UniProt ID | ZN516_HUMAN | |
---|---|---|
UniProt AC | Q92618 | |
Protein Name | Zinc finger protein 516 {ECO:0000312|HGNC:HGNC:28990} | |
Gene Name | ZNF516 {ECO:0000312|HGNC:HGNC:28990} | |
Organism | Homo sapiens (Human). | |
Sequence Length | 1163 | |
Subcellular Localization | Nucleus . | |
Protein Description | Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis (By similarity). May also play a role in the cellular response to replication stress. [PubMed: 23446422] | |
Protein Sequence | MDRNREAEMELRRGPSPTRAGRGHEVDGDKATCHTCCICGKSFPFQSSLSQHMRKHTGEKPYKCPYCDHRASQKGNLKIHIRSHRTGTLIQGHEPEAGEAPLGEMRASEGLDACASPTKSASACNRLLNGASQADGARVLNGASQADSGRVLLRSSKKGAEGSACAPGEAKAAVQCSFCKSQFERKKDLELHVHQAHKPFKCRLCSYATLREESLLSHIERDHITAQGPGSGEACVENGKPELSPGEFPCEVCGQAFSQTWFLKAHMKKHRGSFDHGCHICGRRFKEPWFLKNHMKAHGPKTGSKNRPKSELDPIATINNVVQEEVIVAGLSLYEVCAKCGNLFTNLDSLNAHNAIHRRVEASRTRAPAEEGAEGPSDTKQFFLQCLNLRPSAAGDSCPGTQAGRRVAELDPVNSYQAWQLATRGKVAEPAEYLKYGAWDEALAGDVAFDKDRREYVLVSQEKRKREQDAPAAQGPPRKRASGPGDPAPAGHLDPRSAARPNRRAAATTGQGKSSECFECGKIFRTYHQMVLHSRVHRRARRERDSDGDRAARARCGSLSEGDSASQPSSPGSACAAADSPGSGLADEAAEDSGEEGAPEPAPGGQPRRCCFSEEVTSTELSSGDQSHKMGDNASERDTGESKAGIAASVSILENSSRETSRRQEQHRFSMDLKMPAFHPKQEVPVPGDGVEFPSSTGAEGQTGHPAEKLSDLHNKEHSGGGKRALAPDLMPLDLSARSTRDDPSNKETASSLQAALVVHPCPYCSHKTYYPEVLWMHKRIWHRVSCNSVAPPWIQPNGYKSIRSNLVFLSRSGRTGPPPALGGKECQPLLLARFTRTQVPGGMPGSKSGSSPLGVVTKAASMPKNKESHSGGPCALWAPGPDGYRQTKPCHGQEPHGAATQGPLAKPRQEASSKPVPAPGGGGFSRSATPTPTVIARAGAQPSANSKPVEKFGVPPAGAGFAPTNKHSAPDSLKAKFSAQPQGPPPAKGEGGAPPLPPREPPSKAAQELRTLATCAAGSRGDAALQAQPGVAGAPPVLHSIKQEPVAEGHEKRLDILNIFKTYIPKDFATLYQGWGVSGPGLEHRGTLRTQARPGEFVCIECGKSFHQPGHLRAHMRAHSVVFESDGPRGSEVHTTSADAPKQGRDHSNTGTVQTVPLRKGT | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
|
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
16 | Phosphorylation | MELRRGPSPTRAGRG HHHHCCCCCCCCCCC | 41.55 | 28555341 | |
18 | Phosphorylation | LRRGPSPTRAGRGHE HHCCCCCCCCCCCCC | 37.17 | 28102081 | |
42 | Phosphorylation | TCCICGKSFPFQSSL EEECCCCCCCCCHHH | 24.36 | - | |
47 | Phosphorylation | GKSFPFQSSLSQHMR CCCCCCCHHHHHHHH | 33.36 | - | |
57 | Phosphorylation | SQHMRKHTGEKPYKC HHHHHHHCCCCCCCC | 50.50 | 23532336 | |
86 | Phosphorylation | IHIRSHRTGTLIQGH EEEEECCCCCEEECC | 29.15 | - | |
88 | Phosphorylation | IRSHRTGTLIQGHEP EEECCCCCEEECCCC | 21.78 | - | |
108 | Phosphorylation | PLGEMRASEGLDACA CCCCCHHCCCCCCCC | 23.10 | 26552605 | |
116 | Phosphorylation | EGLDACASPTKSASA CCCCCCCCCCCCHHH | 32.74 | 19664994 | |
118 | Phosphorylation | LDACASPTKSASACN CCCCCCCCCCHHHHH | 34.83 | 30266825 | |
120 | Phosphorylation | ACASPTKSASACNRL CCCCCCCCHHHHHHH | 29.90 | 23312004 | |
122 | Phosphorylation | ASPTKSASACNRLLN CCCCCCHHHHHHHHC | 40.21 | 23312004 | |
132 | Phosphorylation | NRLLNGASQADGARV HHHHCCCCCCCCCEE | 27.57 | 26714015 | |
144 | Phosphorylation | ARVLNGASQADSGRV CEECCCCCCCCCCCE | 27.57 | 26714015 | |
214 | Phosphorylation | YATLREESLLSHIER CHHHCHHHHHHHHHH | 29.83 | 30266825 | |
217 | Phosphorylation | LREESLLSHIERDHI HCHHHHHHHHHHHCC | 27.93 | 30266825 | |
273 | Phosphorylation | HMKKHRGSFDHGCHI HHHHHCCCCCCCCCC | 27.71 | 27251275 | |
456 | Phosphorylation | FDKDRREYVLVSQEK ECCCCCCEEEEEHHH | 9.40 | 27642862 | |
460 | Phosphorylation | RREYVLVSQEKRKRE CCCEEEEEHHHHHHH | 28.58 | - | |
465 | Ubiquitination | LVSQEKRKREQDAPA EEEHHHHHHHCCCCH | 71.94 | - | |
479 | Ubiquitination | AAQGPPRKRASGPGD HHHCCCCCCCCCCCC | 59.08 | - | |
482 | Phosphorylation | GPPRKRASGPGDPAP CCCCCCCCCCCCCCC | 49.94 | 28985074 | |
514 | Phosphorylation | ATTGQGKSSECFECG CCCCCCCCHHHHHHH | 37.89 | - | |
527 | Phosphorylation | CGKIFRTYHQMVLHS HHHHHHHHHHHHHHH | 5.94 | 24719451 | |
534 | Phosphorylation | YHQMVLHSRVHRRAR HHHHHHHHHHHHHHH | 31.66 | 24719451 | |
635 | Phosphorylation | HKMGDNASERDTGES CCCCCCHHHCCCCCC | 39.14 | - | |
643 | Sumoylation | ERDTGESKAGIAASV HCCCCCCHHHHHHHH | 46.46 | 28112733 | |
649 | Phosphorylation | SKAGIAASVSILENS CHHHHHHHHHHHHCC | 13.84 | 23312004 | |
651 | Phosphorylation | AGIAASVSILENSSR HHHHHHHHHHHCCCH | 20.96 | 24173317 | |
656 | Phosphorylation | SVSILENSSRETSRR HHHHHHCCCHHHHHH | 22.77 | 23312004 | |
657 | Phosphorylation | VSILENSSRETSRRQ HHHHHCCCHHHHHHH | 45.80 | 23312004 | |
670 | Phosphorylation | RQEQHRFSMDLKMPA HHHHHCHHHCCCCCC | 16.02 | 24719451 | |
681 | Sumoylation | KMPAFHPKQEVPVPG CCCCCCCCCCCCCCC | 50.99 | 28112733 | |
731 | Sulfoxidation | RALAPDLMPLDLSAR CCCCCCCCCCCCCCC | 3.95 | 21406390 | |
736 | Phosphorylation | DLMPLDLSARSTRDD CCCCCCCCCCCCCCC | 22.69 | - | |
779 | Acetylation | PEVLWMHKRIWHRVS CHHHHHHHCHHHCCC | 29.49 | 23236377 | |
786 | Phosphorylation | KRIWHRVSCNSVAPP HCHHHCCCCCCCCCC | 13.92 | 26552605 | |
789 | Phosphorylation | WHRVSCNSVAPPWIQ HHCCCCCCCCCCCCC | 24.80 | 26552605 | |
800 | Phosphorylation | PWIQPNGYKSIRSNL CCCCCCCCHHHHHCE | 14.27 | 26552605 | |
802 | Phosphorylation | IQPNGYKSIRSNLVF CCCCCCHHHHHCEEE | 18.10 | 26552605 | |
805 | Phosphorylation | NGYKSIRSNLVFLSR CCCHHHHHCEEEEEC | 32.61 | 26552605 | |
811 | Phosphorylation | RSNLVFLSRSGRTGP HHCEEEEECCCCCCC | 16.97 | 26552605 | |
836 | Phosphorylation | PLLLARFTRTQVPGG HHHHHHEECCCCCCC | 27.53 | 26657352 | |
838 | Phosphorylation | LLARFTRTQVPGGMP HHHHEECCCCCCCCC | 30.75 | 26657352 | |
849 | Phosphorylation | GGMPGSKSGSSPLGV CCCCCCCCCCCCCHH | 45.67 | 23403867 | |
851 | Phosphorylation | MPGSKSGSSPLGVVT CCCCCCCCCCCHHHE | 35.55 | 30266825 | |
852 | Phosphorylation | PGSKSGSSPLGVVTK CCCCCCCCCCHHHEE | 27.89 | 23401153 | |
858 | Phosphorylation | SSPLGVVTKAASMPK CCCCHHHEEHHHCCC | 16.74 | 24667141 | |
862 | Phosphorylation | GVVTKAASMPKNKES HHHEEHHHCCCCCCC | 40.24 | 23403867 | |
901 | Phosphorylation | QEPHGAATQGPLAKP CCCCCCCCCCCCCCC | 33.26 | 28348404 | |
926 | Phosphorylation | APGGGGFSRSATPTP CCCCCCCCCCCCCCC | 28.71 | 27732954 | |
928 | Phosphorylation | GGGGFSRSATPTPTV CCCCCCCCCCCCCCE | 34.98 | 26657352 | |
930 | Phosphorylation | GGFSRSATPTPTVIA CCCCCCCCCCCCEEE | 29.01 | 30266825 | |
932 | Phosphorylation | FSRSATPTPTVIARA CCCCCCCCCCEEECC | 27.51 | 23403867 | |
934 | Phosphorylation | RSATPTPTVIARAGA CCCCCCCCEEECCCC | 27.33 | 23403867 | |
952 | Acetylation | ANSKPVEKFGVPPAG CCCCCCHHHCCCCCC | 47.88 | 19813489 | |
969 | Phosphorylation | FAPTNKHSAPDSLKA CCCCCCCCCCHHHHH | 43.01 | 22468782 | |
973 | Phosphorylation | NKHSAPDSLKAKFSA CCCCCCHHHHHHCCC | 30.61 | 22468782 | |
1043 | Sumoylation | PPVLHSIKQEPVAEG CCCCCCCCCCCCCCC | 52.18 | 28112733 | |
1062 | Sumoylation | LDILNIFKTYIPKDF HHHHHHHHHHCCCHH | 36.30 | 28112733 | |
1086 | Dimethylation | SGPGLEHRGTLRTQA CCCCCCCCCEECCCC | 30.34 | - | |
1086 | Methylation | SGPGLEHRGTLRTQA CCCCCCCCCEECCCC | 30.34 | 30763575 | |
1088 | Phosphorylation | PGLEHRGTLRTQARP CCCCCCCEECCCCCC | 17.02 | - | |
1121 | Phosphorylation | RAHMRAHSVVFESDG HHHHEEEEEEEECCC | 20.99 | 28450419 | |
1137 | O-linked_Glycosylation | RGSEVHTTSADAPKQ CCCEEEECCCCCCCC | 13.67 | 30620550 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ZN516_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ZN516_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ZN516_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
H31T_HUMAN | HIST3H3 | physical | 12700765 |
Kegg Disease | ||||||
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There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-116; THR-118; SER-852AND THR-930, AND MASS SPECTROMETRY. | |
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-116, AND MASSSPECTROMETRY. |