QOR_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: QOR_MOUSE
• UniProt AC: P47199
• Protein Name: Quinone oxidoreductase
• Gene Name: Cryz
• Organism: Mus musculus (Mouse).
• Sequence Length: 331
• Subcellular Localization: Cytoplasm.
• Protein Description: Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding (By similarity)..
• Protein Sequence: MATGQKLMRAIRVFEFGGPEVLKLQSDVVVPVPQSHQVLIKVHACGVNPVETYIRSGAYSRKPALPYTPGSDVAGIIESVGDKVSAFKKGDRVFCYSTVSGGYAEFALAADDTIYPLPETLNFRQGAALGIPYFTACRALFHSARARAGESVLVHGASGGVGLATCQIARAHGLKVLGTAGSEEGKKLVLQNGAHEVFNHKEANYIDKIKMSVGDKDKGVDVIIEMLANENLSNDLKLLSHGGRVVVVGCRGPIEINPRDTMAKETSIIGVSLSSSTKEEFQQFAGLLQAGIEKGWVKPVIGSEYPLEKAAQAHEDIIHGSGKTGKMILLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATGQKLMR ------CCHHHHHHH	22.04	-
6	Malonylation	--MATGQKLMRAIRV --CCHHHHHHHHHHH	45.66	26320211
23	Acetylation	FGGPEVLKLQSDVVV CCCHHHEEECCCEEE	50.05	23954790
35	Phosphorylation	VVVPVPQSHQVLIKV EEEECCCCCEEEEEE	15.15	25521595
53	Phosphorylation	GVNPVETYIRSGAYS CCCCCHHHHHCCCCC	4.84	25195567
62	Ubiquitination	RSGAYSRKPALPYTP HCCCCCCCCCCCCCC	28.80	22790023
67	Phosphorylation	SRKPALPYTPGSDVA CCCCCCCCCCCCCHH	26.81	25521595
83	Acetylation	IIESVGDKVSAFKKG HHHHHHCHHHHHCCC	31.96	23806337
83	Succinylation	IIESVGDKVSAFKKG HHHHHHCHHHHHCCC	31.96	23806337
88	Acetylation	GDKVSAFKKGDRVFC HCHHHHHCCCCEEEE	56.41	155745
89	Acetylation	DKVSAFKKGDRVFCY CHHHHHCCCCEEEEE	60.64	7826009
137	S-palmitoylation	GIPYFTACRALFHSA CCCHHHHHHHHHHHH	2.07	26165157
165	Phosphorylation	SGGVGLATCQIARAH CCCHHHHHHHHHHHC	15.24	-
186	Acetylation	TAGSEEGKKLVLQNG ECCCHHHHEEEECCC	46.33	23576753
186	Malonylation	TAGSEEGKKLVLQNG ECCCHHHHEEEECCC	46.33	26320211
186	Succinylation	TAGSEEGKKLVLQNG ECCCHHHHEEEECCC	46.33	23806337
187	Ubiquitination	AGSEEGKKLVLQNGA CCCHHHHEEEECCCH	55.47	22790023
201	Acetylation	AHEVFNHKEANYIDK HHHHCCCCCCCCHHE	60.67	23954790
208	Ubiquitination	KEANYIDKIKMSVGD CCCCCHHEEECCCCC	34.37	-
208	Succinylation	KEANYIDKIKMSVGD CCCCCHHEEECCCCC	34.37	-
208	Acetylation	KEANYIDKIKMSVGD CCCCCHHEEECCCCC	34.37	23806337
208	Malonylation	KEANYIDKIKMSVGD CCCCCHHEEECCCCC	34.37	26320211
210	Malonylation	ANYIDKIKMSVGDKD CCCHHEEECCCCCCC	30.75	26320211
216	Acetylation	IKMSVGDKDKGVDVI EECCCCCCCCCHHHH	56.25	23201123
237	Acetylation	ENLSNDLKLLSHGGR CCCCHHHHHHHCCCE	50.69	23954790
272	Phosphorylation	ETSIIGVSLSSSTKE CCEEEEEECCCCCHH	19.81	25177544
274	Phosphorylation	SIIGVSLSSSTKEEF EEEEEECCCCCHHHH	18.09	28464351
275	Phosphorylation	IIGVSLSSSTKEEFQ EEEEECCCCCHHHHH	47.52	25195567
294	Acetylation	LLQAGIEKGWVKPVI HHHHCHHHCCCCCCC	57.03	23954790
298	Succinylation	GIEKGWVKPVIGSEY CHHHCCCCCCCCCCC	27.36	23806337
298	Succinylation	GIEKGWVKPVIGSEY CHHHCCCCCCCCCCC	27.36	-
298	Acetylation	GIEKGWVKPVIGSEY CHHHCCCCCCCCCCC	27.36	23806337
321	Phosphorylation	HEDIIHGSGKTGKMI CCCCCCCCCCCCCEE	23.97	30352176

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of QOR_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of QOR_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of QOR_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of QOR_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.