KLH20_HUMAN - dbPTM
KLH20_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KLH20_HUMAN
UniProt AC Q9Y2M5
Protein Name Kelch-like protein 20
Gene Name KLHL20
Organism Homo sapiens (Human).
Sequence Length 609
Subcellular Localization Cytoplasm, perinuclear region. Nucleus. Golgi apparatus, trans-Golgi network. Cell projection, axon. Cell projection, dendrite. Localizes in the perinuclear region in normal conditions. Following IFN-alpha or IFN-gamma treatment, it is relocalized an
Protein Description Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. [PubMed: 20389280 The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination]
Protein Sequence MEGKPMRRCTNIRPGETGMDVTSRCTLGDPNKLPEGVPQPARMPYISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRLGGGVGVIKMTHCESHIW
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10PhosphorylationGKPMRRCTNIRPGET
CCCCCCCCCCCCCCC		31.6928555341
45PhosphorylationPQPARMPYISDKHPR
CCCCCCCCCCCCCHH		12.0630206219
47PhosphorylationPARMPYISDKHPRQT
CCCCCCCCCCCHHHH		34.4630206219
76UbiquitinationDVVLVVGAKKIYAHR
CEEEEECCCCHHHHH		9.81-
199UbiquitinationFTQHNFQEVMESEEF
HHHCCHHHHHHCCCE		39.43-
263PhosphorylationHVRLPLLSPKFLVGT
HCCCCCCCCCEEEEE		33.4524719451
265UbiquitinationRLPLLSPKFLVGTVG
CCCCCCCCEEEEECC		48.2121906983
265UbiquitinationRLPLLSPKFLVGTVG
CCCCCCCCEEEEECC		48.2121890473
265UbiquitinationRLPLLSPKFLVGTVG
CCCCCCCCEEEEECC		48.2121890473
278UbiquitinationVGSDPLIKSDEECRD
CCCCCCCCCCHHHHH		60.5829967540
293PhosphorylationLVDEAKNYLLLPQER
HHHHHHHHEECCCCC		9.6824719451
308PhosphorylationPLMQGPRTRPRKPIR
CCCCCCCCCCCCCCC		48.4324719451
340UbiquitinationSSVERYDPQTNEWRM
HCCHHCCCCCCCCHH		33.6821890473
350PhosphorylationNEWRMVASMSKRRCG
CCCHHHHHHHCCCCC		16.5125101063
352PhosphorylationWRMVASMSKRRCGVG
CHHHHHHHCCCCCCC		22.1025101063
388UbiquitinationSVERYDPKTNQWSSD
CCEECCCCCCCCCCC		58.15-
510PhosphorylationAVYQDMIYAVGGRDD
EEECEEEEECCCCCC		6.65-
535PhosphorylationNPRTNQWSPVVAMTS
CCCCCCCCCEEEEEC		9.69-
541PhosphorylationWSPVVAMTSRRSGVG
CCCEEEEECCCCCCE		14.8920058876
542O-linked_GlycosylationSPVVAMTSRRSGVGL
CCEEEEECCCCCCEE		16.7730379171
542PhosphorylationSPVVAMTSRRSGVGL
CCEEEEECCCCCCEE		16.7720058876
584PhosphorylationDANTWRLYGGMNYRR
CCCEEEEECCEEECC		11.76-
589PhosphorylationRLYGGMNYRRLGGGV
EEECCEEECCCCCCE		6.55-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KLH20_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KLH20_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KLH20_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KLH20_HUMANKLHL20physical
14668487
ACTS_HUMANACTA1physical
14668487
DPYL1_HUMANCRMP1physical
16169070
PIN1_HUMANPIN1physical
16169070
ERG28_HUMANC14orf1physical
16169070
GBP2_HUMANGBP2physical
16169070
CE126_HUMANKIAA1377physical
16169070
LC7L2_HUMANLUC7L2physical
16169070
LRIF1_HUMANLRIF1physical
16169070
DAPK1_HUMANDAPK1physical
20389280
CUL3_HUMANCUL3physical
20389280
PML_HUMANPMLphysical
20389280
EPAS1_HUMANEPAS1physical
21888897
PML_HUMANPMLphysical
21840486
ANM6_HUMANPRMT6physical
23455924
SUV91_HUMANSUV39H1physical
23455924
CORO7_HUMANCORO7physical
24768539
ARHGC_HUMANARHGEF12physical
21670212
FCG3B_HUMANFCGR3Bphysical
26186194
SATB2_HUMANSATB2physical
26186194
NUFP2_HUMANNUFIP2physical
26186194
MA7D2_HUMANMAP7D2physical
26186194
UBP27_HUMANUSP27Xphysical
26186194
SPAG7_HUMANSPAG7physical
26186194
IF2B_HUMANEIF2S2physical
26186194
PRI2_HUMANPRIM2physical
26186194
HDGR2_HUMANHDGFRP2physical
26186194
MIO_HUMANMIOSphysical
26186194
SYNC_HUMANNARSphysical
26186194
ATX2L_HUMANATXN2Lphysical
26186194
FXL17_HUMANFBXL17physical
26186194
NUDC3_HUMANNUDCD3physical
26186194
CTU2_HUMANCTU2physical
26186194
PDIP3_HUMANPOLDIP3physical
26186194
NEUG_HUMANNRGNphysical
26186194
PUR8_HUMANADSLphysical
26186194
IPP_HUMANIPPphysical
26186194
CNO10_HUMANCNOT10physical
26186194
CKAP5_HUMANCKAP5physical
26186194
PIR_HUMANPIRphysical
26186194
KLH26_HUMANKLHL26physical
26186194
OSB11_HUMANOSBPL11physical
26186194
TRI33_HUMANTRIM33physical
26186194
PIMT_HUMANPCMT1physical
26186194
RHOA_HUMANRHOAphysical
26186194
HIF1N_HUMANHIF1ANphysical
26186194
TCEA1_HUMANTCEA1physical
26186194
UBAP2_HUMANUBAP2physical
26186194
PRI1_HUMANPRIM1physical
26186194
PICAL_HUMANPICALMphysical
26186194
ALR_HUMANGFERphysical
26186194
RBM12_HUMANRBM12physical
26186194
KRBA1_HUMANKRBA1physical
26186194
CORO7_HUMANCORO7physical
26186194
NS1BP_HUMANIVNS1ABPphysical
25619834
PML_HUMANPMLphysical
25619834
DAPK1_HUMANDAPK1physical
25619834
CUL3_HUMANCUL3physical
25619834
PML_HUMANPMLphysical
24487962
SATB2_HUMANSATB2physical
28514442
KLH22_HUMANKLHL22physical
28514442
FXL17_HUMANFBXL17physical
28514442
FCG3B_HUMANFCGR3Bphysical
28514442
CUL3_HUMANCUL3physical
28514442
NEUG_HUMANNRGNphysical
28514442
IPP_HUMANIPPphysical
28514442
SPAG7_HUMANSPAG7physical
28514442
KLH26_HUMANKLHL26physical
28514442
CORO7_HUMANCORO7physical
28514442
PIR_HUMANPIRphysical
28514442
PRI2_HUMANPRIM2physical
28514442
MA7D2_HUMANMAP7D2physical
28514442
SYNC_HUMANNARSphysical
28514442
KRBA1_HUMANKRBA1physical
28514442
TRI33_HUMANTRIM33physical
28514442
TCEA1_HUMANTCEA1physical
28514442
PUR8_HUMANADSLphysical
28514442
HDGR2_HUMANHDGFRP2physical
28514442
ALR_HUMANGFERphysical
28514442
CGL_HUMANCTHphysical
28514442
PDIP3_HUMANPOLDIP3physical
28514442
NUDC3_HUMANNUDCD3physical
28514442
PIMT_HUMANPCMT1physical
28514442
RPR1B_HUMANRPRD1Bphysical
28514442
RBM12_HUMANRBM12physical
28514442
CTU2_HUMANCTU2physical
28514442
PRI1_HUMANPRIM1physical
28514442
MIO_HUMANMIOSphysical
28514442
RHOA_HUMANRHOAphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KLH20_HUMAN

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Related Literatures of Post-Translational Modification

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