| UniProt ID | CP4F8_HUMAN | |
|---|---|---|
| UniProt AC | P98187 | |
| Protein Name | Cytochrome P450 4F8 | |
| Gene Name | CYP4F8 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 520 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Single-pass membrane protein. Microsome membrane. |
|
| Protein Description | Hydroxylates arachidonic acid (20:4n-6) to (18R)-hydroxyarachidonate. Shows little activity against prostaglandin (PG) D2, PGE1, PGE2, PGF2alpha, and leukotriene B4. Catalyzes omega-2 and omega-3-hydroxylation of PGH1 and PGH2. Catalyzes epoxidation of 4,7,10,13,16,19-(Z)-docosahexaenoic acid (22:6n-3) and 7,10,13,16,19-(Z)-docosapentaenoic acid (22:5n-3) and omega-3-hydroxylation of 4,7,10,13,16-(Z)-docosapentaenoic acid (22:5n-6). Catalyzes hydroxylation of PGI2 and carbaprostacyclin.. | |
| Protein Sequence | MSLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWFLGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDKDIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILPDHREPRRTPEIVLRAEDGLWLRVEPLG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSLLSLSWL ------CCCHHCHHC | 37.71 | 25002506 | |
| 152 | Phosphorylation | RHHRRLLTPAFHFNI HHHHHCCCHHHHHHC | 19.70 | - | |
| 168 | Phosphorylation | KPYIKIFSKSANIMH HHHHHHHHCCCCHHH | 29.22 | 24719451 | |
| 170 | Phosphorylation | YIKIFSKSANIMHAK HHHHHHCCCCHHHHH | 25.91 | 24719451 | |
| 187 | Phosphorylation | RLAMEGSTCLDVFEH HHHHCCCCHHHHHHH | 28.13 | 27762562 | |
| 290 | Ubiquitination | VDDFLQAKAKSKTLD HHHHHHHHHHCCCCC | 43.30 | 27667366 | |
| 292 | Ubiquitination | DFLQAKAKSKTLDFI HHHHHHHHCCCCCHH | 52.34 | 23503661 | |
| 294 | Ubiquitination | LQAKAKSKTLDFIDV HHHHHHCCCCCHHHH | 53.02 | 21906983 | |
| 314 | Phosphorylation | DKNGKELSDEDIRAE CCCCCCCCHHHHHHH | 39.79 | - | |
| 332 | Phosphorylation | FMFGGHDTTASGLSW EEECCCCCHHHHHHH | 20.70 | - | |
| 388 | Phosphorylation | LTMCLKESLRLHPPI HHHHHHHHHCCCCCC | 19.73 | - | |
| 397 | Phosphorylation | RLHPPIPTFARGCTQ CCCCCCCCCCCCCCC | 30.55 | - | |
| 501 | Phosphorylation | DHREPRRTPEIVLRA CCCCCCCCCCEEEEC | 26.93 | 24114839 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CP4F8_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CP4F8_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CP4F8_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of CP4F8_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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