ABCB5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ABCB5_MOUSE
• UniProt AC: B5X0E4
• Protein Name: ATP-binding cassette sub-family B member 5
• Gene Name: Abcb5
• Organism: Mus musculus (Mouse).
• Sequence Length: 1255
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair..
• Protein Sequence: MANSERTNGLQETNQRYGPLQEQVPKVGNQAVGPIEIFRFADNLDIVLMTLGILASMINGATVPLMSLVLGEISDHLINGCLVQTNRTKYQNCSQTQEKLNEDIIVLTLYYIGIGAAALIFGYVQISFWVITAARQTTRIRKQFFHSILAQDISWFDGSDICELNTRMTGDINKLCDGIGDKIPLMFQNISGFSIGLVISLIKSWKLSLVVLSTSPLIMASSALCSRMIISLTSKELDAYSKAGAVAEEALSSIQTVTAFGAQEKEIQRYTQHLKDAKDAGIKRATASKLSLGAVYFFMNGAYGLAFWYGTSLIFGGEPGYTIGTILAVFFSVIHSSYCIGSVAPHLETFTVARGAAFNIFQVIDKKPNIDNFSTAGFVPECIEGNIEFKNVSFSYPSRPSAKVLKGLNLKIKAGETVALVGPSGSGKSTTVQLLQRLYDPEDGCITVDENDIRAQNVRHYREQIGVVRQEPVLFGTTIGNNIKFGREGVGEKEMEQAAREANAYDFIMAFPKKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDTESESLVQTALEKASKGRTTIVVAHRLSTIRGADLIVTMKDGMVVEKGTHAELMAKQGLYYSLAMAQDIKKVDEQMESRTCSTAGNASYGSLCDVNSAKAPCTDQLEEAVHHQKTSLPEVSLLKIFKLSKSEWPFVVLGTLASALNGSVHPVFSIIFGKLVTMFEDKNKATLKQDAELYSMMLVVLGIVALVTYLMQGLFYGRAEENLAMRLRHSAFKAMLYQDMAWYDDKENNTGALTTTLAVDVAQIQGAATSRLGIVTQDVSNMSLSILISFIYGWEMTLLILSFAPVLAVTGMIQTAAMAGFANRDKQALKRAGKIATEAVENIRTVVSLTRERAFEQMYEETLQTQHRNALKRAHITGCCYAVSHAFVHFAHAAGFRFGAYLIQAGRMMPEGMFIVFTAIAYGAMAIGETLVWAPEYSKAKAGASHLFALLKNKPTINSCSQSGEKPDTCEGNLEFREVSFVYPCRPEVPVLQNMSLSIEKGKTVAFVGSSGCGKSTCVQLLQRFYDPMKGQVLLDGVDVKELNVQWLRSQTAIVSQEPVLFNCSIAENIAYGDNSRMVPLEEIKEVADAANIHSFIEGLPRKYNTLVGLRGVQLSGGQKQRLAIARALLRKPKILLLDEATSALDNESEKVVQQALDKARRGKTCLVVAHRLSTIQNADMIVVLQNGSIKEQGTHQELLRNGDTYFKLVAAH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
86	N-linked_Glycosylation	NGCLVQTNRTKYQNC HCCEEECCCCCCCCC		-
92	N-linked_Glycosylation	TNRTKYQNCSQTQEK CCCCCCCCCHHHHHH		-
189	N-linked_Glycosylation	KIPLMFQNISGFSIG HHHEEEECCCCCCHH		-
372	N-linked_Glycosylation	DKKPNIDNFSTAGFV CCCCCCCCCCCCCCC		-
391	N-linked_Glycosylation	EGNIEFKNVSFSYPS CCCEEEEEEEEECCC		-
431	Phosphorylation	SGSGKSTTVQLLQRL CCCCHHHHHHHHHHH		21183079
643	N-linked_Glycosylation	RTCSTAGNASYGSLC CCCCCCCCCCCCCCC		-
672	Phosphorylation	EAVHHQKTSLPEVSL HHHHHCCCCCCCHHH		108430743
673	Phosphorylation	AVHHQKTSLPEVSLL HHHHCCCCCCCHHHH		21454597
790	N-linked_Glycosylation	AWYDDKENNTGALTT CCCCCCCCCCCCEEE		-
1036	N-linked_Glycosylation	PEVPVLQNMSLSIEK CCCCEEEEEEEEECC		-
1105	N-linked_Glycosylation	SQEPVLFNCSIAENI CCCCEEEECEECCCC		-
1189	N-linked_Glycosylation	EATSALDNESEKVVQ CHHHCCCCCHHHHHH		-
1229	N-linked_Glycosylation	DMIVVLQNGSIKEQG CEEEEEECCCCCCCC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ABCB5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ABCB5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ABCB5_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ABCB5_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.