KLHL5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLHL5_HUMAN
• UniProt AC: Q96PQ7
• Protein Name: Kelch-like protein 5
• Gene Name: KLHL5
• Organism: Homo sapiens (Human).
• Sequence Length: 755
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Sequence: MNVIYFPLHIFVVYSRAYTSLVLVGCTNLCAVLFARCLDDHLVSLRMSGSRKEFDVKQILKIRWRWFGHQASSPNSTVDSQQGEFWNRGQTGANGGRKFLDPCSLQLPLASIGYRRSSQLDFQNSPSWPMASTSEVPAFEFTAEDCGGAHWLDRPEVDDGTSEEENESDSSSCRTSNSSQTLSSCHTMEPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	CLDDHLVSLRMSGSR HHHHHHHHEEECCCC	19.33	24719451
52	Acetylation	LRMSGSRKEFDVKQI EEECCCCCCCCHHHH	65.51	12431693
57	Acetylation	SRKEFDVKQILKIRW CCCCCCHHHHEEEEE	33.20	12431703
57	Ubiquitination	SRKEFDVKQILKIRW CCCCCCHHHHEEEEE	33.20	-
61	Acetylation	FDVKQILKIRWRWFG CCHHHHEEEEEHCCC	31.67	12431713
456	Phosphorylation	ERRPMLQSPRTKPRK CCCCCCCCCCCCCCC	16.64	21712546
526	Ubiquitination	VGGRDGLKTLNTVEC EECCCCCCCCCEEEE	57.40	-
527	Phosphorylation	GGRDGLKTLNTVECY ECCCCCCCCCEEEEE	30.22	28509920
530	Phosphorylation	DGLKTLNTVECYNPK CCCCCCCEEEEECCC	22.31	28509920
534	Phosphorylation	TLNTVECYNPKTKTW CCCEEEEECCCCCEE	22.46	28509920
537	Ubiquitination	TVECYNPKTKTWSVM EEEEECCCCCEEECC	60.04	-
619	Phosphorylation	AVGGRDGSSCLKSVE EECCCCCCCCCCEEE	23.36	22210691
620	Phosphorylation	VGGRDGSSCLKSVEC ECCCCCCCCCCEEEE	29.06	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLHL5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLHL5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLHL5_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of KLHL5_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.