LRP3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRP3_HUMAN
• UniProt AC: O75074
• Protein Name: Low-density lipoprotein receptor-related protein 3
• Gene Name: LRP3
• Organism: Homo sapiens (Human).
• Sequence Length: 770
• Subcellular Localization: Membrane ; Single-pass type I membrane protein . Membrane, coated pit.
• Protein Description: Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro..
• Protein Sequence: MEKRAAAGLEGAPGARAQLAVVCLVNIFLTGRLSSAVPALAACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLDWLLLGPAAPPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGKLGQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLHCTWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLAAVPRKVITAALIGSLVCGLLLVIALGCAFKLYSLRTQEYRAFETQMTRLEAEFVRREAPPSYGQLIAQGLIPPVEDFPVYSASQASVLQNLRTAMRRQMRRHASRRGPSRRRLGRLWNRLFHRPRAPRGQIPLLTAARPSQTVLGDGFLQPAPGAAPDPPAPLMDTGSTRAAGDRPPSAPGRAPEVGPSGPPLPSGLRDPECRPVDKDRKVCREPLVDGPAPADAPREPCSAQDPHPQVSTASSTLGPHSPEPLGVCRNPPPPCSPMLEASDDEALLVC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	Phosphorylation	TERRGVIYSPAWPLN HHHCCCEECCCCCCC	13.24	-
66	Phosphorylation	SPAWPLNYPPGTNCS CCCCCCCCCCCCCEE	20.63	-
71	N-linked_Glycosylation	LNYPPGTNCSWYIQG CCCCCCCCEEEEEEE	24.60	UniProtKB CARBOHYD
75	Phosphorylation	PGTNCSWYIQGDRGD CCCCEEEEEEECCCC	2.73	-
85	Phosphorylation	GDRGDMITISFRNFD ECCCCEEEEEEECCC	12.16	23927012
87	Phosphorylation	RGDMITISFRNFDVE CCCEEEEEEECCCCC	14.98	29496963
199	N-linked_Glycosylation	GDGSDEGNCSAPASE CCCCCCCCCCCCCCC	17.96	UniProtKB CARBOHYD
359	N-linked_Glycosylation	RSAGHGFNATYQVKG HHCCCCCCEEEEEEC	35.65	UniProtKB CARBOHYD
524	Phosphorylation	GCAFKLYSLRTQEYR HHHHHHHHHHHHHHH	23.08	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LRP3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRP3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRP3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of LRP3_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.