK
CCCCCCCCCCCCCCC		75.2922790023
399PhosphorylationEPPKSLPSSDKRKNM
CCCCCCCCCCCCCCC		57.3625195567
404UbiquitinationLPSSDKRKNMYSGGE
CCCCCCCCCCCCCCC		52.3822790023
448UbiquitinationRFCGGLIKDIKRKAP
CCCCHHHHHHHHHCC		59.4522790023
641N-linked_GlycosylationPVNLSVSNDTTLAPE
CCEEEECCCCCCCCC		48.79-
661N-linked_GlycosylationSSTDMYHNVTFDWAY
CCCCCCCCEEEEEEC		19.62-
934UbiquitinationKLLLMPLKHQPDFIY
HHHHHHCCCCCCEEE		34.0322790023
969PhosphorylationALLWILKSTVAAIIF
HHHHHHHHHHHHHHH		25.35-
1026PhosphorylationKKKKKKGSLDSDNDD
HHHHHCCCCCCCCCC		37.5725521595
1029PhosphorylationKKKGSLDSDNDDSDC
HHCCCCCCCCCCCCC		43.5425521595
1034PhosphorylationLDSDNDDSDCPYSEK
CCCCCCCCCCCCCCC		43.9325521595
1038PhosphorylationNDDSDCPYSEKVPSI
CCCCCCCCCCCCCCC		35.4721183079
1039PhosphorylationDDSDCPYSEKVPSIK
CCCCCCCCCCCCCCC		18.9829899451
1044PhosphorylationPYSEKVPSIKIPMDI
CCCCCCCCCCCCCCH		39.2319060867
1046UbiquitinationSEKVPSIKIPMDIME
CCCCCCCCCCCCHHH		45.1322790023
1060PhosphorylationEQQPFLSDNKPLDRE
HCCCCCCCCCCCCHH		70.13-
1062UbiquitinationQPFLSDNKPLDRERS
CCCCCCCCCCCHHHH		52.5322790023
1064PhosphorylationFLSDNKPLDRERSST
CCCCCCCCCHHHHHH		11.78-
1067UbiquitinationDNKPLDRERSSTFLE
CCCCCCHHHHHHHHH		57.49-
1069PhosphorylationKPLDRERSSTFLERH
CCCCHHHHHHHHHHH		29.0425521595
1070PhosphorylationPLDRERSSTFLERHT
CCCHHHHHHHHHHHC		29.4225521595
1071PhosphorylationLDRERSSTFLERHTS
CCHHHHHHHHHHHCC		33.2221082442
1077PhosphorylationSTFLERHTSC-----
HHHHHHHCCC-----		37.70-
1078PhosphorylationTFLERHTSC------
HHHHHHCCC------		16.2323608596
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of S4A4_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
1026SPhosphorylation

21183079
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of S4A4_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of S4A4_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of S4A4_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-254; SER-257; SER-262;SER-1029 AND SER-1034, AND MASS SPECTROMETRY.
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1034, AND MASSSPECTROMETRY.
"Specific phosphopeptide enrichment with immobilized titanium ionaffinity chromatography adsorbent for phosphoproteome analysis.";
Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.;
J. Proteome Res. 7:3957-3967(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-254 AND SER-255, ANDMASS SPECTROMETRY.
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-30, AND MASSSPECTROMETRY.

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