dbPTM

PTX3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PTX3_HUMAN
UniProt AC	P26022
Protein Name	Pentraxin-related protein PTX3
Gene Name	PTX3
Organism	Homo sapiens (Human).
Sequence Length	381
Subcellular Localization	Secreted.
Protein Description	Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility..
Protein Sequence	MHLLAILFCALWSAVLAENSDDYDLMYVNLDNEIDNGLHPTEDPTPCACGQEHSEWDKLFIMLENSQMRERMLLQATDDVLRGELQRLREELGRLAESLARPCAPGAPAEARLTSALDELLQATRDAGRRLARMEGAEAQRPEEAGRALAAVLEELRQTRADLHAVQGWAARSWLPAGCETAILFPMRSKKIFGSVHPVRPMRLESFSACIWVKATDVLNKTILFSYGTKRNPYEIQLYLSYQSIVFVVGGEENKLVAEAMVSLGRWTHLCGTWNSEEGLTSLWVNGELAATTVEMATGHIVPEGGILQIGQEKNGCCVGGGFDETLAFSGRLTGFNIWDSVLSNEEIRETGGAESCHIRGNIVGWGVTEIQPHGGAQYVS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	O-linked_Glycosylation	IDNGLHPTEDPTPCA CCCCCCCCCCCCCCC	42.12	OGP
45	O-linked_Glycosylation	LHPTEDPTPCACGQE CCCCCCCCCCCCCCC	43.23	OGP
114	Phosphorylation	APAEARLTSALDELL CCHHHHHHHHHHHHH	13.34	29083192
115	Phosphorylation	PAEARLTSALDELLQ CHHHHHHHHHHHHHH	31.27	29083192
124	Phosphorylation	LDELLQATRDAGRRL HHHHHHHHHHHHHHH	19.00	29083192
159	Phosphorylation	VLEELRQTRADLHAV HHHHHHHHHHHHHHH	22.76	24670416
220	N-linked_Glycosylation	VKATDVLNKTILFSY EEHHHHCCCEEEEEC	38.99	UniProtKB CARBOHYD
222	Phosphorylation	ATDVLNKTILFSYGT HHHHCCCEEEEECCC	23.10	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PTX3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PTX3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PTX3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PTX3_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PTX3_HUMAN

Related Literatures of Post-Translational Modification