ACTY_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACTY_MOUSE
• UniProt AC: Q8R5C5
• Protein Name: Beta-centractin
• Gene Name: Actr1b
• Organism: Mus musculus (Mouse).
• Sequence Length: 376
• Subcellular Localization: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
• Protein Description: Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome (By similarity)..
• Protein Sequence: MESYDIIANQPVVIDNGSGVIKAGFAGDQIPKYCFPNYVGRPKHMRVMAGALEGDLFIGPKAEEHRGLLTIRYPMEHGVVRDWNDMERIWQYVYSKDQLQTFSEEHPVLLTEAPLNPSKNREKAAEVFFETFNVPALFISMQAVLSLYATGRTTGVVLDSGDGVTHAVPIYEGFAMPHSIMRVDIAGRDVSRYLRLLLRKEGADFHTSAEFEVVRTIKERACYLSINPQKDEALETEKVQYTLPDGSTLDVGPARFRAPELLFQPDLVGDESEGLHEVLAFAIHKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIKISAPQERLYSTWIGGSILASLDTFKKMWVSKKEYEEDGSRAIHRKTF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MESYDIIA -------CCCCCEEC	7.52	-
3	Phosphorylation	-----MESYDIIANQ -----CCCCCEECCC	27.14	25338131
4	Nitrated tyrosine	----MESYDIIANQP ----CCCCCEECCCC	9.61	-
4	Nitration	----MESYDIIANQP ----CCCCCEECCCC	9.61	16800626
4	Nitration	----MESYDIIANQP ----CCCCCEECCCC	9.61	16800626
32	Ubiquitination	FAGDQIPKYCFPNYV CCCCCCCCCCCCCCC	57.17	-
34	Glutathionylation	GDQIPKYCFPNYVGR CCCCCCCCCCCCCCC	5.96	24333276
45	Ubiquitination	YVGRPKHMRVMAGAL CCCCCHHHHHHHHHE	4.27	27667366
75	Ubiquitination	LLTIRYPMEHGVVRD CEEEECCCCCCCCCC	4.38	27667366
96	Ubiquitination	IWQYVYSKDQLQTFS HHHHHCCHHHHHCCC	31.63	-
119	Ubiquitination	EAPLNPSKNREKAAE ECCCCCCCCHHHHHH	62.37	22790023
171	Phosphorylation	VTHAVPIYEGFAMPH CEEEEEEECCCCCCC	12.15	82493
296	Phosphorylation	DLRRTLFSNIVLSGG HHHHHHHHCEEECCC	28.85	-
308	Ubiquitination	SGGSTLFKGFGDRLL CCCCHHHCCHHHHHH	57.34	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACTY_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACTY_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACTY_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CAZA1_HUMAN	CAPZA1	physical	26496610
CAZA2_HUMAN	CAPZA2	physical	26496610
CAPZB_HUMAN	CAPZB	physical	26496610
TCPZ_HUMAN	CCT6A	physical	26496610
DCTN1_HUMAN	DCTN1	physical	26496610
SVIL_HUMAN	SVIL	physical	26496610
TCPA_HUMAN	TCP1	physical	26496610
TCPG_HUMAN	CCT3	physical	26496610
1433F_HUMAN	YWHAH	physical	26496610
MTA1_HUMAN	MTA1	physical	26496610
ACTZ_HUMAN	ACTR1A	physical	26496610
DCTN2_HUMAN	DCTN2	physical	26496610
TCPD_HUMAN	CCT4	physical	26496610
TCPB_HUMAN	CCT2	physical	26496610
DCTN6_HUMAN	DCTN6	physical	26496610
TCPQ_HUMAN	CCT8	physical	26496610
DCTN3_HUMAN	DCTN3	physical	26496610
TCPE_HUMAN	CCT5	physical	26496610
DCTN4_HUMAN	DCTN4	physical	26496610
VEZA_HUMAN	VEZT	physical	26496610
PR40A_HUMAN	PRPF40A	physical	26496610
RPC2_HUMAN	POLR3B	physical	26496610
ARP10_HUMAN	ACTR10	physical	26496610
PDCL3_HUMAN	PDCL3	physical	26496610
OBSCN_HUMAN	OBSCN	physical	26496610
DCTN5_HUMAN	DCTN5	physical	26496610
SYNP2_HUMAN	SYNPO2	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Nitration

"Endogenously nitrated proteins in mouse brain: links toneurodegenerative disease.";
Sacksteder C.A., Qian W.-J., Knyushko T.V., Wang H., Chin M.H.,Lacan G., Melega W.P., Camp D.G. II, Smith R.D., Smith D.J.,Squier T.C., Bigelow D.J.;
Biochemistry 45:8009-8022(2006).
Cited for: NITRATION [LARGE SCALE ANALYSIS] AT TYR-4, AND MASS SPECTROMETRY.
PubMed: 16800626