dbPTM

SOX11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SOX11_HUMAN
UniProt AC	P35716
Protein Name	Transcription factor SOX-11
Gene Name	SOX11
Organism	Homo sapiens (Human).
Sequence Length	441
Subcellular Localization	Nucleus .
Protein Description	Transcriptional factor involved in the embryonic neurogenesis. May also have a role in tissue modeling during development..
Protein Sequence	MVQQAESLEAESNLPREALDTEEGEFMACSPVALDESDPDWCKTASGHIKRPMNAFMVWSKIERRKIMEQSPDMHNAEISKRLGKRWKMLKDSEKIPFIREAERLRLKHMADYPDYKYRPRKKPKMDPSAKPSASQSPEKSAAGGGGGSAGGGAGGAKTSKGSSKKCGKLKAPAAAGAKAGAGKAAQSGDYGGAGDDYVLGSLRVSGSGGGGAGKTVKCVFLDEDDDDDDDDDELQLQIKQEPDEEDEEPPHQQLLQPPGQQPSQLLRRYNVAKVPASPTLSSSAESPEGASLYDEVRAGATSGAGGGSRLYYSFKNITKQHPPPLAQPALSPASSRSVSTSSSSSSGSSSGSSGEDADDLMFDLSLNFSQSAHSASEQQLGGGAAAGNLSLSLVDKDLDSFSEGSLGSHFEFPDYCTPELSEMIAGDWLEANFSDLVFTY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MVQQAESLEAESNL -CCHHHHHHHHHHCC	34.23	24043423
12	Phosphorylation	AESLEAESNLPREAL HHHHHHHHCCCHHHH	51.19	24043423
30	Phosphorylation	EGEFMACSPVALDES CCCEEEECCEECCCC	16.93	27732954
37	Phosphorylation	SPVALDESDPDWCKT CCEECCCCCCCHHHH	54.86	27732954
60	Phosphorylation	MNAFMVWSKIERRKI CHHHHHHHHHHHHHH	16.61	-
71	Phosphorylation	RRKIMEQSPDMHNAE HHHHHHHCCCHHHHH	15.01	22199227
81	Ubiquitination	MHNAEISKRLGKRWK HHHHHHHHHHHHHHH	58.25	-
108	Ubiquitination	EAERLRLKHMADYPD HHHHHCHHHHHCCCC	25.54	-
113	Phosphorylation	RLKHMADYPDYKYRP CHHHHHCCCCCCCCC	6.62	22817900
116	Phosphorylation	HMADYPDYKYRPRKK HHHCCCCCCCCCCCC	12.86	18083107
117	Ubiquitination	MADYPDYKYRPRKKP HHCCCCCCCCCCCCC	42.01	-
129	Phosphorylation	KKPKMDPSAKPSASQ CCCCCCCCCCCCCCC	44.66	21406692
133	Phosphorylation	MDPSAKPSASQSPEK CCCCCCCCCCCCCCC	39.59	21406692
135	Phosphorylation	PSAKPSASQSPEKSA CCCCCCCCCCCCCCC	35.21	21406692
137	Phosphorylation	AKPSASQSPEKSAAG CCCCCCCCCCCCCCC	32.31	19664995
158	Acetylation	GGGAGGAKTSKGSSK CCCCCCCCCCCCCCC	57.51	7709615
159	Phosphorylation	GGAGGAKTSKGSSKK CCCCCCCCCCCCCCC	34.83	-
163	Phosphorylation	GAKTSKGSSKKCGKL CCCCCCCCCCCCCCC	42.60	-
202	Phosphorylation	GDDYVLGSLRVSGSG CCCEEEEEEEEECCC	14.61	24719451
206	Phosphorylation	VLGSLRVSGSGGGGA EEEEEEEECCCCCCC	22.32	18669648
278	Phosphorylation	NVAKVPASPTLSSSA CCCCCCCCCCCCCCC	16.61	15345747
280	Phosphorylation	AKVPASPTLSSSAES CCCCCCCCCCCCCCC	36.46	27732954
282	Phosphorylation	VPASPTLSSSAESPE CCCCCCCCCCCCCCC	25.40	27732954
283	Phosphorylation	PASPTLSSSAESPEG CCCCCCCCCCCCCCC	36.36	27732954
284	Phosphorylation	ASPTLSSSAESPEGA CCCCCCCCCCCCCCC	32.45	24173317
287	Phosphorylation	TLSSSAESPEGASLY CCCCCCCCCCCCCHH	28.15	27732954
292	Phosphorylation	AESPEGASLYDEVRA CCCCCCCCHHHHHHH	38.02	27732954
294	Phosphorylation	SPEGASLYDEVRAGA CCCCCCHHHHHHHCC	13.94	27732954
316	Ubiquitination	SRLYYSFKNITKQHP CCEEEECCCCCCCCC	41.31	32142685
332	Phosphorylation	PLAQPALSPASSRSV CCCCCCCCCCCCCCC	22.11	27732954
335	Phosphorylation	QPALSPASSRSVSTS CCCCCCCCCCCCCCC	29.66	27732954
336	Phosphorylation	PALSPASSRSVSTSS CCCCCCCCCCCCCCC	30.59	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SOX11_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SOX11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SOX11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SOX11_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615866	Mental retardation, autosomal dominant 27 (MRD27)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SOX11_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206, AND MASSSPECTROMETRY.	18669648 [Abstract]