dbPTM

COX16_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	COX16_HUMAN
UniProt AC	Q9P0S2
Protein Name	Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial {ECO:0000305}
Gene Name	COX16 {ECO:0000303\|PubMed:29355485, ECO:0000303\|PubMed:29381136, ECO:0000312\|HGNC:HGNC:20213}
Organism	Homo sapiens (Human).
Sequence Length	106
Subcellular Localization	Mitochondrion inner membrane Single-pass membrane protein .
Protein Description	Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. [PubMed: 29355485]
Protein Sequence	MFAPAVMRAFRKNKTLGYGVPMLLLIVGGSFGLREFSQIRYDAVKSKMDPELEKKLKENKISLESEYEKIKDSKFDDWKNIRGPRPWEDPDLLQGRNPESLKTKTT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Acetylation	AVMRAFRKNKTLGYG HHHHHHHHCCCCCCC	57.24	7932693
41	Phosphorylation	REFSQIRYDAVKSKM HHHHHHHHHHHHHHC	15.19	-
45	Ubiquitination	QIRYDAVKSKMDPEL HHHHHHHHHHCCHHH	46.19	29967540
65	Phosphorylation	ENKISLESEYEKIKD HCCCCHHHHHHHHHC	51.26	28796482
67	Phosphorylation	KISLESEYEKIKDSK CCCHHHHHHHHHCCC	31.62	28796482
69	Ubiquitination	SLESEYEKIKDSKFD CHHHHHHHHHCCCCC	54.90	29967540
74	Acetylation	YEKIKDSKFDDWKNI HHHHHCCCCCCCCCC	64.05	7972735
79	Acetylation	DSKFDDWKNIRGPRP CCCCCCCCCCCCCCC	49.87	7972745

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of COX16_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of COX16_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of COX16_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of COX16_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of COX16_HUMAN

Related Literatures of Post-Translational Modification