| UniProt ID | RPH3L_MOUSE | |
|---|---|---|
| UniProt AC | Q768S4 | |
| Protein Name | Rab effector Noc2 | |
| Gene Name | Rph3al | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 302 | |
| Subcellular Localization | Cytoplasm. Cytoplasmic vesicle, secretory vesicle membrane. Recruited to the exocytic secretory vesicles by RAB27A. | |
| Protein Description | Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells. Regulates the exocytosis of dense-core vesicles in neuroendocrine cells through interaction with RAB27A. Acts as a potential RAB3B effector protein in epithelial cells.. | |
| Protein Sequence | MADTIFSSGNDQWVCPNDRQLALRAKLQTGWSVHTYQTEKQRRSQCLSPGELEIILQVIQRAERLDILEQQRIGRLVERLETMQRNVMGNGLSQCLLCGEVLGFLGSSSVFCKDCRKKVCTKCGIEASPGQKRPLWLCKICSEQREVWKRSGAWFYKGLPKYILPLKTPGRADDPHFRPLPVEPTETQPPSAETSRVYTWARGRVVSSDSDSDSDLSSSSLEDRPLPSGVKGTKGDKPRGDSGASMESPRLGPARPPSHLSGSQSSLGSEAGTGATEPQGGTPAQPEPRVPGKRHTWATPRY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 117 | Acetylation | VFCKDCRKKVCTKCG EECHHHHHHHHHHCC | 56.75 | 15608119 | |
| 122 | Acetylation | CRKKVCTKCGIEASP HHHHHHHHCCCCCCC | 25.90 | 15608127 | |
| 122 | Sumoylation | CRKKVCTKCGIEASP HHHHHHHHCCCCCCC | 25.90 | 28289178 | |
| 142 | Phosphorylation | LWLCKICSEQREVWK CHHHHHCHHHHHHHH | 39.99 | 26239621 | |
| 168 | Phosphorylation | KYILPLKTPGRADDP EEEEECCCCCCCCCC | 38.36 | 27841257 | |
| 191 | Phosphorylation | PTETQPPSAETSRVY CCCCCCCCCCCCCEE | 45.48 | 27841257 | |
| 198 | Phosphorylation | SAETSRVYTWARGRV CCCCCCEEEEECCCE | 8.75 | 21183079 | |
| 248 | Phosphorylation | DSGASMESPRLGPAR CCCCCCCCCCCCCCC | 13.48 | 16141072 | |
| 258 | Phosphorylation | LGPARPPSHLSGSQS CCCCCCCHHHCCCCC | 39.48 | 24759943 | |
| 261 | Phosphorylation | ARPPSHLSGSQSSLG CCCCHHHCCCCCCCC | 30.86 | 24759943 | |
| 263 | Phosphorylation | PPSHLSGSQSSLGSE CCHHHCCCCCCCCCC | 24.42 | 21183079 | |
| 265 | Phosphorylation | SHLSGSQSSLGSEAG HHHCCCCCCCCCCCC | 29.27 | 27841257 | |
| 266 | Phosphorylation | HLSGSQSSLGSEAGT HHCCCCCCCCCCCCC | 29.16 | 27841257 | |
| 273 | Phosphorylation | SLGSEAGTGATEPQG CCCCCCCCCCCCCCC | 30.59 | 21183079 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RPH3L_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RPH3L_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RPH3L_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RAB3A_MOUSE | Rab3a | physical | 15159548 | |
| RAB3B_MOUSE | Rab3b | physical | 15159548 | |
| RAB3C_MOUSE | Rab3c | physical | 15159548 | |
| RAB3D_MOUSE | Rab3d | physical | 15159548 | |
| RAB3A_MOUSE | Rab3a | physical | 12578829 | |
| RAB3B_MOUSE | Rab3b | physical | 12578829 | |
| RAB3C_MOUSE | Rab3c | physical | 12578829 | |
| RAB3D_MOUSE | Rab3d | physical | 12578829 | |
| RAB8A_MOUSE | Rab8a | physical | 12578829 | |
| RB27A_MOUSE | Rab27a | physical | 12578829 | |
| RB27B_MOUSE | Rab27b | physical | 12578829 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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