CJ090_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CJ090_HUMAN
• UniProt AC: Q96M02
• Protein Name: Centrosomal protein C10orf90
• Gene Name: C10orf90
• Organism: Homo sapiens (Human).
• Sequence Length: 699
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Localizes to the actin cytoskeleton in a proportion of cells. Colocalizes with centriolar acetylated tubulin.
• Protein Description: Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner (By similarity). May have a role in the assembly of primary cilia..
• Protein Sequence: MLKLSGEGLRDSYHSRRDQIALKNLQSDVTEAKSDFTKETLASQNTKMISSIVISQMIDENKSRENRASLPLPCAIAQSRAHHAKQSLANRSGVNIHRAFALLPGRLGIPAPSDERGPEAELPPKEERPCGGPRRGFASITITARRVGPPARALVWGTAGDSLCPKCRAEDTLFQAPPALANGAHPGRHQRSFACTEFSRNSSVVRLKVPEAHTGLCERRKYWVTHADDKETSFSPDTPLSGKSPLVFSSCVHLRVSQQCPDSIYYVDKSLSVPIEPPQIASPKMHRSVLSLNLNCSSHRLTADGVDGLVNREPISEALKQELLEGDQDLVGQRWNPGLQESHLKETPSLRRVHLGTGACPWSGSFPLENTELANVGANQVTVRKGEKDHTTHCHASDHANQLSIHIPGWSYRAVHTKVFSGSSKRQQGEVCMTVSAPPVEQKPTRHFLPIGDSSPSDDCLSRDLSEPTERRHQSFLKPRILFPGFLCPLQDVCASLQEDNGVQIESKFPKGDYTCCDLVVKIKECKKSEDPTTPEPSPAAPSPAPRDGAGSPGLSEDCSESQQTPARSLTLQEALEVRKPQFISRSQERLKKLEHMVQQRKAQRKEDLRQKQSLLPIRTSKKQFTIPHPLSDNLFKPKERCISEKEMHMRSKRIYDNLPEVKKKKEEQRKRVILQSNRLRAEVFKKQLLDQLLQRNAV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	SGEGLRDSYHSRRDQ CCCCCHHCHHCHHHH	20.50	27251275
13	Phosphorylation	GEGLRDSYHSRRDQI CCCCHHCHHCHHHHH	14.22	27251275
15	Phosphorylation	GLRDSYHSRRDQIAL CCHHCHHCHHHHHHH	22.30	27251275
50	Phosphorylation	SQNTKMISSIVISQM HCCHHHHHHHHHHHH	15.54	28509920
51	Phosphorylation	QNTKMISSIVISQMI CCHHHHHHHHHHHHH	15.22	28509920
55	Phosphorylation	MISSIVISQMIDENK HHHHHHHHHHHCCCC	11.64	22199227
63	Phosphorylation	QMIDENKSRENRASL HHHCCCCCCCCCCCC	57.31	29083192
87	Phosphorylation	RAHHAKQSLANRSGV HHHHHHHHHHHCCCC	28.83	22210691
222	Phosphorylation	GLCERRKYWVTHADD CCCCCCCEEEEECCC	11.87	-
232	Phosphorylation	THADDKETSFSPDTP EECCCCCCCCCCCCC	40.59	29083192
233	Phosphorylation	HADDKETSFSPDTPL ECCCCCCCCCCCCCC	25.48	29083192
235	Phosphorylation	DDKETSFSPDTPLSG CCCCCCCCCCCCCCC	22.95	29083192
238	Phosphorylation	ETSFSPDTPLSGKSP CCCCCCCCCCCCCCC	29.52	29083192
241	Phosphorylation	FSPDTPLSGKSPLVF CCCCCCCCCCCCEEE	45.43	29083192
270	Phosphorylation	SIYYVDKSLSVPIEP CEEEEECCCCCCCCC	22.78	-
272	Phosphorylation	YYVDKSLSVPIEPPQ EEEECCCCCCCCCCC	32.70	-
282	Phosphorylation	IEPPQIASPKMHRSV CCCCCCCCHHHCCCC	27.04	28348404
349	Phosphorylation	SHLKETPSLRRVHLG HHCCCCCCCCEEECC	41.76	24719451
382	Phosphorylation	NVGANQVTVRKGEKD ECCCCEEEEECCCCC	12.58	24719451
418	Ubiquitination	SYRAVHTKVFSGSSK CEEEEEEEEEECCCC	26.80	29967540
434	Phosphorylation	QQGEVCMTVSAPPVE CCCCEEEEEECCCCC	13.24	30631047
457	Phosphorylation	PIGDSSPSDDCLSRD CCCCCCCCCCHHCCC	48.29	-
475	Phosphorylation	PTERRHQSFLKPRIL CCHHHHHHCCCCCCC	26.82	24719451
529	Phosphorylation	KIKECKKSEDPTTPE EHHHHCCCCCCCCCC	32.50	-
534	Phosphorylation	KKSEDPTTPEPSPAA CCCCCCCCCCCCCCC	30.92	-
543	Phosphorylation	EPSPAAPSPAPRDGA CCCCCCCCCCCCCCC	29.03	27732954
552	Phosphorylation	APRDGAGSPGLSEDC CCCCCCCCCCCCCCC	18.43	29507054
620	Phosphorylation	QSLLPIRTSKKQFTI HHCCCCCCCCCCEEC	45.69	-
626	Phosphorylation	RTSKKQFTIPHPLSD CCCCCCEECCCCCCC	30.98	-
639	Acetylation	SDNLFKPKERCISEK CCCCCCCHHHCCCHH	59.38	7665225
644	O-linked_Glycosylation	KPKERCISEKEMHMR CCHHHCCCHHHHHHH	46.36	30379171
652	Phosphorylation	EKEMHMRSKRIYDNL HHHHHHHHHHHHHCC	20.79	27251275
653	Ubiquitination	KEMHMRSKRIYDNLP HHHHHHHHHHHHCCH	32.24	-
656	Phosphorylation	HMRSKRIYDNLPEVK HHHHHHHHHCCHHHH	11.65	27251275
663	Ubiquitination	YDNLPEVKKKKEEQR HHCCHHHHHHHHHHH	58.16	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CJ090_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CJ090_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CJ090_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
P53_HUMAN	TP53	physical	24240685
P53_HUMAN	TP53	physical	26223354

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.