| UniProt ID | CP4FC_HUMAN | |
|---|---|---|
| UniProt AC | Q9HCS2 | |
| Protein Name | Cytochrome P450 4F12 | |
| Gene Name | CYP4F12 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 524 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Multi-pass membrane protein. Microsome membrane Multi-pass membrane protein. |
|
| Protein Description | Catalyzes leukotriene B4 omega-hydroxylation and arachidonic acid omega-hydroxylation but with an activity much lower than that of CYP4F2. Catalyzes the hydroxylation of the antihistamine ebastine.. | |
| Protein Sequence | MSLLSLPWLGLRPVATSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWFWGHLGLITPTEEGLKNSTQMSATYSQGFTIWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSCLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLNVSLQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 56 | Ubiquitination | QCFPQPPKRNWFWGH CCCCCCCCCCCCHHH | 66.11 | 29901268 | |
| 152 | Phosphorylation | SRHRRMLTPAFHFNI HHHHHCCCHHHHHHH | 11.83 | - | |
| 162 | Phosphorylation | FHFNILKSYITIFNK HHHHHHHHHHHHEEC | 20.51 | 21949786 | |
| 163 | Phosphorylation | HFNILKSYITIFNKS HHHHHHHHHHHEECC | 10.65 | 21949786 | |
| 196 | Phosphorylation | LDMFEHISLMTLDSL HHHHHHHHHHCHHHH | 17.62 | - | |
| 294 | Ubiquitination | FKDKAKSKTLDFIDV HHHHHHCCCCCHHEE | 53.02 | 21906983 | |
| 306 | Ubiquitination | IDVLLLSKDEDGKAL HEEEECCCCCCCCCC | 66.17 | 29901268 | |
| 314 | Phosphorylation | DEDGKALSDEDIRAE CCCCCCCCHHHHHHH | 43.76 | - | |
| 314 | O-linked_Glycosylation | DEDGKALSDEDIRAE CCCCCCCCHHHHHHH | 43.76 | 30620550 | |
| 332 | Phosphorylation | FMFGGHDTTASGLSW EEECCCCCHHHHHHH | 20.70 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CP4FC_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CP4FC_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CP4FC_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SODM_HUMAN | SOD2 | physical | 21988832 | |
| HSP76_HUMAN | HSPA6 | physical | 21988832 | |
| CP4F2_HUMAN | CYP4F2 | physical | 28514442 | |
| CP4F8_HUMAN | CYP4F8 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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