SC6A3_HUMAN - dbPTM
SC6A3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SC6A3_HUMAN
UniProt AC Q01959
Protein Name Sodium-dependent dopamine transporter
Gene Name SLC6A3
Organism Homo sapiens (Human).
Sequence Length 620
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals..
Protein Sequence MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKDRELVDRGEVRQFTLRHWLKV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSKSKCSVG
------CCCCCCCCC		45.7116908408
4Phosphorylation----MSKSKCSVGLM
----CCCCCCCCCCC		31.4216908408
5Ubiquitination---MSKSKCSVGLMS
---CCCCCCCCCCCC		33.98-
7Phosphorylation-MSKSKCSVGLMSSV
-CCCCCCCCCCCCCC		23.9822817900
12PhosphorylationKCSVGLMSSVVAPAK
CCCCCCCCCCEECCC		25.6422817900
13PhosphorylationCSVGLMSSVVAPAKE
CCCCCCCCCEECCCC		13.4722817900
48PhosphorylationQLTSSTLTNPRQSPV
ECEECCCCCCCCCCC		43.17-
53PhosphorylationTLTNPRQSPVEAQDR
CCCCCCCCCCCCCCH		31.9925332170
62PhosphorylationVEAQDRETWGKKIDF
CCCCCHHHHHHHHHH		40.1722817900
181N-linked_GlycosylationELPWIHCNNSWNSPN
CCCEEECCCCCCCCC		31.2612429746
181N-linked_GlycosylationELPWIHCNNSWNSPN
CCCEEECCCCCCCCC		31.2612429746
188N-linked_GlycosylationNNSWNSPNCSDAHPG
CCCCCCCCCCCCCCC		37.4312429746
188N-linked_GlycosylationNNSWNSPNCSDAHPG
CCCCCCCCCCCCCCC		37.4312429746
205N-linked_GlycosylationSGDSSGLNDTFGTTP
CCCCCCCCCCCCCCC		50.2112429746
205N-linked_GlycosylationSGDSSGLNDTFGTTP
CCCCCCCCCCCCCCC		50.2112429746
261PhosphorylationSLWKGVKTSGKVVWI
HHHCCCCCCCCEEEE		40.0616740633
262PhosphorylationLWKGVKTSGKVVWIT
HHCCCCCCCCEEEEE		30.7922210691
269PhosphorylationSGKVVWITATMPYVV
CCCEEEEECCHHHHH		10.6022210691
271PhosphorylationKVVWITATMPYVVLT
CEEEEECCHHHHHHH		15.2722210691
278PhosphorylationTMPYVVLTALLLRGV
CHHHHHHHHHHHCCC		12.03-
286PhosphorylationALLLRGVTLPGAIDG
HHHHCCCCCCCCHHH		30.02-
593PhosphorylationSFREKLAYAIAPEKD
CHHHHHHHHHCCCCC		14.69-
613PhosphorylationRGEVRQFTLRHWLKV
HHHHHHHHHHHHHCC		17.9724719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
2SPhosphorylationKinaseCAMK2AP11798
PSP
4SPhosphorylationKinaseCAMK2AP11798
PSP
7SPhosphorylationKinaseCAMK2AP11798
PSP
7SPhosphorylationKinasePRKCAP17252
GPS
12SPhosphorylationKinaseCAMK2AP11798
PSP
12SPhosphorylationKinasePRKCAP17252
GPS
13SPhosphorylationKinaseCAMK2AP11798
PSP
-KUbiquitinationE3 ubiquitin ligaseNEDD4P46934
PMID:20051513
-KUbiquitinationE3 ubiquitin ligaseNEDD4LQ96PU5
PMID:16885233
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SC6A3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SC6A3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SYUA_HUMANSNCAphysical
12672538
TGFI1_HUMANTGFB1I1physical
12177201
TGFI1_MOUSETgfb1i1physical
12177201
PICK1_HUMANPICK1physical
11343649
SYUA_HUMANSNCAphysical
11292651
NEDD4_HUMANNEDD4physical
16885233
EPS15_HUMANEPS15physical
16885233
EPN1_HUMANEPN1physical
16885233
STX1A_HUMANSTX1Aphysical
18617632
SYUA_HUMANSNCAphysical
14550771
SYUA_HUMANSNCAphysical
14756560
SYUA_HUMANSNCAphysical
16216085
TBA1B_HUMANTUBA1Bphysical
16216085
TBB1_HUMANTUBB1physical
16216085
STX1A_HUMANSTX1Aphysical
25774383
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
613135Parkinsonism-dystonia infantile (PKDYS)
Kegg Drug
D00110 Cocaine (USP); Cocaine (TN)
D00367 Mazindol (JAN/USP/INN); Sanorex (TN)
D02074 Amphetamine sulfate (USP); Benzedrine (TN)
D02078 Dextroamphetamine sulfate (USP); Dexedrine (TN); Dextrostat (TN)
D02182 Cocaine hydrochloride (JP16/USP); Cocaine hydrochloride (TN)
D02242 Methamphetamine hydrochloride (JP16/USP); Desoxyn (TN)
D02571 Sibutramine hydrochloride hydrate (JAN); Sibutramine hydrochloride (USAN); Sibutramine hydrochloride
D02897 Amfonelic acid (USAN); Acidum amfonelicum (INN)
D03110 Bicifadine hydrochloride (USAN)
D03713 Dexfenfluramine hydrochloride (USAN); d-Fenfluramine hydrochloride; Redux (TN)
D03740 Dextroamphetamine (USAN); Dexamfetamine (INN)
D04747 Lisdexamfetamine dimesylate (USAN); Vyvanse (TN); Elvanse (TN)
D05663 Pyrovalerone hydrochloride (USAN)
D07445 Amfetamine (INN); Amphetamine; Amfetamin (TN)
D07805 Dexfenfluramine (INN)
D08130 Lisdexamfetamine (INN)
D08187 Metamfetamine (INN); Methamphetamine
D08513 Sibutramine (INN); Butramin (TN)
D10014 Ioflupane I 123 (USAN); Datscan (TN)
D10088 Amitifadine (USAN)
D10089 Amitifadine hydrochloride (USAN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SC6A3_HUMAN

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Related Literatures of Post-Translational Modification

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