MAMD1_HUMAN - dbPTM
MAMD1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MAMD1_HUMAN
UniProt AC Q13495
Protein Name Mastermind-like domain-containing protein 1
Gene Name MAMLD1
Organism Homo sapiens (Human).
Sequence Length 774
Subcellular Localization Nucleus . Punctate nuclear localization.
Protein Description Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ..
Protein Sequence MDDWKSRLVIKSMLPHFAMVGNRQEPRKLQESGKKPSWMEEEDLSFLYKSSPGRKHQGTVKRRQEEDHFQFPDMADGGYPNKIKRPCLEDVTLAMGPGAHPSTACAELQVPPLTINPSPAAMGVAGQSLLLENNPMNGNIMGSPFVVPQTTEVGLKGPTVPYYEKINSVPAVDQELQELLEELTKIQDPSPNELDLEKILGTKPEEPLVLDHPQATLSTTPKPSVQMSHLESLASSKEFASSCSQVTGMSLQIPSSSTGISYSIPSTSKQIVSPSSSMAQSKSQVQAMLPVALPPLPVPQWHHAHQLKALAASKQGSATKQQGPTPSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSCMSSNTLSGSTLRGSPNALLSSMTSSSNAALGPAMPYAPEKLPSPALTQQPQFGPQSSILANLMSSTIKTPQGHLMSALPASNPGPSPPYRPEKLSSPGLPQQSFTPQCSLIRSLTPTSNLLSQQQQQQQQQQQANVIFKPISSNSSKTLSMIMQQGMASSSPGATEPFTFGNTKPLSHFVSEPGPQKMPSMPTTSRQPSLLHYLQQPTPTQASSATASSTATATLQLQQQQQQQQQQPDHSSFLLQQMMQQPQRFQRSVASDSMPALPRQGCCHLFAWTSAASSVKPQHQHGNSFTSRQDPQPGDVSPSNITHVDKACKLGEARHPQVSLGRQPPSCQALGSESFLPGSSFAHELARVTSSYSTSEAAPWGSWDPKAWRQVPAPLLPSCDATARGTEIRSYGNDP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
55AcetylationYKSSPGRKHQGTVKR
HHCCCCCCCCCCCCC		46.3119827517
61AcetylationRKHQGTVKRRQEEDH
CCCCCCCCCCCCCCC		41.5219827523
162PhosphorylationLKGPTVPYYEKINSV
CCCCCCCHHHHHCCC		21.6625627689
163PhosphorylationKGPTVPYYEKINSVP
CCCCCCHHHHHCCCC		12.5025627689
165 (in isoform 3)Phosphorylation-30.9427251275
190PhosphorylationLTKIQDPSPNELDLE
HHCCCCCCCCCCCHH		48.9625159151
216PhosphorylationVLDHPQATLSTTPKP
CCCCCCCCCCCCCCC		18.9225627689
218PhosphorylationDHPQATLSTTPKPSV
CCCCCCCCCCCCCCC		26.3625627689
219PhosphorylationHPQATLSTTPKPSVQ
CCCCCCCCCCCCCCC		50.6725627689
220PhosphorylationPQATLSTTPKPSVQM
CCCCCCCCCCCCCCH		26.4125627689
247PhosphorylationASSCSQVTGMSLQIP
HHHHHHHHCCEEECC		21.3830576142
255PhosphorylationGMSLQIPSSSTGISY
CCEEECCCCCCCCCE		38.2530576142
261PhosphorylationPSSSTGISYSIPSTS
CCCCCCCCEECCCCC		17.7430576142
273PhosphorylationSTSKQIVSPSSSMAQ
CCCCCCCCCCCHHHC		22.2425159151
275PhosphorylationSKQIVSPSSSMAQSK
CCCCCCCCCHHHCCH		27.7826852163
276PhosphorylationKQIVSPSSSMAQSKS
CCCCCCCCHHHCCHH		27.7626852163
277O-linked_GlycosylationQIVSPSSSMAQSKSQ
CCCCCCCHHHCCHHH		23.6030059200
277PhosphorylationQIVSPSSSMAQSKSQ
CCCCCCCHHHCCHHH		23.6026852163
283PhosphorylationSSMAQSKSQVQAMLP
CHHHCCHHHHHHHCC		40.61-
364PhosphorylationPPPFSPQSLMVSCMS
CCCCCCHHHEEECCC		23.09-
383PhosphorylationSGSTLRGSPNALLSS
CCCCCCCCHHHHHHH		14.4627080861
412PhosphorylationYAPEKLPSPALTQQP
CCCCCCCCCHHHCCC		32.9928348404
439 (in isoform 3)Phosphorylation-32.9027251275
455PhosphorylationPASNPGPSPPYRPEK
CCCCCCCCCCCCHHH		44.4128348404
464PhosphorylationPYRPEKLSSPGLPQQ
CCCHHHCCCCCCCCC		45.6225159151
465PhosphorylationYRPEKLSSPGLPQQS
CCHHHCCCCCCCCCC		33.1622777824
512O-linked_GlycosylationVIFKPISSNSSKTLS
CEEEECCCCCHHHHH		41.2630059200
514O-linked_GlycosylationFKPISSNSSKTLSMI
EEECCCCCHHHHHHH		34.8530059200
515O-linked_GlycosylationKPISSNSSKTLSMIM
EECCCCCHHHHHHHH		33.6330059200
550O-linked_GlycosylationKPLSHFVSEPGPQKM
CCHHHCCCCCCCCCC		36.8130059200
564O-linked_GlycosylationMPSMPTTSRQPSLLH
CCCCCCCCCCCCHHH		31.2530059200
627O-linked_GlycosylationQPQRFQRSVASDSMP
CCHHHHHHHHHCCCC		15.9730059200
630PhosphorylationRFQRSVASDSMPALP
HHHHHHHHCCCCCCC		28.2321601212
658 (in isoform 3)Phosphorylation-30.0822210691
661 (in isoform 3)Phosphorylation-25.5524275569
676PhosphorylationDPQPGDVSPSNITHV
CCCCCCCCHHHCCCH		27.6130266825
678 (in isoform 3)Phosphorylation-33.1022210691
678PhosphorylationQPGDVSPSNITHVDK
CCCCCCHHHCCCHHH		33.1030266825
681PhosphorylationDVSPSNITHVDKACK
CCCHHHCCCHHHCCC		21.7930266825
685 (in isoform 3)Phosphorylation-55.3722210691
728O-linked_GlycosylationAHELARVTSSYSTSE
HHHHHHHHCCCCCCC		13.3530059200
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MAMD1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MAMD1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MAMD1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of MAMD1_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
300758Hypospadias 2, X-linked (HYSP2)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MAMD1_HUMAN

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Related Literatures of Post-Translational Modification

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