MESD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MESD_HUMAN
• UniProt AC: Q14696
• Protein Name: LRP chaperone MESD {ECO:0000305}
• Gene Name: MESD {ECO:0000312|HGNC:HGNC:13520}
• Organism: Homo sapiens (Human).
• Sequence Length: 234
• Subcellular Localization: Endoplasmic reticulum . Released from apoptotic cells and shed photoreceptor outer segments.
• Protein Description: Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4 (By similarity). May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells (By similarity)..
• Protein Sequence: MAASRWARKAVVLLCASDLLLLLLLLPPPGSCAAEGSPGTPDESTPPPRKKKKDIRDYNDADMARLLEQWEKDDDIEEGDLPEHKRPSAPVDFSKIDPSKPESILKMTKKGKTLMMFVTVSGSPTEKETEEITSLWQGSLFNANYDVQRFIVGSDRAIFMLRDGSYAWEIKDFLVGQDRCADVTLEGQVYPGKGGGSKEKNKTKQDKGKKKKEGDLKSRSSKEENRAGNKREDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Ubiquitination	STPPPRKKKKDIRDY CCCCCCCCCCCCCCC	67.35	24816145
58	Phosphorylation	KKKDIRDYNDADMAR CCCCCCCCCHHHHHH	12.70	-
72	Ubiquitination	RLLEQWEKDDDIEEG HHHHHHHHCCCCCCC	64.60	29967540
85	Ubiquitination	EGDLPEHKRPSAPVD CCCCCCCCCCCCCCC	65.43	29967540
88	Phosphorylation	LPEHKRPSAPVDFSK CCCCCCCCCCCCHHH	49.60	25159151
88	O-linked_Glycosylation	LPEHKRPSAPVDFSK CCCCCCCCCCCCHHH	49.60	72259843
95	2-Hydroxyisobutyrylation	SAPVDFSKIDPSKPE CCCCCHHHCCCCCCH	51.64	-
95	Methylation	SAPVDFSKIDPSKPE CCCCCHHHCCCCCCH	51.64	115972971
103	Phosphorylation	IDPSKPESILKMTKK CCCCCCHHHHHHCCC	41.57	24719451
113	Phosphorylation	KMTKKGKTLMMFVTV HHCCCCCEEEEEEEE	28.67	-
121	Phosphorylation	LMMFVTVSGSPTEKE EEEEEEECCCCCHHH	24.96	21712546
123	Phosphorylation	MFVTVSGSPTEKETE EEEEECCCCCHHHHH	22.57	21712546
125	Phosphorylation	VTVSGSPTEKETEEI EEECCCCCHHHHHHH	62.48	-
179	Methylation	DFLVGQDRCADVTLE EEEECCCCCEEEEEE	15.05	115483151
201	N-linked_Glycosylation	GGGSKEKNKTKQDKG CCCCHHCCCCCCCCC	59.32	UniProtKB CARBOHYD
207	Ubiquitination	KNKTKQDKGKKKKEG CCCCCCCCCCCCCCC	70.86	-
209	Ubiquitination	KTKQDKGKKKKEGDL CCCCCCCCCCCCCCC	68.13	-
210	Ubiquitination	TKQDKGKKKKEGDLK CCCCCCCCCCCCCCC	77.17	-
211	Ubiquitination	KQDKGKKKKEGDLKS CCCCCCCCCCCCCCC	60.59	-
218	Phosphorylation	KKEGDLKSRSSKEEN CCCCCCCCCCCHHHH	44.70	26437602
220	Phosphorylation	EGDLKSRSSKEENRA CCCCCCCCCHHHHHH	53.50	26699800
221	Phosphorylation	GDLKSRSSKEENRAG CCCCCCCCHHHHHHC	42.87	26699800

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MESD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MESD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MESD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BRD4_HUMAN	BRD4	physical	21900206
RFC3_HUMAN	RFC3	physical	21900206
VATE1_HUMAN	ATP6V1E1	physical	21900206
PSA5_HUMAN	PSMA5	physical	21900206
SNX5_HUMAN	SNX5	physical	21900206
IMB1_HUMAN	KPNB1	physical	21900206
SNX7_HUMAN	SNX7	physical	21900206
A4_HUMAN	APP	physical	21832049
PDIA6_HUMAN	PDIA6	physical	26344197
KS6A4_HUMAN	RPS6KA4	physical	26344197
SYSC_HUMAN	SARS	physical	26344197
LAP2A_HUMAN	TMPO	physical	26344197
LAP2B_HUMAN	TMPO	physical	26344197

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.