CP4F2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CP4F2_HUMAN
• UniProt AC: P78329
• Protein Name: Phylloquinone omega-hydroxylase CYP4F2 {ECO:0000305}
• Gene Name: CYP4F2 {ECO:0000312|HGNC:HGNC:2645}
• Organism: Homo sapiens (Human).
• Sequence Length: 520
• Subcellular Localization: Microsome membrane ; Peripheral membrane protein . Endoplasmic reticulum membrane ; Peripheral membrane protein .
• Protein Description: Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation. [PubMed: 19297519]
• Protein Sequence: MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MSQLSLSWLGLWPV -CCCCCHHHHCCCHH	19.51	-
125	Phosphorylation	APKDKFFYSFLEPWL CCCCHHHHHHHHHHH	11.14	24719451
126	Phosphorylation	PKDKFFYSFLEPWLG CCCHHHHHHHHHHHC	20.42	24719451
139	Phosphorylation	LGDGLLLSAGDKWSR HCCCCEECCCCHHHH	30.12	24719451
141	Ubiquitination	DGLLLSAGDKWSRHR CCCEECCCCHHHHHH	33.39	-
152	Phosphorylation	SRHRRMLTPAFHFNI HHHHHCCCHHHCHHH	11.83	-
170	Phosphorylation	YMKIFNESVNIMHAK HHHHHHCCCCHHHHH	22.90	26434776
196	Phosphorylation	LDMFEHISLMTLDSL HHHHHHHHHHCHHHH	17.62	-
221	Phosphorylation	CQEKPSEYIAAILEL HCCCHHHHHHHHHHH	10.53	-
290	Ubiquitination	VDDFLQAKAKSKTLD HHHHHHHHHHCCCCC	43.30	33845483
292	Acetylation	DFLQAKAKSKTLDFI HHHHHHHHCCCCCHH	52.34	20167786
292	Ubiquitination	DFLQAKAKSKTLDFI HHHHHHHHCCCCCHH	52.34	23503661
294	Acetylation	LQAKAKSKTLDFIDV HHHHHHCCCCCHHHE	53.02	20167786
294	Ubiquitination	LQAKAKSKTLDFIDV HHHHHHCCCCCHHHE	53.02	2190698
306	Ubiquitination	IDVLLLSKDEDGKKL HHEEECCCCCCCCCC	66.17	29901268
311	Ubiquitination	LSKDEDGKKLSDEDI CCCCCCCCCCCHHHH	63.96	23503661
312	Ubiquitination	SKDEDGKKLSDEDIR CCCCCCCCCCHHHHH	59.77	23503661
346	Acetylation	WVLYHLAKHPEYQER HHHHHHHHCHHHHHH	67.08	20167786
501	Ubiquitination	DHTEPRRKPELVLRA CCCCCCCCCEEEEEE	44.09	23503661

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CP4F2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CP4F2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CP4F2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 122700: Coumarin resistance (CMRES)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB08868: Fingolimod