| UniProt ID | UBP27_HUMAN | |
|---|---|---|
| UniProt AC | A6NNY8 | |
| Protein Name | Ubiquitin carboxyl-terminal hydrolase 27 | |
| Gene Name | USP27X | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 438 | |
| Subcellular Localization | Cytoplasm, cytosol . Nucleus . | |
| Protein Description | Deubiquitinase that can reduce the levels of BCL2L11/BIM ubiquitination and stabilize BCL2L11 in response to the RAF-MAPK-degradation signal. By acting on BCL2L11 levels, may counteract the anti-apoptotic effects of MAPK activity.. | |
| Protein Sequence | MCKDYVYDKDIEQIAKEEQGEALKLQASTSTEVSHQQCSVPGLGEKFPTWETTKPELELLGHNPRRRRITSSFTIGLRGLINLGNTCFMNCIVQALTHTPILRDFFLSDRHRCEMPSPELCLVCEMSSLFRELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQDAHEFLIAALDVLHRHCKGDDVGKAANNPNHCNCIIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISLDLPGSCTSFWPMSPGRESSVNGESHIPGITTLTDCLRRFTRPEHLGSSAKIKCGSCQSYQESTKQLTMNKLPVVACFHFKRFEHSAKQRRKITTYISFPLELDMTPFMASSKESRMNGQLQLPTNSGNNENKYSLFAVVNHQGTLESGHYTSFIRHHKDQWFKCDDAVITKASIKDVLDSEGYLLFYHKQVLEHESEKVKEMNTQAY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 54 | Ubiquitination | FPTWETTKPELELLG CCCCCCCCHHHHHCC | 43.87 | 21890473 | |
| 54 | Acetylation | FPTWETTKPELELLG CCCCCCCCHHHHHCC | 43.87 | 23236377 | |
| 70 | Phosphorylation | NPRRRRITSSFTIGL CCCCCCCCCCEEEEH | 19.26 | 24719451 | |
| 71 | Phosphorylation | PRRRRITSSFTIGLR CCCCCCCCCEEEEHH | 22.53 | 29978859 | |
| 72 | Phosphorylation | RRRRITSSFTIGLRG CCCCCCCCEEEEHHH | 20.12 | 29978859 | |
| 110 | Methylation | RDFFLSDRHRCEMPS HHHHCCCCCCCCCCC | 18.77 | - | |
| 128 | Phosphorylation | CLVCEMSSLFRELYS HHHHHHHHHHHHHHC | 30.16 | 24719451 | |
| 278 | Phosphorylation | TRPEHLGSSAKIKCG CCHHHHCCCCEEECC | 33.22 | 29214152 | |
| 279 | Phosphorylation | RPEHLGSSAKIKCGS CHHHHCCCCEEECCC | 31.61 | 29214152 | |
| 281 | Ubiquitination | EHLGSSAKIKCGSCQ HHHCCCCEEECCCCH | 44.65 | 32015554 | |
| 298 | Phosphorylation | QESTKQLTMNKLPVV HHHHHCCCCCCCCEE | 19.06 | 29759185 | |
| 325 | Phosphorylation | KQRRKITTYISFPLE HHHHCCEEEEECEEE | 23.49 | 29759185 | |
| 326 | Phosphorylation | QRRKITTYISFPLEL HHHCCEEEEECEEEC | 5.97 | 29759185 | |
| 328 | Phosphorylation | RKITTYISFPLELDM HCCEEEEECEEECCC | 15.48 | 29759185 | |
| 355 | Phosphorylation | NGQLQLPTNSGNNEN CCEEECCCCCCCCCC | 51.08 | 25072903 | |
| 357 | Phosphorylation | QLQLPTNSGNNENKY EEECCCCCCCCCCCE | 45.43 | 25072903 | |
| 386 | Methylation | GHYTSFIRHHKDQWF CCCHHHHCCCCCCCE | 24.69 | - | |
| 406 | Ubiquitination | VITKASIKDVLDSEG EEEECHHHHHHCCCC | 39.01 | 21890473 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of UBP27_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of UBP27_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of UBP27_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| UBC_HUMAN | UBC | physical | 27013495 | |
| B2L11_HUMAN | BCL2L11 | physical | 27013495 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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