FXL17_HUMAN - dbPTM
FXL17_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FXL17_HUMAN
UniProt AC Q9UF56
Protein Name F-box/LRR-repeat protein 17
Gene Name FBXL17
Organism Homo sapiens (Human).
Sequence Length 701
Subcellular Localization
Protein Description Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex..
Protein Sequence MGHLLSKEPRNRPSQKRPRCCSWCRRRRPLLRLPRRTPAKVPPQPAAPRSRDCFFRGPCMLCFIVHSPGAPAPAGPEEEPPLSPPPRDGAYAAASSSQHLARRYAALAAEDCAAAARRFLLSSAAAAAAAAASASSPASCCKELGLAAAAAWEQQGRSLFLASLGPVRFLGPPAAVQLFRGPTPSPAELPTPPEMVCKRKGAGVPACTPCKQPRCGGGGCGGGGGGGGGGGPAGGGASPPRPPDAGCCQAPEQPPQPLCPPPSSPTSEGAPTEAGGDAVRAGGTAPLSAQQQHECGDADCRESPENPCDCHREPPPETPDINQLPPSILLKIFSNLSLDERCLSASLVCKYWRDLCLDFQFWKQLDLSSRQQVTDELLEKIASRSQNIIEINISDCRSMSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSCKITDYALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNEVTVEQLVQQYPHITFSTVLQDCKRTLERAYQMGWTPNMSAASS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
83PhosphorylationPEEEPPLSPPPRDGA
CCCCCCCCCCCCCCC		40.9326329039
89 (in isoform 3)Ubiquitination-23.0521906983
89 (in isoform 2)Ubiquitination-23.0521906983
91PhosphorylationPPPRDGAYAAASSSQ
CCCCCCCCHHHHCHH		11.4227642862
95PhosphorylationDGAYAAASSSQHLAR
CCCCHHHHCHHHHHH		26.2927642862
104PhosphorylationSQHLARRYAALAAED
HHHHHHHHHHHHHHH		7.2329978859
139PhosphorylationASASSPASCCKELGL
HHCCCHHHHHHHHHH		24.35-
183PhosphorylationVQLFRGPTPSPAELP
HHHHCCCCCCCCCCC		38.94-
208PhosphorylationGAGVPACTPCKQPRC
CCCCCCCCCCCCCCC		33.5528985074
211AcetylationVPACTPCKQPRCGGG
CCCCCCCCCCCCCCC		65.6225953088
266PhosphorylationCPPPSSPTSEGAPTE
CCCCCCCCCCCCCCC		41.1622468782
267PhosphorylationPPPSSPTSEGAPTEA
CCCCCCCCCCCCCCC		37.1022468782
288PhosphorylationAGGTAPLSAQQQHEC
CCCCCCCCHHHHHHC		23.9928985074
303PhosphorylationGDADCRESPENPCDC
CCCCCCCCCCCCCCC		20.4028348404
337PhosphorylationLKIFSNLSLDERCLS
HHHHCCCCCCHHHHH		37.7221815630
374PhosphorylationLSSRQQVTDELLEKI
CCCCHHHHHHHHHHH		21.3030622161
380UbiquitinationVTDELLEKIASRSQN
HHHHHHHHHHHCCCC		43.4729967540
383PhosphorylationELLEKIASRSQNIIE
HHHHHHHHCCCCEEE		35.62-
429PhosphorylationCKQLSDTSIIAVASH
CCCCCCCCEEEHHHC		19.58-
450UbiquitinationVHVGNQDKLTDEGLK
ECCCCHHHCCHHHHH		43.4529967540
457UbiquitinationKLTDEGLKQLGSKCR
HCCHHHHHHHHHHHH		55.0929967540
461PhosphorylationEGLKQLGSKCRELKD
HHHHHHHHHHHHCCC		36.86-
467UbiquitinationGSKCRELKDIHFGQC
HHHHHHCCCCCCCEE		50.3029967540
487UbiquitinationEGMIVIAKGCLKLQR
CCCEEEEEHHHHHHH		38.752190698
487 (in isoform 1)Ubiquitination-38.7521906983
501UbiquitinationRIYMQENKLVTDQSV
HHHHHCCCCCCHHHH		43.5129967540
557PhosphorylationITELDNETVMEIVKR
CEECCHHHHHHHHHH		31.26-
595UbiquitinationAKEGQNLKELYLVSC
HHCCCCHHHEEEEEC		53.9029967540
643UbiquitinationTLIAQSSKSLRYLGL
EEEEECCCCHHHHCC		59.7729967540
688PhosphorylationKRTLERAYQMGWTPN
HHHHHHHHHCCCCCC		12.78-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FXL17_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FXL17_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FXL17_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ZBT18_HUMANZBTB18physical
24035498
SUFU_HUMANSUFUphysical
24035498
ZBT10_HUMANZBTB10physical
24035498
BACH1_HUMANBACH1physical
24035498
SKP1_HUMANSKP1physical
24035498
CUL1_HUMANCUL1physical
24035498
SKP1_HUMANSKP1physical
27234298
CUL1_HUMANCUL1physical
27234298
SUFU_HUMANSUFUphysical
27234298
ZBT10_HUMANZBTB10physical
27234298
K1671_HUMANKIAA1671physical
27234298
KAISO_HUMANZBTB33physical
27234298
BACH1_HUMANBACH1physical
27234298
M3K7_HUMANMAP3K7physical
27234298
PJA2_HUMANPJA2physical
27234298
NOTC2_HUMANNOTCH2physical
27234298
STK31_HUMANSTK31physical
27234298
DVL2_HUMANDVL2physical
27234298
PPM1G_HUMANPPM1Gphysical
27234298
GLI1_HUMANGLI1physical
27234298
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FXL17_HUMAN

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Related Literatures of Post-Translational Modification

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