ASCL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASCL1_HUMAN
• UniProt AC: P50553
• Protein Name: Achaete-scute homolog 1 {ECO:0000303|PubMed:8390674}
• Gene Name: ASCL1 {ECO:0000312|HGNC:HGNC:738}
• Organism: Homo sapiens (Human).
• Sequence Length: 236
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation..
• Protein Sequence: MESSAKMESGGAGQQPQPQPQQPFLPPAACFFATAAAAAAAAAAAAAQSAQQQQQQQQQQQQAPQLRPAADGQPSGGGHKSAPKQVKRQRSSSPELMRCKRRLNFSGFGYSLPQQQPAAVARRNERERNRVKLVNLGFATLREHVPNGAANKKMSKVETLRSAVEYIRALQQLLDEHDAVSAAFQAGVLSPTISPNYSNDLNSMAGSPVSSYSSDEGSYDPLSPEEQELLDFTNWF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
91	Phosphorylation	KQVKRQRSSSPELMR HHHHHHHCCCHHHHH	27.16	26074081
92	Phosphorylation	QVKRQRSSSPELMRC HHHHHHCCCHHHHHH	52.69	26074081
93	Phosphorylation	VKRQRSSSPELMRCK HHHHHCCCHHHHHHH	24.52	26074081
111	Phosphorylation	NFSGFGYSLPQQQPA CCCCCCCCCCCCCCH	33.67	22912867
140	Phosphorylation	LVNLGFATLREHVPN EEEECHHHHHHHCCC	24.88	26699800
153	Methylation	PNGAANKKMSKVETL CCCHHHCCCCHHHHH	48.49	-
156	Acetylation	AANKKMSKVETLRSA HHHCCCCHHHHHHHH	40.36	-
159	Phosphorylation	KKMSKVETLRSAVEY CCCCHHHHHHHHHHH	30.38	27174698
162	Phosphorylation	SKVETLRSAVEYIRA CHHHHHHHHHHHHHH	39.52	27174698
166	Phosphorylation	TLRSAVEYIRALQQL HHHHHHHHHHHHHHH	6.79	27174698

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ASCL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ASCL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASCL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ITF2_HUMAN	TCF4	physical	10903890
MEF2A_HUMAN	MEF2A	physical	8662987
MEF2A_HUMAN	MEF2A	physical	8900141
MEF2C_HUMAN	MEF2C	physical	8900141
MEF2D_HUMAN	MEF2D	physical	8900141

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.