ZBT18_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZBT18_HUMAN
• UniProt AC: Q99592
• Protein Name: Zinc finger and BTB domain-containing protein 18
• Gene Name: ZBTB18
• Organism: Homo sapiens (Human).
• Sequence Length: 522
• Subcellular Localization: Nucleus. Associates with condensed chromatin.
• Protein Description: Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus..
• Protein Sequence: MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKRDIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEKATTEADSTKKEEDASSCSDKVESLSDGSSHIAGDLPSDEDEGEDEKLNILPSKRDLAAEPGNMWMRLPSDSAGIPQAGGEAEPHATAAGKTVASPCSSTESLSQRSVTSVRDSADVDCVLDLSVKSSLSGVENLNSSYFSSQDVLRSNLVQVKVEKEASCDESDVGTNDYDMEHSTVKESVSTNNRVQYEPAHLAPLREDSVLRELDREDKASDDEMMTPESERVQVEGGMESSLLPYVSNILSPAGQIFMCPLCNKVFPSPHILQIHLSTHFREQDGIRSKPAADVNVPTCSLCGKTFSCMYTLKRHERTHSGEKPYTCTQCGKSFQYSHNLSRHAVVHTREKPHACKWCERRFTQSGDLYRHIRKFHCELVNSLSVKSEALSLPTVRDWTLEDSSQELWK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
123	Phosphorylation	KLKEKATTEADSTKK HHHHHCCCCCCCCCH		30576142
127	Phosphorylation	KATTEADSTKKEEDA HCCCCCCCCCHHHHH		30576142
128	Phosphorylation	ATTEADSTKKEEDAS CCCCCCCCCHHHHHH		28258704
136	Phosphorylation	KKEEDASSCSDKVES CHHHHHHHCHHHHHH		-
157	Phosphorylation	HIAGDLPSDEDEGED CCCCCCCCCCCCCCH		22496350
166	Phosphorylation	EDEGEDEKLNILPSK CCCCCHHHCCCCCCH		27251275
172	Phosphorylation	EKLNILPSKRDLAAE HHCCCCCCHHHCCCC		24719451
189	Phosphorylation	NMWMRLPSDSAGIPQ CEEEECCCCCCCCCC		29978859
191	Phosphorylation	WMRLPSDSAGIPQAG EEECCCCCCCCCCCC		29978859
198	Phosphorylation	SAGIPQAGGEAEPHA CCCCCCCCCCCCCCC		27251275
211	Phosphorylation	HATAAGKTVASPCSS CCCCCCCEEECCCCC		27732954
214	Phosphorylation	AAGKTVASPCSSTES CCCCEEECCCCCCHH		27732954
217	Phosphorylation	KTVASPCSSTESLSQ CEEECCCCCCHHHHH		27732954
218	Phosphorylation	TVASPCSSTESLSQR EEECCCCCCHHHHHC		27732954
219	Phosphorylation	VASPCSSTESLSQRS EECCCCCCHHHHHCC		27732954
221	Phosphorylation	SPCSSTESLSQRSVT CCCCCCHHHHHCCCC		27732954
223	Phosphorylation	CSSTESLSQRSVTSV CCCCHHHHHCCCCCH		27732954
246	Phosphorylation	VLDLSVKSSLSGVEN EEEEEECHHHCCCCC		28634120
247	Phosphorylation	LDLSVKSSLSGVENL EEEEECHHHCCCCCC		28634120
249	Phosphorylation	LSVKSSLSGVENLNS EEECHHHCCCCCCCC		28634120
256	Phosphorylation	SGVENLNSSYFSSQD CCCCCCCCCCCCCHH		28634120
260	Phosphorylation	NLNSSYFSSQDVLRS CCCCCCCCCHHHHHH		28634120
273	Sumoylation	RSNLVQVKVEKEASC HHCCEEEEEEECCCC		28112733
279	Phosphorylation	VKVEKEASCDESDVG EEEEECCCCCHHCCC		30108239
283	Phosphorylation	KEASCDESDVGTNDY ECCCCCHHCCCCCCC		30108239
287	Phosphorylation	CDESDVGTNDYDMEH CCHHCCCCCCCCCCC		30108239
288	Phosphorylation	DESDVGTNDYDMEHS CHHCCCCCCCCCCCC		27251275
290	Phosphorylation	SDVGTNDYDMEHSTV HCCCCCCCCCCCCCC		27732954
295	Phosphorylation	NDYDMEHSTVKESVS CCCCCCCCCCCCCCC		27732954
296	Phosphorylation	DYDMEHSTVKESVST CCCCCCCCCCCCCCC		30177828
302	Phosphorylation	STVKESVSTNNRVQY CCCCCCCCCCCCEEE		30576142
303	Phosphorylation	TVKESVSTNNRVQYE CCCCCCCCCCCEEEC		30576142
321	Phosphorylation	LAPLREDSVLRELDR HHCCCCCHHHHHHCC		28348404
330	Phosphorylation	LRELDREDKASDDEM HHHHCCCCCCCCCCC		27251275
333	Phosphorylation	LDREDKASDDEMMTP HCCCCCCCCCCCCCC		23401153
339	Phosphorylation	ASDDEMMTPESERVQ CCCCCCCCCHHHCEE		27732954
342	Phosphorylation	DEMMTPESERVQVEG CCCCCCHHHCEEEEC		28122231
495	Phosphorylation	FHCELVNSLSVKSEA HHHHHHHHCCCCCCC		26074081
497	Phosphorylation	CELVNSLSVKSEALS HHHHHHCCCCCCCCC		26074081
500	Phosphorylation	VNSLSVKSEALSLPT HHHCCCCCCCCCCCC		22210691
507	Phosphorylation	SEALSLPTVRDWTLE CCCCCCCCCCCCCCC		-
516	Phosphorylation	RDWTLEDSSQELWK- CCCCCCCCHHHHCC-		17525332
517	Phosphorylation	DWTLEDSSQELWK-- CCCCCCCHHHHCC--		17525332
525	Phosphorylation	QELWK---------- HHHCC----------		27251275
526	Phosphorylation	ELWK----------- HHCC-----------		27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZBT18_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZBT18_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZBT18_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DNM3A_HUMAN	DNMT3A	physical	11350943
DNM3A_HUMAN	DNMT3A	physical	15616584
ZBT42_HUMAN	ZBTB42	physical	28514442
ATX1L_HUMAN	ATXN1L	physical	28514442
CIC_HUMAN	CIC	physical	28514442
ZN131_HUMAN	ZNF131	physical	28514442
CP4FC_HUMAN	CYP4F12	physical	28514442
ZBTB3_HUMAN	ZBTB3	physical	28514442
RCBT2_HUMAN	RCBTB2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 612337: Mental retardation, autosomal dominant 22 (MRD22)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.