IPP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IPP_HUMAN
• UniProt AC: Q9Y573
• Protein Name: Actin-binding protein IPP
• Gene Name: IPP
• Organism: Homo sapiens (Human).
• Sequence Length: 584
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: May play a role in organizing the actin cytoskeleton..
• Protein Sequence: MANEDCPKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Ubiquitination	MANEDCPKAADSPFS CCCCCCCCCCCCCCC	63.64	-
47	Phosphorylation	QLQVGQESFKAHRLV EEEECCHHHHHHHHH	24.94	26546556
185	Ubiquitination	LTKDQLIKILRSEEL ECHHHHHHHHHCCCC	44.26	21906983
217	Ubiquitination	KDLGKRRKHVVEVLD HHHHHCCCHHHHCCC	44.80	-
238	Ubiquitination	LPPQRLLKYIEGVSD CCHHHHHHHHHCCCC	49.09	21906983
238	Ubiquitination	LPPQRLLKYIEGVSD CCHHHHHHHHHCCCC	49.09	21890473
238	Ubiquitination	LPPQRLLKYIEGVSD CCHHHHHHHHHCCCC	49.09	21890473
239	Phosphorylation	PPQRLLKYIEGVSDF CHHHHHHHHHCCCCH	12.27	-
257	Ubiquitination	VALQTLLKEYCEVCK HHHHHHHHHHHHHCC	50.15	-
259	Phosphorylation	LQTLLKEYCEVCKSP HHHHHHHHHHHCCCC	7.72	27794612
264	Ubiquitination	KEYCEVCKSPKENKF HHHHHHCCCCCCCCC	74.99	27667366
265	Phosphorylation	EYCEVCKSPKENKFC HHHHHCCCCCCCCCC	35.76	23312004
270	Ubiquitination	CKSPKENKFCSFLQT CCCCCCCCCCCHHHC	49.17	-
279	Ubiquitination	CSFLQTSKVRPRKKA CCHHHCCCCCCCHHH	45.72	29967540
288	Ubiquitination	RPRKKARKYLYAVGG CCCHHHHHHHHHCCC	44.46	-
289	Phosphorylation	PRKKARKYLYAVGGY CCHHHHHHHHHCCCC	10.21	-
291	Phosphorylation	KKARKYLYAVGGYTR HHHHHHHHHCCCCEE	8.99	-
296	Phosphorylation	YLYAVGGYTRLQGGR HHHHCCCCEEECCCC	5.24	-
305	Phosphorylation	RLQGGRWSDSRALSC EECCCCCCCCCHHHH	25.09	20873877
307	Phosphorylation	QGGRWSDSRALSCVE CCCCCCCCCHHHHHH	17.59	20873877
311	Phosphorylation	WSDSRALSCVERFDT CCCCCHHHHHHHCCC	18.35	20873877
334	Phosphorylation	SSLHQARSGLGVTVL HHHHHHHCCCCEEEE	41.19	-
463	Ubiquitination	EVYDPLSKRWSPLPP EEECCCCCCCCCCCC	66.62	21906983
520	Ubiquitination	WVEVASMKVPRAGMC EEEEEECCCCCCCCE	46.74	21890473
542 (in isoform 2)	Phosphorylation	-	39.19	22210691
543 (in isoform 2)	Phosphorylation	-	30.26	22210691
544 (in isoform 2)	Phosphorylation	-	28.46	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IPP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IPP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IPP_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of IPP_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.