UCHL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UCHL1_MOUSE
• UniProt AC: Q9R0P9
• Protein Name: Ubiquitin carboxyl-terminal hydrolase isozyme L1
• Gene Name: Uchl1
• Organism: Mus musculus (Mouse).
• Sequence Length: 223
• Subcellular Localization: Cytoplasm . Endoplasmic reticulum membrane; Lipid-anchor.
• Protein Description: Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity..
• Protein Sequence: MQLKPMEINPEMLNKVLAKLGVAGQWRFADVLGLEEETLGSVPSPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLEFEDGSVLKQFLSETEKLSPEDRAKCFEKNEAIQAAHDSVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDSLLQDAAKVCREFTEREQGEVRFSAVALCKAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Ubiquitination	----MQLKPMEINPE ----CCCCCCCCCHH	25.98	22790023
15	Ubiquitination	INPEMLNKVLAKLGV CCHHHHHHHHHHHCC	34.36	22790023
19	Ubiquitination	MLNKVLAKLGVAGQW HHHHHHHHHCCCCCC	41.43	22790023
19	Acetylation	MLNKVLAKLGVAGQW HHHHHHHHHCCCCCC	41.43	22826441
65	Ubiquitination	QHENFRKKQIEELKG CCCCHHHHHHHHHCC	52.86	27667366
71	Ubiquitination	KKQIEELKGQEVSPK HHHHHHHCCCCCCHH	62.92	22790023
76	Phosphorylation	ELKGQEVSPKVYFMK HHCCCCCCHHHEEEE	20.46	28066266
78	Ubiquitination	KGQEVSPKVYFMKQT CCCCCCHHHEEEECC	41.90	22790023
90	S-palmitoylation	KQTIGNSCGTIGLIH ECCCCCCHHHHHHHH	6.90	28680068
90	S-nitrosylation	KQTIGNSCGTIGLIH ECCCCCCHHHHHHHH	6.90	24895380
119	Phosphorylation	SVLKQFLSETEKLSP HHHHHHHHHHHCCCH	43.70	28066266
121	Phosphorylation	LKQFLSETEKLSPED HHHHHHHHHCCCHHH	34.74	28066266
123	Ubiquitination	QFLSETEKLSPEDRA HHHHHHHCCCHHHHH	62.78	22790023
123	Acetylation	QFLSETEKLSPEDRA HHHHHHHCCCHHHHH	62.78	22826441
125	Phosphorylation	LSETEKLSPEDRAKC HHHHHCCCHHHHHHH	36.99	22324799
135	Ubiquitination	DRAKCFEKNEAIQAA HHHHHHHHHHHHHHH	39.57	22790023
135	Acetylation	DRAKCFEKNEAIQAA HHHHHHHHHHHHHHH	39.57	22826441
145	Phosphorylation	AIQAAHDSVAQEGQC HHHHHCHHHHHCCCC	14.97	29899451
152	S-nitrosocysteine	SVAQEGQCRVDDKVN HHHHCCCCCCCCCEE	7.23	-
152	S-nitrosylation	SVAQEGQCRVDDKVN HHHHCCCCCCCCCEE	7.23	24895380
157	Ubiquitination	GQCRVDDKVNFHFIL CCCCCCCCEEEEEEE	34.32	-
188	Phosphorylation	FPVNHGASSEDSLLQ CCCCCCCCCHHHHHH	38.56	25293948
189	Phosphorylation	PVNHGASSEDSLLQD CCCCCCCCHHHHHHH	44.91	25293948
192	Phosphorylation	HGASSEDSLLQDAAK CCCCCHHHHHHHHHH	27.25	25293948
199	Acetylation	SLLQDAAKVCREFTE HHHHHHHHHHHHHHH	43.52	22826441
220	Farnesylation	RFSAVALCKAA---- EEEEEHHHHCC----	1.71	-
220	S-nitrosylation	RFSAVALCKAA---- EEEEEHHHHCC----	1.71	24895380

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UCHL1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UCHL1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UCHL1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBC_MOUSE	Ubc	physical	12913066
PTOV1_MOUSE	Ptov1	physical	21678139
CDK1_MOUSE	Cdk1	physical	21678139
TBA1A_MOUSE	Tuba1a	physical	18250096
CSN5_MOUSE	Cops5	physical	19377830

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.