RGS12_HUMAN - dbPTM
RGS12_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RGS12_HUMAN
UniProt AC O14924
Protein Name Regulator of G-protein signaling 12
Gene Name RGS12
Organism Homo sapiens (Human).
Sequence Length 1447
Subcellular Localization Nucleus . Cytoplasm . Cell projection, dendrite . Cell junction, synapse .
Isoform 5: Nucleus matrix . Also localized to discrete nuclear foci that are distinct from sites of RNA processing, PML nuclear bodies, and PcG domains.
Protein Description Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form.; Isoform 5: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis..
Protein Sequence MFRAGEASKRPLPGPSPPRVRSVEVARGRAGYGFTLSGQAPCVLSCVMRGSPADFVGLRAGDQILAVNEINVKKASHEDVVKLIGKCSGVLHMVIAEGVGRFESCSSDEEGGLYEGKGWLKPKLDSKALGINRAERVVEEMQSGGIFNMIFENPSLCASNSEPLKLKQRSLSESAATRFDVGHESINNPNPNMLSKEEISKVIHDDSVFSIGLESHDDFALDASILNVAMIVGYLGSIELPSTSSNLESDSLQAIRGCMRRLRAEQKIHSLVTMKIMHDCVQLSTDKAGVVAEYPAEKLAFSAVCPDDRRFFGLVTMQTNDDGSLAQEEEGALRTSCHVFMVDPDLFNHKIHQGIARRFGFECTADPDTNGCLEFPASSLPVLQFISVLYRDMGELIEGMRARAFLDGDADAHQNNSTSSNSDSGIGNFHQEEKSNRVLVVDLGGSSSRHGPGGSAWDGVGGRGAQPWGAPWTGPFCPDPEGSPPFEAAHQTDRFWDLNKHLGPASPVEVPPASLRSSVPPSKRGTVGAGCGFNQRWLPVHVLREWQCGHTSDQDSYTDSTDGWSSINCGTLPPPMSKIPADRYRVEGSFAQPPLNAPKREWSRKAFGMQSIFGPHRNVRKTKEDKKGSKFGRGTGLTQPSQRTSARRSFGRSKRFSITRSLDDLESATVSDGELTGADLKDCVSNNSLSSNASLPSVQSCRRLRERRVASWAVSFERLLQDPVGVRYFSDFLRKEFSEENILFWQACEYFNHVPAHDKKELSYRAREIFSKFLCSKATTPVNIDSQAQLADDVLRAPHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQECILAEVEGRALPDSQQVPSSPASKHSLGSDHSSVSTPKKLSGKSKSGRSLNEELGDEDSEKKRKGAFFSWSRTRSTGRSQKKREHGDHADDALHANGGLCRRESQGSVSSAGSLDLSEACRTLAPEKDKATKHCCIHLPDGTSCVVAVKAGFSIKDILSGLCERHGINGAAADLFLVGGDKPLVLHQDSSILESRDLRLEKRTLFRLDLVPINRSVGLKAKPTKPVTEVLRPVVARYGLDLSGLLVRLSGEKEPLDLGAPISSLDGQRVVLEEKDPSRGKASADKQKGVPVKQNTAVNSSSRNHSATGEERTLGKSNSIKIKGENGKNARDPRLSKREESIAKIGKKKYQKINLDEAEEFFELISKAQSNRADDQRGLLRKEDLVLPEFLRLPPGSTELTLPTPAAVAKGFSKRSATGNGRESASQPGEQWEPVQESSDSPSTSPGSASSPPGPPGTTPPGQKSPSGPFCTPQSPVSLAQEGTAQIWKRQSQEVEAGGIQTVEDEHVAELTLMGEGDISSPNSTLLPPPSTPQEVPGPSRPGSGTHGSRDLPVNRIIDVDLVTGSAPGRDGGIAGAQAGPGRSQASGGPPTSDLPGLGPVPGEPAKPKTSAHHATFV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2 (in isoform 2)Phosphorylation-12.4724043423
2 (in isoform 7)Phosphorylation-12.4724043423
4 (in isoform 2)Phosphorylation-26.0524043423
4 (in isoform 7)Phosphorylation-26.0524043423
9 (in isoform 2)Phosphorylation-66.1524043423
9 (in isoform 7)Phosphorylation-66.1524043423
11 (in isoform 2)Phosphorylation-46.7924043423
11 (in isoform 7)Phosphorylation-46.7924043423
13 (in isoform 2)Phosphorylation-56.1624043423
13 (in isoform 7)Phosphorylation-56.1624043423
16PhosphorylationKRPLPGPSPPRVRSV
CCCCCCCCCCCEEEE		54.1530266825
18 (in isoform 2)Phosphorylation-52.3024043423
18 (in isoform 7)Phosphorylation-52.3024043423
82UbiquitinationASHEDVVKLIGKCSG
CCHHHHHHHHHHCHH		33.9529967540
88PhosphorylationVKLIGKCSGVLHMVI
HHHHHHCHHHHHHHE		35.1117287340
104PhosphorylationEGVGRFESCSSDEEG
ECCCCEECCCCCCCC		19.3125850435
106PhosphorylationVGRFESCSSDEEGGL
CCCEECCCCCCCCCC		50.5325849741
107PhosphorylationGRFESCSSDEEGGLY
CCEECCCCCCCCCCC		54.0625849741
114PhosphorylationSDEEGGLYEGKGWLK
CCCCCCCCCCCCCCC		26.3829449344
127UbiquitinationLKPKLDSKALGINRA
CCCCCCHHHHCCCHH		47.5029967540
129UbiquitinationPKLDSKALGINRAER
CCCCHHHHCCCHHHH		8.9929967540
170PhosphorylationPLKLKQRSLSESAAT
CCCCCHHHCCHHHHH		33.4829255136
172PhosphorylationKLKQRSLSESAATRF
CCCHHHCCHHHHHHH		30.6529255136
174PhosphorylationKQRSLSESAATRFDV
CHHHCCHHHHHHHHC		21.5923403867
176UbiquitinationRSLSESAATRFDVGH
HHCCHHHHHHHHCCC		14.4829967540
177PhosphorylationSLSESAATRFDVGHE
HCCHHHHHHHHCCCH		31.4223403867
185PhosphorylationRFDVGHESINNPNPN
HHHCCCHHCCCCCCC		25.5828555341
195PhosphorylationNPNPNMLSKEEISKV
CCCCCCCCHHHHHHH		27.5325849741
196SumoylationPNPNMLSKEEISKVI
CCCCCCCHHHHHHHH		56.2428112733
196UbiquitinationPNPNMLSKEEISKVI
CCCCCCCHHHHHHHH		56.2429967540
200PhosphorylationMLSKEEISKVIHDDS
CCCHHHHHHHHCCCC		24.9327732954
202PhosphorylationSKEEISKVIHDDSVF
CHHHHHHHHCCCCCE		3.6232142685
284PhosphorylationMHDCVQLSTDKAGVV
HHHHHHCCCCCCCCE		19.9117525332
287UbiquitinationCVQLSTDKAGVVAEY
HHHCCCCCCCCEEEE		47.3229967540
309UbiquitinationSAVCPDDRRFFGLVT
EEECCCCCCEEEEEE		44.6922817900
314UbiquitinationDDRRFFGLVTMQTND
CCCCEEEEEEEEECC		2.1522817900
316UbiquitinationRRFFGLVTMQTNDDG
CCEEEEEEEEECCCC		14.4922817900
434UbiquitinationGNFHQEEKSNRVLVV
CCCCHHHCCCCEEEE		52.8829967540
435PhosphorylationNFHQEEKSNRVLVVD
CCCHHHCCCCEEEEE		32.90-
446PhosphorylationLVVDLGGSSSRHGPG
EEEECCCCCCCCCCC		24.2823403867
447PhosphorylationVVDLGGSSSRHGPGG
EEECCCCCCCCCCCC		34.3723403867
448PhosphorylationVDLGGSSSRHGPGGS
EECCCCCCCCCCCCC		29.9623403867
462UbiquitinationSAWDGVGGRGAQPWG
CCCCCCCCCCCCCCC		23.5722817900
467UbiquitinationVGGRGAQPWGAPWTG
CCCCCCCCCCCCCCC		30.8222817900
469UbiquitinationGRGAQPWGAPWTGPF
CCCCCCCCCCCCCCC		28.5722817900
474UbiquitinationPWGAPWTGPFCPDPE
CCCCCCCCCCCCCCC		14.9329967540
483PhosphorylationFCPDPEGSPPFEAAH
CCCCCCCCCCHHHHH		27.9527050516
492PhosphorylationPFEAAHQTDRFWDLN
CHHHHHCCCCCCCCC		21.1927732954
524MethylationSSVPPSKRGTVGAGC
CCCCCHHCCCCCCCC		50.8024129315
563UbiquitinationSYTDSTDGWSSINCG
CCCCCCCCCCCCCCC		26.6729967540
611PhosphorylationRKAFGMQSIFGPHRN
HHHHCCHHHHCCCCC		15.8228122231
633MethylationKKGSKFGRGTGLTQP
CCCCCCCCCCCCCCH		42.5016187615
635PhosphorylationGSKFGRGTGLTQPSQ
CCCCCCCCCCCCHHH		27.8830622161
638PhosphorylationFGRGTGLTQPSQRTS
CCCCCCCCCHHHHHH		39.5230622161
643MethylationGLTQPSQRTSARRSF
CCCCHHHHHHHHHHH		34.68115491215
649PhosphorylationQRTSARRSFGRSKRF
HHHHHHHHHCCCCCC		26.88-
657PhosphorylationFGRSKRFSITRSLDD
HCCCCCCEEECCHHH		27.3824719451
659PhosphorylationRSKRFSITRSLDDLE
CCCCCEEECCHHHHH		17.0129802988
661PhosphorylationKRFSITRSLDDLESA
CCCEEECCHHHHHHC		27.7426657352
667PhosphorylationRSLDDLESATVSDGE
CCHHHHHHCCCCCCC		36.2229255136
669PhosphorylationLDDLESATVSDGELT
HHHHHHCCCCCCCCC		29.8029255136
671PhosphorylationDLESATVSDGELTGA
HHHHCCCCCCCCCCC		35.2329255136
676PhosphorylationTVSDGELTGADLKDC
CCCCCCCCCCCHHHH		26.4829255136
685PhosphorylationADLKDCVSNNSLSSN
CCHHHHHHCCCCCCC		36.3027732954
688PhosphorylationKDCVSNNSLSSNASL
HHHHHCCCCCCCCCC		33.6027732954
690PhosphorylationCVSNNSLSSNASLPS
HHHCCCCCCCCCCCC		22.7427732954
691PhosphorylationVSNNSLSSNASLPSV
HHCCCCCCCCCCCCH		41.5327732954
694PhosphorylationNSLSSNASLPSVQSC
CCCCCCCCCCCHHHH		45.0927732954
697PhosphorylationSSNASLPSVQSCRRL
CCCCCCCCHHHHHHH		37.7727732954
700PhosphorylationASLPSVQSCRRLRER
CCCCCHHHHHHHHHH		13.8727732954
711PhosphorylationLRERRVASWAVSFER
HHHHHHHHHHHCHHH		16.8328122231
715PhosphorylationRVASWAVSFERLLQD
HHHHHHHCHHHHHCC		17.4028450419
771PhosphorylationYRAREIFSKFLCSKA
HHHHHHHHHHHHCCC		28.3224719451
776PhosphorylationIFSKFLCSKATTPVN
HHHHHHHCCCCCCCC		27.7224719451
777UbiquitinationFSKFLCSKATTPVNI
HHHHHHCCCCCCCCC		49.0729967540
779PhosphorylationKFLCSKATTPVNIDS
HHHHCCCCCCCCCCC		35.0624719451
824UbiquitinationDSYTRFLKSPLYQEC
CHHHHHHCCHHHHHH		47.5229967540
844PhosphorylationEGRALPDSQQVPSSP
CCCCCCCHHCCCCCC		22.1430266825
849PhosphorylationPDSQQVPSSPASKHS
CCHHCCCCCCHHHCC		50.5330266825
850PhosphorylationDSQQVPSSPASKHSL
CHHCCCCCCHHHCCC		20.5823401153
853PhosphorylationQVPSSPASKHSLGSD
CCCCCCHHHCCCCCC		33.9930266825
856PhosphorylationSSPASKHSLGSDHSS
CCCHHHCCCCCCCCC		37.8625849741
859PhosphorylationASKHSLGSDHSSVST
HHHCCCCCCCCCCCC		37.1327732954
862PhosphorylationHSLGSDHSSVSTPKK
CCCCCCCCCCCCCCC		37.1127732954
863PhosphorylationSLGSDHSSVSTPKKL
CCCCCCCCCCCCCCC		19.3727732954
865PhosphorylationGSDHSSVSTPKKLSG
CCCCCCCCCCCCCCC		40.7227732954
866PhosphorylationSDHSSVSTPKKLSGK
CCCCCCCCCCCCCCC		36.6527732954
871PhosphorylationVSTPKKLSGKSKSGR
CCCCCCCCCCCCCCC		53.7229391485
874PhosphorylationPKKLSGKSKSGRSLN
CCCCCCCCCCCCCHH		35.2628985074
876PhosphorylationKLSGKSKSGRSLNEE
CCCCCCCCCCCHHHH		46.6723403867
879PhosphorylationGKSKSGRSLNEELGD
CCCCCCCCHHHHHCC		38.7923927012
889PhosphorylationEELGDEDSEKKRKGA
HHHCCCCHHHHHCCC		49.6322817900
899PhosphorylationKRKGAFFSWSRTRST
HHCCCCEECCCCCCC		20.0723882029
901PhosphorylationKGAFFSWSRTRSTGR
CCCCEECCCCCCCCC		23.6823882029
903PhosphorylationAFFSWSRTRSTGRSQ
CCEECCCCCCCCCCH		24.3723882029
905PhosphorylationFSWSRTRSTGRSQKK
EECCCCCCCCCCHHH		34.3023882029
906PhosphorylationSWSRTRSTGRSQKKR
ECCCCCCCCCCHHHH		33.0723882029
909PhosphorylationRTRSTGRSQKKREHG
CCCCCCCCHHHHHHC		47.9323882029
934PhosphorylationGGLCRRESQGSVSSA
CCCCCCCCCCCCCCC		37.7217525332
937PhosphorylationCRRESQGSVSSAGSL
CCCCCCCCCCCCCCC		15.9323927012
939PhosphorylationRESQGSVSSAGSLDL
CCCCCCCCCCCCCCH		19.0322777824
940PhosphorylationESQGSVSSAGSLDLS
CCCCCCCCCCCCCHH		34.2017525332
943PhosphorylationGSVSSAGSLDLSEAC
CCCCCCCCCCHHHHH		20.5827732954
947PhosphorylationSAGSLDLSEACRTLA
CCCCCCHHHHHHHHC		23.8623927012
962AcetylationPEKDKATKHCCIHLP
CCCCCCCCEEEEECC		39.237673883
979AcetylationTSCVVAVKAGFSIKD
CEEEEEEECCCCHHH		32.817673895
1045PhosphorylationDLVPINRSVGLKAKP
EEEECCCCCCCCCCC		18.9528188228
1082UbiquitinationLVRLSGEKEPLDLGA
EEECCCCCCCCCCCC		69.0629967540
1110UbiquitinationEKDPSRGKASADKQK
ECCCCCCCCCCHHCC		37.7522817900
1115UbiquitinationRGKASADKQKGVPVK
CCCCCCHHCCCCCCC		54.3422817900
1117UbiquitinationKASADKQKGVPVKQN
CCCCHHCCCCCCCCC		68.5622817900
1122UbiquitinationKQKGVPVKQNTAVNS
HCCCCCCCCCCCCCC		31.5929967540
1148PhosphorylationRTLGKSNSIKIKGEN
CCCCCCCCEEEECCC		32.1424719451
1211UbiquitinationDQRGLLRKEDLVLPE
HHCCCCHHHHHCCHH		56.3929967540
1294PhosphorylationTTPPGQKSPSGPFCT
CCCCCCCCCCCCCCC		19.1927050516
1296PhosphorylationPPGQKSPSGPFCTPQ
CCCCCCCCCCCCCCC		67.2127732954
1301PhosphorylationSPSGPFCTPQSPVSL
CCCCCCCCCCCCCCH		25.4127732954
1304PhosphorylationGPFCTPQSPVSLAQE
CCCCCCCCCCCHHHH		28.5927732954
1307PhosphorylationCTPQSPVSLAQEGTA
CCCCCCCCHHHHCCH		22.7527732954
1321PhosphorylationAQIWKRQSQEVEAGG
HHHHHHHCCEEECCC		32.13-
1331PhosphorylationVEAGGIQTVEDEHVA
EECCCCCEECCCEEE		24.76-
1416PhosphorylationGPGRSQASGGPPTSD
CCCCCCCCCCCCCCC		36.3227251275
1421PhosphorylationQASGGPPTSDLPGLG
CCCCCCCCCCCCCCC		37.7027251275
1422PhosphorylationASGGPPTSDLPGLGP
CCCCCCCCCCCCCCC		42.8127251275
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RGS12_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RGS12_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RGS12_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GNAI1_HUMANGNAI1physical
11387333
GNAI2_HUMANGNAI2physical
11387333
GNAI3_HUMANGNAI3physical
11387333
EF1A1_MOUSEEef1a1physical
17124247
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RGS12_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-850, AND MASSSPECTROMETRY.
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-934 AND SER-940, ANDMASS SPECTROMETRY.
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-874 AND SER-889, ANDMASS SPECTROMETRY.
Ubiquitylation
ReferencePubMed
"Tryptic digestion of ubiquitin standards reveals an improved strategyfor identifying ubiquitinated proteins by mass spectrometry.";
Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.;
Proteomics 7:868-874(2007).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-1115, AND MASSSPECTROMETRY.

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