LAP4A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LAP4A_HUMAN
• UniProt AC: Q15012
• Protein Name: Lysosomal-associated transmembrane protein 4A
• Gene Name: LAPTM4A
• Organism: Homo sapiens (Human).
• Sequence Length: 233
• Subcellular Localization: Endomembrane system ; Multi-pass membrane protein . May reside in an intracellular membrane-bound compartment.
• Protein Description: May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment..
• Protein Sequence: MVSMSFKRNRSDRFYSTRCCGCCHVRTGTIILGTWYMVVNLLMAILLTVEVTHPNSMPAVNIQYEVIGNYYSSERMADNACVLFAVSVLMFIISSMLVYGAISYQVGWLIPFFCYRLFDFVLSCLVAISSLTYLPRIKEYLDQLPDFPYKDDLLALDSSCLLFIVLVFFALFIIFKAYLINCVWNCYKYINNRNVPEIAVYPAFEAPPQYVLPTYEMAVKMPEKEPPPPYLPA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MVSMSFKR -------CCCCCCCC	4.55	25732826
3	Phosphorylation	-----MVSMSFKRNR -----CCCCCCCCCC	13.86	26434776
5	Phosphorylation	---MVSMSFKRNRSD ---CCCCCCCCCCCC	21.80	30108239
7	2-Hydroxyisobutyrylation	-MVSMSFKRNRSDRF -CCCCCCCCCCCCCC	41.26	-
7	Ubiquitination	-MVSMSFKRNRSDRF -CCCCCCCCCCCCCC	41.26	21890473
11	Phosphorylation	MSFKRNRSDRFYSTR CCCCCCCCCCCEECC	36.37	24275569
19	S-palmitoylation	DRFYSTRCCGCCHVR CCCEECCCCCCCCCC	2.07	29575903
20	S-palmitoylation	RFYSTRCCGCCHVRT CCEECCCCCCCCCCC	4.16	29575903
22	S-palmitoylation	YSTRCCGCCHVRTGT EECCCCCCCCCCCCC	0.63	29575903
23	S-palmitoylation	STRCCGCCHVRTGTI ECCCCCCCCCCCCCE	1.70	29575903
140	Phosphorylation	YLPRIKEYLDQLPDF CHHHHHHHHHCCCCC	15.58	-
210	Phosphorylation	AFEAPPQYVLPTYEM CCCCCCCCEECCHHH	15.10	26356563
214	Phosphorylation	PPQYVLPTYEMAVKM CCCCEECCHHHHCCC	28.14	26356563
215	Phosphorylation	PQYVLPTYEMAVKMP CCCEECCHHHHCCCC	11.19	27259358
220	Ubiquitination	PTYEMAVKMPEKEPP CCHHHHCCCCCCCCC	38.92	21906983
224	Ubiquitination	MAVKMPEKEPPPPYL HHCCCCCCCCCCCCC	70.43	20972266
230	Phosphorylation	EKEPPPPYLPA---- CCCCCCCCCCC----	30.96	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LAP4A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LAP4A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LAP4A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TFR1_HUMAN	TFRC	physical	22096579

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells.";
Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.;
J. Proteome Res. 8:3852-3861(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-230, AND MASSSPECTROMETRY.
PubMed: 19534553

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-230, AND MASSSPECTROMETRY.
PubMed: 18083107