CO9A2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CO9A2_HUMAN
• UniProt AC: Q14055
• Protein Name: Collagen alpha-2(IX) chain
• Gene Name: COL9A2
• Organism: Homo sapiens (Human).
• Sequence Length: 689
• Subcellular Localization: Secreted, extracellular space, extracellular matrix.
• Protein Description: Structural component of hyaline cartilage and vitreous of the eye..
• Protein Sequence: MAAATASPRSLLVLLQVVVLALAQIRGPPGERGPPGPPGPPGVPGSDGIDGDNGPPGKAGPPGPKGEPGKAGPDGPDGKPGIDGLTGAKGEPGPMGIPGVKGQPGLPGPPGLPGPGFAGPPGPPGPVGLPGEIGIRGPKGDPGPDGPSGPPGPPGKPGRPGTIQGLEGSADFLCPTNCPPGMKGPPGLQGVKGHAGKRGILGDPGHQGKPGPKGDVGASGEQGIPGPPGPQGIRGYPGMAGPKGETGPHGYKGMVGAIGATGPPGEEGPRGPPGRAGEKGDEGSPGIRGPQGITGPKGATGPPGINGKDGTPGTPGMKGSAGQAGQPGSPGHQGLAGVPGQPGTKGGPGDQGEPGPQGLPGFSGPPGKEGEPGPRGEIGPQGIMGQKGDQGERGPVGQPGPQGRQGPKGEQGPPGIPGPQGLPGVKGDKGSPGKTGPRGKVGDPGVAGLPGEKGEKGESGEPGPKGQQGVRGEPGYPGPSGDAGAPGVQGYPGPPGPRGLAGNRGVPGQPGRQGVEGRDATDQHIVDVALKMLQEQLAEVAVSAKREALGAVGMMGPPGPPGPPGYPGKQGPHGHPGPRGVPGIVGAVGQIGNTGPKGKRGEKGDPGEVGRGHPGMPGPPGIPGLPGRPGQAINGKDGDRGSPGAPGEAGRPGLPGPVGLPGFCEPAACLGASAYASARLTEPGSIKGP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MAAATASPRSLLVL -CCCCCCCHHHHHHH	19.25	-
10	Phosphorylation	AATASPRSLLVLLQV CCCCCHHHHHHHHHH	29.46	-
160	Hydroxylation	PPGKPGRPGTIQGLE CCCCCCCCCCCCCCC	50.63	-
169	O-linked_Glycosylation	TIQGLEGSADFLCPT CCCCCCCCCCEECCC	18.45	-
183	O-linked_Glycosylation	TNCPPGMKGPPGLQG CCCCCCCCCCCCCCC	74.34	-
183	Hydroxylation	TNCPPGMKGPPGLQG CCCCCCCCCCCCCCC	74.34	-
252	Acetylation	ETGPHGYKGMVGAIG CCCCCCCCCCCCCCC	45.16	7479769
279	Acetylation	PPGRAGEKGDEGSPG CCCCCCCCCCCCCCC	71.40	7479779
300	Phosphorylation	ITGPKGATGPPGING CCCCCCCCCCCCCCC	59.91	28674151
320	Phosphorylation	GTPGMKGSAGQAGQP CCCCCCCCCCCCCCC	24.57	28450419
329	Phosphorylation	GQAGQPGSPGHQGLA CCCCCCCCCCCCCCC	34.10	26657352
344	Phosphorylation	GVPGQPGTKGGPGDQ CCCCCCCCCCCCCCC	32.95	28450419
431	Phosphorylation	GVKGDKGSPGKTGPR CCCCCCCCCCCCCCC	35.90	24719451
459	Phosphorylation	EKGEKGESGEPGPKG CCCCCCCCCCCCCCC	58.06	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CO9A2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CO9A2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CO9A2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NOA1_HUMAN	NOA1	physical	16169070
FEZ1_HUMAN	FEZ1	physical	16169070
HAP1_HUMAN	HAP1	physical	16169070

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 600204: Multiple epiphyseal dysplasia 2 (EDM2)
• 603932: Intervertebral disc disease (IDD)
• 614284: Stickler syndrome 5 (STL5)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.