| UniProt ID | ZBT42_HUMAN | |
|---|---|---|
| UniProt AC | B2RXF5 | |
| Protein Name | Zinc finger and BTB domain-containing protein 42 | |
| Gene Name | ZBTB42 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 422 | |
| Subcellular Localization | Cytoplasm . Nucleus . Nucleus, nucleoplasm . In skeletal myofibers, highly enriched in subsynaptic nuclei at the neuromuscular junctions. | |
| Protein Description | Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes.. | |
| Protein Sequence | MEFPEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRPAGSRDTVRLNGDIVTAPAFGRLLDFMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVCKGRLQEKDRSLDPGNPAPGAEPAQPPCPWPVWTADLCPAARKAKLPPFGVKAALPPRASGPPPCQVPEESDQALDLSLKSGPRQERVHPPCVLQTPLCSQRQPGAQPLVKDERDSLSEQEESSSSRSPHSPPKPPPVPAAKGLVVGLQPLPLSGEGSRELELGAGRLASEDELGPGGPLCICPLCSKLFPSSHVLQLHLSAHFRERDSTRARLSPDGVAPTCPLCGKTFSCTYTLKRHERTHSGEKPYTCVQCGKSFQYSHNLSRHTVVHTREKPHACRWCERRFTQSGDLYRHVRKFHCGLVKSLLV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 84 | Phosphorylation | GRLLDFMYEGRLDLR HHHHHHHHCCCCCCC | 18.41 | 22210691 | |
| 241 | Phosphorylation | EESSSSRSPHSPPKP HHHHCCCCCCCCCCC | 28.98 | 28348404 | |
| 244 | Phosphorylation | SSSRSPHSPPKPPPV HCCCCCCCCCCCCCC | 46.40 | 25849741 | |
| 247 | Methylation | RSPHSPPKPPPVPAA CCCCCCCCCCCCCCC | 73.81 | - | |
| 267 | Phosphorylation | GLQPLPLSGEGSREL EEEECCCCCCCCCEE | 32.62 | 24247654 | |
| 271 | Phosphorylation | LPLSGEGSRELELGA CCCCCCCCCEEEECC | 20.48 | 24247654 | |
| 328 | Phosphorylation | DSTRARLSPDGVAPT CCCCCCCCCCCCCCC | 18.52 | 25849741 | |
| 335 | Phosphorylation | SPDGVAPTCPLCGKT CCCCCCCCCCCCCCE | 19.61 | 28102081 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ZBT42_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ZBT42_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ZBT42_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ANM9_HUMAN | PRMT9 | physical | 28514442 | |
| FXL17_HUMAN | FBXL17 | physical | 28514442 | |
| VRK1_HUMAN | VRK1 | physical | 28514442 | |
| RN187_HUMAN | RNF187 | physical | 28514442 | |
| TRI18_HUMAN | MID1 | physical | 28514442 | |
| ZN516_HUMAN | ZNF516 | physical | 28514442 | |
| CTBP2_HUMAN | CTBP2 | physical | 28514442 | |
| ZPR1_HUMAN | ZPR1 | physical | 28514442 | |
| GGPPS_HUMAN | GGPS1 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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