PTOV1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTOV1_MOUSE
• UniProt AC: Q91VU8
• Protein Name: Prostate tumor-overexpressed gene 1 protein homolog
• Gene Name: Ptov1
• Organism: Mus musculus (Mouse).
• Sequence Length: 416
• Subcellular Localization: Cell membrane. Cytoplasm, perinuclear region. Nucleus. Translocates from the cytoplasm to the nucleus at the onset of S-phase. Also localizes to lipid rafts..
• Protein Description: May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation (By similarity)..
• Protein Sequence: MVRPRRAPHRSGAGGPLGGRGRPPRPLVVRAVRSRSWPGGPRGPQPPRIRARSAPPMEGARVFGALGPIGPSSPGLTLGGLAVNEHRLSNKLLAWSGVLEWQEKRRPFSDSTAKLKRTLPCQAYVNQGENLETDQWPQKLIMQLIPQQLLTTLGPLFRNSQLAQFHFTNRDCDSLKGLCRIMGNGFAGCMLFPHISPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNAIRQVITTRKQAVGPGGVHSGPVQIVNNKFLAWSGVMEWQEPRPEPNSRSKRWLPSHVYVNQGEILRTDQWPRRLFMQLIPQQLLTTLVPLFRNSRLVQFHFTKDMETLKSLCRIMDNGFAGCVHFSYKASCEVRVLMLLYSSEKKIFIGLIPHDQSNFVNGIRRVIANQQQVLQRSLEQEQQQRGMGG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Phosphorylation	LVVRAVRSRSWPGGP EEEEEECCCCCCCCC	24.86	23984901
36	Phosphorylation	VRAVRSRSWPGGPRG EEEECCCCCCCCCCC	38.58	23684622
53	Phosphorylation	PPRIRARSAPPMEGA CCCCCCCCCCCCCCC	44.11	25521595
72	Phosphorylation	ALGPIGPSSPGLTLG ECCCCCCCCCCCCCC	43.91	26643407
73	Phosphorylation	LGPIGPSSPGLTLGG CCCCCCCCCCCCCCC	26.56	26824392
77	Phosphorylation	GPSSPGLTLGGLAVN CCCCCCCCCCCEEEC	29.31	23984901
89	Phosphorylation	AVNEHRLSNKLLAWS EECCHHHHHCHHHHH	31.69	25777480
114	Ubiquitination	PFSDSTAKLKRTLPC CCCCCHHHHHHHCCC	55.41	-
176	Ubiquitination	NRDCDSLKGLCRIMG CCCHHHHHHHHHHHC	54.51	22790023
207	Phosphorylation	VRVLMLLYSSKKKIF HHHHHHHHHCCCEEE	13.62	29472430
208	Phosphorylation	RVLMLLYSSKKKIFM HHHHHHHHCCCEEEE	35.33	29472430
209	Phosphorylation	VLMLLYSSKKKIFMG HHHHHHHCCCEEEEE	34.63	29472430
237	Ubiquitination	RQVITTRKQAVGPGG HHHHHHCCCCCCCCC	40.28	22790023
275	Phosphorylation	EPRPEPNSRSKRWLP CCCCCCCCCCCCCCC	48.96	-
277	Phosphorylation	RPEPNSRSKRWLPSH CCCCCCCCCCCCCCC	26.79	-
283	Phosphorylation	RSKRWLPSHVYVNQG CCCCCCCCCEEECCC	24.34	26239621
286	Phosphorylation	RWLPSHVYVNQGEIL CCCCCCEEECCCCEE	6.56	26239621
331	Ubiquitination	LVQFHFTKDMETLKS EEEEEECCCHHHHHH	54.88	22790023
337	Ubiquitination	TKDMETLKSLCRIMD CCCHHHHHHHHHHHH	49.12	22790023
368	Phosphorylation	VRVLMLLYSSEKKIF HHEHHHHHCCCCEEE	13.24	25338131
369	Phosphorylation	RVLMLLYSSEKKIFI HEHHHHHCCCCEEEE	31.80	25338131
370	Phosphorylation	VLMLLYSSEKKIFIG EHHHHHCCCCEEEEE	39.62	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTOV1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTOV1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTOV1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PTOV1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.