FCG3B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FCG3B_HUMAN
• UniProt AC: O75015
• Protein Name: Low affinity immunoglobulin gamma Fc region receptor III-B
• Gene Name: FCGR3B
• Organism: Homo sapiens (Human).
• Sequence Length: 233
• Subcellular Localization: Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Secreted after cleavage.
• Protein Description: Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils..
• Protein Sequence: MWQLLLPTALLLLVSAGMRTEDLPKAVVFLEPQWYSVLEKDSVTLKCQGAYSPEDNSTQWFHNESLISSQASSYFIDAATVNDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVFKEEDPIHLRCHSWKNTALHKVTYLQNGKDRKYFHHNSDFHIPKATLKDSGSYFCRGLVGSKNVSSETVNITITQGLAVSTISSFSPPGYQVSFCLVMVLLFAVDTGLYFSVKTNI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MWQLLLPTALLLLVS CHHHHHHHHHHHHHH	29.88	24043423
15	Phosphorylation	TALLLLVSAGMRTED HHHHHHHHCCCCCCC	21.05	24043423
56	N-linked_Glycosylation	GAYSPEDNSTQWFHN CCCCCCCCCCCEECC	45.34	UniProtKB CARBOHYD
63	N-linked_Glycosylation	NSTQWFHNESLISSQ CCCCEECCHHHHHHH	30.95	UniProtKB CARBOHYD
82	N-linked_Glycosylation	FIDAATVNDSGEYRC EEEEEEECCCCCEEE	33.12	UniProtKB CARBOHYD
92	N-linked_Glycosylation	GEYRCQTNLSTLSDP CCEEEECCCCCCCCC	13.20	UniProtKB CARBOHYD
163	Phosphorylation	DFHIPKATLKDSGSY CCCCCCCCCCCCCCE	40.23	-
167	Phosphorylation	PKATLKDSGSYFCRG CCCCCCCCCCEECEE	28.22	-
169	Phosphorylation	ATLKDSGSYFCRGLV CCCCCCCCEECEEEC	20.98	-
170	Phosphorylation	TLKDSGSYFCRGLVG CCCCCCCEECEEECC	15.38	-
180	N-linked_Glycosylation	RGLVGSKNVSSETVN EEECCCCCCCCCEEE	40.37	UniProtKB CARBOHYD
187	N-linked_Glycosylation	NVSSETVNITITQGL CCCCCEEEEEEECCE	32.86	UniProtKB CARBOHYD
198	Phosphorylation	TQGLAVSTISSFSPP ECCEEEEEEHHCCCC	20.48	25332170
200	GPI-anchor	GLAVSTISSFSPPGY CEEEEEEHHCCCCCH	25.97	-
200	Phosphorylation	GLAVSTISSFSPPGY CEEEEEEHHCCCCCH	25.97	25332170
207	Phosphorylation	SSFSPPGYQVSFCLV HHCCCCCHHHHHHHH	16.12	25332170

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FCG3B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FCG3B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FCG3B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GLPK_HUMAN	GK	physical	26186194
NRP2_HUMAN	NRP2	physical	26186194
COT2_HUMAN	NR2F2	physical	26186194
COX16_HUMAN	COX16	physical	26186194
AT12A_HUMAN	ATP12A	physical	26186194
CD109_HUMAN	CD109	physical	26186194
NPTX1_HUMAN	NPTX1	physical	26186194
OAF_HUMAN	OAF	physical	26186194
TBA1A_HUMAN	TUBA1A	physical	26186194
TBB3_HUMAN	TUBB3	physical	26186194
TBB8_HUMAN	TUBB8	physical	26186194
WDR34_HUMAN	WDR34	physical	26186194
CNOT8_HUMAN	CNOT8	physical	26186194
LRC8C_HUMAN	LRRC8C	physical	26186194
LRC8E_HUMAN	LRRC8E	physical	26186194
LRC8C_HUMAN	LRRC8C	physical	28514442
ICK_HUMAN	ICK	physical	28514442
LRC8E_HUMAN	LRRC8E	physical	28514442
NPTX1_HUMAN	NPTX1	physical	28514442
TBB3_HUMAN	TUBB3	physical	28514442
TBB8_HUMAN	TUBB8	physical	28514442
NRP2_HUMAN	NRP2	physical	28514442
COX16_HUMAN	COX16	physical	28514442
AT12A_HUMAN	ATP12A	physical	28514442
ITAV_HUMAN	ITGAV	physical	28514442
COT2_HUMAN	NR2F2	physical	28514442
CD109_HUMAN	CD109	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.