SLIT1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SLIT1_HUMAN
• UniProt AC: O75093
• Protein Name: Slit homolog 1 protein
• Gene Name: SLIT1
• Organism: Homo sapiens (Human).
• Sequence Length: 1534
• Subcellular Localization: Secreted.
• Protein Description: Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb..
• Protein Sequence: MALTPGWGSSAGPVRPELWLLLWAAAWRLGASACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYQLNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQDMEGKLLLTTPAKKFECQGPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPRANITLQVSTAEDNGILLYNGDNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVAFDQMVNLSIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVNSAAFRLWQILNGTGFHGCIRNLYINNELQDFTKTQMKPGVVPGCEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQESECRGDPVRDFHQVQRGYAICQTTRPLSWVECRGSCPGQGCCQGLRLKRRKFTFECSDGTSFAEEVEKPTKCGCALCA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MALTPGWGSSA ----CCCCCCCCCCC	27.15	25002506
9	Phosphorylation	ALTPGWGSSAGPVRP CCCCCCCCCCCCCCH	15.54	25002506
10	Phosphorylation	LTPGWGSSAGPVRPE CCCCCCCCCCCCCHH	33.05	25002506
72	N-linked_Glycosylation	RLELNGNNITRIHKN CEEECCCCCEEECCC	38.11	UniProtKB CARBOHYD
74	Phosphorylation	ELNGNNITRIHKNDF EECCCCCEEECCCCC	26.20	-
78	Acetylation	NNITRIHKNDFAGLK CCCEEECCCCCCHHH	56.70	7374123
78	Ubiquitination	NNITRIHKNDFAGLK CCCEEECCCCCCHHH	56.70	-
85	Acetylation	KNDFAGLKQLRVLQL CCCCCHHHHHHHHHH	46.50	7374133
85	Ubiquitination	KNDFAGLKQLRVLQL CCCCCHHHHHHHHHH	46.50	-
109	Ubiquitination	RGAFDDMKELERLRL HCCCCCHHHHHHHCC	67.17	-
160	Ubiquitination	FRGATDLKNLQLDKN HCCCCCCCCCCCCHH	59.42	-
166	Ubiquitination	LKNLQLDKNQISCIE CCCCCCCHHHCHHHH	60.38	-
192	N-linked_Glycosylation	VLTLNNNNITTIPVS EEEECCCCEEEEECH	34.80	UniProtKB CARBOHYD
298	Ubiquitination	GIVDCRGKGLTAIPA CEEECCCCCCCEECC	31.25	-
332	Phosphorylation	PPGAFSPYRKLRRID CCCCCCHHHCEECCC	21.12	-
406	N-linked_Glycosylation	DAFQDLQNLSLLSLY HHHHHHHHHHHHHHH	38.60	UniProtKB CARBOHYD
475	Acetylation	SPRRLANKRIGQIKS CHHHHCCCCCCCCCC	39.52	22361361
488	Phosphorylation	KSKKFRCSAKEQYFI CCCCCCCCCCCCEEC	37.81	-
493	Phosphorylation	RCSAKEQYFIPGTED CCCCCCCEECCCCCC	12.45	-
498	O-linked_Glycosylation	EQYFIPGTEDYQLNS CCEECCCCCCCCCCC	21.96	OGP
498	Phosphorylation	EQYFIPGTEDYQLNS CCEECCCCCCCCCCC	21.96	-
516	Ubiquitination	SDVVCPHKCRCEANV CCCCCCCCCCEECCE	14.44	-
533	Ubiquitination	CSSLKLTKIPERIPQ ECCCEECCCCCCCCC	67.70	-
553	Phosphorylation	RLNNNEISILEATGM ECCCCEEEHHHHHCH	18.23	-
565	Phosphorylation	TGMFKKLTHLKKINL HCHHHHHHCCEECCC	33.76	-
571	N-linked_Glycosylation	LTHLKKINLSNNKVS HHCCEECCCCCCCCE	46.42	UniProtKB CARBOHYD
630	N-linked_Glycosylation	NRISCIHNDSFTGLR CEEEEEECCCCCCCC	27.06	UniProtKB CARBOHYD
690	Ubiquitination	GGWLRKRKIVTGNPR HHHHHCEEEECCCCC	44.56	-
762	N-linked_Glycosylation	LPKGIPKNVTELYLD CCCCCCCCCEEEEEC	40.36	UniProtKB CARBOHYD
801	N-linked_Glycosylation	NKISSLSNSSFTNMS CCCHHHCCCCCCCHH	47.14	UniProtKB CARBOHYD
806	N-linked_Glycosylation	LSNSSFTNMSQLTTL HCCCCCCCHHHHHHH	26.54	UniProtKB CARBOHYD
882	Ubiquitination	RWLSSWVKTGYKEPG HHHHHHHHHCCCCCC	29.94	-
911	Ubiquitination	LLTTPAKKFECQGPP EEECCCHHCCCCCCC	48.80	-
1026	N-linked_Glycosylation	VCVDGVGNYTCQCPL EEECCCCCEEEECCC	26.91	UniProtKB CARBOHYD
1079	N-linked_Glycosylation	MPGYAGDNCSENQDD CCCCCCCCCCCCCHH	30.23	UniProtKB CARBOHYD
1175	Phosphorylation	VNFVDRDTYLQFTDL CCEECCCCEEEEECC	27.33	25599653
1189	N-linked_Glycosylation	LQNWPRANITLQVST CCCCCCCCEEEEEEE	29.11	UniProtKB CARBOHYD
1259	N-linked_Glycosylation	VAFDQMVNLSIDGGS EEECCCCCEEECCCC	23.80	UniProtKB CARBOHYD
1306	N-linked_Glycosylation	FRLWQILNGTGFHGC HHHHHHHHCCCCCHH	47.84	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SLIT1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SLIT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SLIT1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SLIT1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.