NRP2_HUMAN - dbPTM
NRP2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NRP2_HUMAN
UniProt AC O60462
Protein Name Neuropilin-2
Gene Name NRP2
Organism Homo sapiens (Human).
Sequence Length 931
Subcellular Localization Membrane
Single-pass type I membrane protein .
Isoform s9: Secreted .
Protein Description High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF..
Protein Sequence MDMFPLTWVFLALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLVHQEPLENFQCNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLHGDDNGWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHKVFQANNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIADSQISASSTQEYLWSPSAARLVSSRSGWFPRIPQAQPGEEWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTPDIRRFDPIPAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPTVETLGPTVKSEETTTPYPTEEEATECGENCSFEDDKDLQLPSGFNCNFDFLEEPCGWMYDHAKWLRTTWASSSSPNDRTFPDDRNFLRLQSDSQREGQYARLISPPVHLPRSPVCMEFQYQATGGRGVALQVVREASQESKLLWVIREDQGGEWKHGRIILPSYDMEYQIVFEGVIGKGRSGEIAIDDIRISTDVPLENCMEPISAFAGENFKVDIPEIHEREGYEDEIDDEYEVDWSNSSSATSGSGAPSTDKEKSWLYTLDPILITIIAMSSLGVLLGATCAGLLLYCTCSYSGLSSRSCTTLENYNFELYDGLKHKVKMNHQKCCSEA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
112PhosphorylationCGNIAPPTIISSGSM
CCCCCCCEEECCCCE		29.8624719451
112PhosphorylationCGNIAPPTIISSGSM
CCCCCCCEEECCCCE		29.8624719451
112PhosphorylationCGNIAPPTIISSGSM
CCCCCCCEEECCCCE		29.8624719451
112PhosphorylationCGNIAPPTIISSGSM
CCCCCCCEEECCCCE		29.8624719451
136PhosphorylationARQGAGFSLRYEIFK
HHCCCCEEEEEEEEE		15.8324719451
152N-linked_GlycosylationGSEDCSKNFTSPNGT
CCCCHHCCCCCCCCC		29.1817989695
157N-linked_GlycosylationSKNFTSPNGTIESPG
HCCCCCCCCCCCCCC		61.0717989695
319PhosphorylationHGDDNGWTPNLDSNK
CCCCCCCCCCCCCCC		12.0524275569
324PhosphorylationGWTPNLDSNKEYLQV
CCCCCCCCCCHHHHH		53.6324275569
340PhosphorylationLRFLTMLTAIATQGA
HHHHHHHHHHHHCCC		12.7524275569
349PhosphorylationIATQGAISRETQNGY
HHHCCCCCCCCCCCE		24.4324275569
469PhosphorylationPSAARLVSSRSGWFP
HHHHHHHHCCCCCCC		25.3224719451
472PhosphorylationARLVSSRSGWFPRIP
HHHHHCCCCCCCCCC		42.1824719451
494PhosphorylationWLQVDLGTPKTVKGV
EEEEECCCCCCEEEE		28.9824719451
507MethylationGVIIQGARGGDSITA
EEEEECCCCCCCEEH		57.35115485559
595O-linked_GlycosylationEVLGCDWTDSKPTVE
EEECCCCCCCCCCEE		19.6955835371
600O-linked_GlycosylationDWTDSKPTVETLGPT
CCCCCCCCEECCCCC		34.4155835373
603O-linked_GlycosylationDSKPTVETLGPTVKS
CCCCCEECCCCCCCC		32.4555835375
607O-linked_GlycosylationTVETLGPTVKSEETT
CEECCCCCCCCCCCC		38.4755835377
629N-linked_GlycosylationEATECGENCSFEDDK
HHCCCCCCCCCCCCC		16.41UniProtKB CARBOHYD
672O-linked_GlycosylationLRTTWASSSSPNDRT
HHHHCCCCCCCCCCC		27.3955826451
781PhosphorylationGVIGKGRSGEIAIDD
CCCCCCCCCCEEEEE		49.8223312004
839N-linked_GlycosylationEYEVDWSNSSSATSG
CEEECCCCCCCCCCC		41.47UniProtKB CARBOHYD
866PhosphorylationLYTLDPILITIIAMS
HHCCHHHHHHHHHHH		3.2526657352
866 (in isoform 4)Phosphorylation-3.2526657352
869 (in isoform 4)Phosphorylation-1.1826657352
869PhosphorylationLDPILITIIAMSSLG
CHHHHHHHHHHHHHH		1.1826657352
871 (in isoform 5)Phosphorylation-6.4826657352
874 (in isoform 5)Phosphorylation-18.9626657352
874PhosphorylationITIIAMSSLGVLLGA
HHHHHHHHHHHHHHH		18.9627251275
875PhosphorylationTIIAMSSLGVLLGAT
HHHHHHHHHHHHHHH		4.28-
875PhosphorylationTIIAMSSLGVLLGAT
HHHHHHHHHHHHHHH		4.2825884760
875 (in isoform 4)Phosphorylation-4.2825884760
877PhosphorylationIAMSSLGVLLGATCA
HHHHHHHHHHHHHHH		4.9025884760
877PhosphorylationIAMSSLGVLLGATCA
HHHHHHHHHHHHHHH		4.90-
877 (in isoform 4)Phosphorylation-4.9025884760
880 (in isoform 5)Phosphorylation-18.0625884760
882 (in isoform 5)Phosphorylation-10.9025884760
899 (in isoform 4)Phosphorylation-33.0029514088
899PhosphorylationCSYSGLSSRSCTTLE
CCCCCCCCCCCCEEE		33.0029514088
901PhosphorylationYSGLSSRSCTTLENY
CCCCCCCCCCEEECC		20.1227732954
903PhosphorylationGLSSRSCTTLENYNF
CCCCCCCCEEECCCE		35.3427732954
904PhosphorylationLSSRSCTTLENYNFE
CCCCCCCEEECCCEE		36.0827732954
904 (in isoform 5)Phosphorylation-36.0829514088
908PhosphorylationSCTTLENYNFELYDG
CCCEEECCCEEECCC		16.3227732954
913PhosphorylationENYNFELYDGLKHKV
ECCCEEECCCHHHHC		10.7727642862
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NRP2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NRP2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NRP2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TGFR2_HUMANTGFBR2physical
21186301
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NRP2_HUMAN

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Related Literatures of Post-Translational Modification

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