CSN4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CSN4_MOUSE
• UniProt AC: O88544
• Protein Name: COP9 signalosome complex subunit 4
• Gene Name: Cops4
• Organism: Mus musculus (Mouse).
• Sequence Length: 406
• Subcellular Localization: Cytoplasm. Nucleus. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.
• Protein Description: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity)..
• Protein Sequence: MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGTEQLEALKAFVEAMVNENVSLVISRQLLTDFCTHLPNLPDSTAKEVYHFTLEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKATTADGSSILDRAVIEHNLLSASKLYNNITFEELGALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETREALPTWDKQIQSLCFQVNNLLEKISQTAPEWTAQAMEAQMAQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAAVRQDL ------CCHHHHHHH	12.25	-
15	Phosphorylation	DLAQLMNSSGSHKDL HHHHHHCCCCCCHHH	23.31	21659604
18	Phosphorylation	QLMNSSGSHKDLAGK HHHCCCCCCHHHHHH	29.34	28059163
25	Acetylation	SHKDLAGKYRQILEK CCHHHHHHHHHHHHH	31.49	-
25	Malonylation	SHKDLAGKYRQILEK CCHHHHHHHHHHHHH	31.49	26320211
70	S-nitrosocysteine	RQLLTDFCTHLPNLP HHHHHHHHHCCCCCC	2.33	-
70	S-nitrosylation	RQLLTDFCTHLPNLP HHHHHHHHHCCCCCC	2.33	20925432
143	Phosphorylation	QKQYNVDYKLETYLK CCEECCCHHHHHHHH	17.12	-
148	Phosphorylation	VDYKLETYLKIARLY CCHHHHHHHHHHHHH	9.16	-
237	Phosphorylation	LHCTILASAGQQRSR HHHHHHHCCHHHHHH	29.50	28464351
251	Acetylation	RMLATLFKDERCQQL HHHHHHHCCHHHHHH	62.89	22826441
297	Phosphorylation	KATTADGSSILDRAV CCCCCCCCCHHHHHH	18.11	-
298	Phosphorylation	ATTADGSSILDRAVI CCCCCCCCHHHHHHH	32.47	-
337	Ubiquitination	IPAAKAEKIASQMIT CHHHHHHHHHHHHHH	48.72	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CSN4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CSN4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CSN4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSN6_MOUSE	Cops6	physical	22956996

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.