dbPTM

TGFI1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TGFI1_MOUSE
UniProt AC	Q62219
Protein Name	Transforming growth factor beta-1-induced transcript 1 protein
Gene Name	Tgfb1i1
Organism	Mus musculus (Mouse).
Sequence Length	461
Subcellular Localization	Cell junction, focal adhesion. Nucleus matrix. Cytoplasm, cytoskeleton. Associated with the actin cytoskeleton, colocalizes with stress fibers.
Protein Description	Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity..
Protein Sequence	MEDLDALLSDLETTTSHMSRLGAPKERPPETLTPPPPYGHQPQTGSGESSGTTGDKDHLYSTVCKPRSPKPVAPVAPPFSSSSGVLGNGLCELDRLLQELNATQFNITDEIMSQFPSSKMAEGEEKEDQSEDKSSPTVPPSPFPAPSKPSATSATQELDRLMASLSDFRVQNHLPASGPPQPPAASPTREGCPSPPGQTSKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVVTALGRAWHPEHFLCSGCSTTLGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGEEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECLAPFSGGSFFEHEGRPLCENHFHAQRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERASKPYCQPCFLKLFG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEDLDALL -------CHHHHHHH	9.02	-
2 (in isoform 2)	Phosphorylation	-	68.25	25266776
2 (in isoform 7)	Phosphorylation	-	68.25	25266776
2 (in isoform 8)	Phosphorylation	-	68.25	25266776
3 (in isoform 5)	Phosphorylation	-	48.85	30635358
4 (in isoform 5)	Phosphorylation	-	2.36	30635358
7 (in isoform 7)	Phosphorylation	-	4.73	25266776
9	Phosphorylation	EDLDALLSDLETTTS HHHHHHHHHHHHHHH	40.79	23649490
18 (in isoform 5)	Phosphorylation	-	2.21	30635358
19	Phosphorylation	ETTTSHMSRLGAPKE HHHHHHHHHCCCCCC	20.94	25266776
31	Phosphorylation	PKERPPETLTPPPPY CCCCCCCCCCCCCCC	41.53	26824392
33	Phosphorylation	ERPPETLTPPPPYGH CCCCCCCCCCCCCCC	40.96	30352176
38	Phosphorylation	TLTPPPPYGHQPQTG CCCCCCCCCCCCCCC	32.77	16183059
44	Phosphorylation	PYGHQPQTGSGESSG CCCCCCCCCCCCCCC	39.74	-
52	Phosphorylation	GSGESSGTTGDKDHL CCCCCCCCCCCCCCE	29.56	22871156
60	Phosphorylation	TGDKDHLYSTVCKPR CCCCCCEEEEECCCC	10.01	26824392
61	Phosphorylation	GDKDHLYSTVCKPRS CCCCCEEEEECCCCC	22.26	18515860
68	Phosphorylation	STVCKPRSPKPVAPV EEECCCCCCCCCCCC	45.89	26824392
80	Phosphorylation	APVAPPFSSSSGVLG CCCCCCCCCCCCCCC	34.78	25777480
81	Phosphorylation	PVAPPFSSSSGVLGN CCCCCCCCCCCCCCC	28.98	29550500
82	Phosphorylation	VAPPFSSSSGVLGNG CCCCCCCCCCCCCCH	29.88	29550500
83	Phosphorylation	APPFSSSSGVLGNGL CCCCCCCCCCCCCHH	34.56	26824392
113	Phosphorylation	NITDEIMSQFPSSKM CCCHHHHHHCCCHHC	34.04	25266776
118	Phosphorylation	IMSQFPSSKMAEGEE HHHHCCCHHCCCCCC	27.04	25266776
130	Phosphorylation	GEEKEDQSEDKSSPT CCCCCCCCCCCCCCC	61.15	26824392
134	Phosphorylation	EDQSEDKSSPTVPPS CCCCCCCCCCCCCCC	54.60	29472430
135	Phosphorylation	DQSEDKSSPTVPPSP CCCCCCCCCCCCCCC	30.26	29472430
137	Phosphorylation	SEDKSSPTVPPSPFP CCCCCCCCCCCCCCC	47.82	25777480
141	Phosphorylation	SSPTVPPSPFPAPSK CCCCCCCCCCCCCCC	32.86	27180971
147	Phosphorylation	PSPFPAPSKPSATSA CCCCCCCCCCCCCCH	60.34	25777480
150	Phosphorylation	FPAPSKPSATSATQE CCCCCCCCCCCHHHH	48.17	25777480
152	Phosphorylation	APSKPSATSATQELD CCCCCCCCCHHHHHH	24.19	25777480
153	Phosphorylation	PSKPSATSATQELDR CCCCCCCCHHHHHHH	29.09	25777480
155	Phosphorylation	KPSATSATQELDRLM CCCCCCHHHHHHHHH	23.49	25777480
164	Phosphorylation	ELDRLMASLSDFRVQ HHHHHHHHHHHCCHH	17.91	27180971
166	Phosphorylation	DRLMASLSDFRVQNH HHHHHHHHHCCHHHC	32.01	21082442
177	Phosphorylation	VQNHLPASGPPQPPA HHHCCCCCCCCCCCC	50.31	25619855
186	Phosphorylation	PPQPPAASPTREGCP CCCCCCCCCCCCCCC	28.98	25521595
188	Phosphorylation	QPPAASPTREGCPSP CCCCCCCCCCCCCCC	38.57	26824392
194	Phosphorylation	PTREGCPSPPGQTSK CCCCCCCCCCCCCCC	48.04	25521595
199	Phosphorylation	CPSPPGQTSKGSLDT CCCCCCCCCCCCHHH	38.02	21659605
200	Phosphorylation	PSPPGQTSKGSLDTM CCCCCCCCCCCHHHH	27.42	21659605
203	Phosphorylation	PGQTSKGSLDTMLGL CCCCCCCCHHHHHHH	27.15	27180971
206	Phosphorylation	TSKGSLDTMLGLLQS CCCCCHHHHHHHHHH	21.42	29472430
403	Phosphorylation	HFHAQRGSLCATCGL CCCCCCCCCHHHCCC	23.59	25521595
407	Phosphorylation	QRGSLCATCGLPVTG CCCCCHHHCCCCCCC	13.20	27742792
418	Phosphorylation	PVTGRCVSALGRRFH CCCCCHHHHHCCCCC	22.77	22817900
439	Phosphorylation	TFCLRPLTKGSFQER EEECCCCCCCCHHHH	35.72	26824392
448	Phosphorylation	GSFQERASKPYCQPC CCHHHHCCCCCCCCH	40.14	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
141	S	Phosphorylation	Kinase	MAPK1	P63085	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TGFI1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TGFI1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FAK1_HUMAN	PTK2	physical	9756887
GIT1_MOUSE	Git1	physical	12153727
TLX3_MOUSE	Tlx3	physical	20211142
SMAD3_MOUSE	Smad3	physical	14755691

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TGFI1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Tyrosine-phosphorylated Hic-5 inhibits epidermal growth factor-induced lamellipodia formation."; Hetey S.E., Lalonde D.P., Turner C.E.; Exp. Cell Res. 311:147-156(2005). Cited for: FUNCTION, MUTAGENESIS OF TYR-38; TYR-60; CYS-369 AND CYS-372,SUBCELLULAR LOCATION, AND PHOSPHORYLATION AT TYR-38 AND TYR-60.	16183059 [Abstract]