dbPTM

HMGN2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HMGN2_HUMAN
UniProt AC	P05204
Protein Name	Non-histone chromosomal protein HMG-17
Gene Name	HMGN2
Organism	Homo sapiens (Human).
Sequence Length	90
Subcellular Localization	Nucleus . Cytoplasm . Cytoplasmic enrichment upon phosphorylation.
Protein Description	Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity)..
Protein Sequence	MPKRKAEGDAKGDKAKVKDEPQRRSARLSAKPAPPKPEPKPKKAPAKKGEKVPKGKKGKADAGKEGNNPAENGDAKTDQAQKAEGAGDAK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Acetylation	-----MPKRKAEGDA -----CCCCCCCCCC	66.29	10207070
5	Acetylation	---MPKRKAEGDAKG ---CCCCCCCCCCCC	57.84	59699
11	Acetylation	RKAEGDAKGDKAKVK CCCCCCCCCCHHHCC	72.83	59703
14	Acetylation	EGDAKGDKAKVKDEP CCCCCCCHHHCCCCH	59.79	70015
14	Ubiquitination	EGDAKGDKAKVKDEP CCCCCCCHHHCCCCH	59.79	24816145
18	Acetylation	KGDKAKVKDEPQRRS CCCHHHCCCCHHHHH	56.52	10753971
18	Sumoylation	KGDKAKVKDEPQRRS CCCHHHCCCCHHHHH	56.52	-
18	Ubiquitination	KGDKAKVKDEPQRRS CCCHHHCCCCHHHHH	56.52	33845483
18	Sumoylation	KGDKAKVKDEPQRRS CCCHHHCCCCHHHHH	56.52	10753971
25	Phosphorylation	KDEPQRRSARLSAKP CCCHHHHHHHHCCCC	21.67	25159151
29	ADP-ribosylation	QRRSARLSAKPAPPK HHHHHHHCCCCCCCC	28.79	28190768
29	Phosphorylation	QRRSARLSAKPAPPK HHHHHHHCCCCCCCC	28.79	23401153
31	Acetylation	RSARLSAKPAPPKPE HHHHHCCCCCCCCCC	38.03	19608861
31	Ubiquitination	RSARLSAKPAPPKPE HHHHHCCCCCCCCCC	38.03	23000965
36	Ubiquitination	SAKPAPPKPEPKPKK CCCCCCCCCCCCCCC	62.04	23000965
36	Sumoylation	SAKPAPPKPEPKPKK CCCCCCCCCCCCCCC	62.04	19608861
36	Acetylation	SAKPAPPKPEPKPKK CCCCCCCCCCCCCCC	62.04	23954790
36	Sumoylation	SAKPAPPKPEPKPKK CCCCCCCCCCCCCCC	62.04	-
40	Acetylation	APPKPEPKPKKAPAK CCCCCCCCCCCCCCC	68.74	23749302
40	Ubiquitination	APPKPEPKPKKAPAK CCCCCCCCCCCCCCC	68.74	29967540
42	Acetylation	PKPEPKPKKAPAKKG CCCCCCCCCCCCCCC	68.63	10753971
47	Ubiquitination	KPKKAPAKKGEKVPK CCCCCCCCCCCCCCC	61.32	-
48	Ubiquitination	PKKAPAKKGEKVPKG CCCCCCCCCCCCCCC	74.53	-
48	Acetylation	PKKAPAKKGEKVPKG CCCCCCCCCCCCCCC	74.53	10753971
51	Ubiquitination	APAKKGEKVPKGKKG CCCCCCCCCCCCCCC	72.93	-
54	Acetylation	KKGEKVPKGKKGKAD CCCCCCCCCCCCCCC	83.07	88049
56	Acetylation	GEKVPKGKKGKADAG CCCCCCCCCCCCCCC	65.56	88053
57	Acetylation	EKVPKGKKGKADAGK CCCCCCCCCCCCCCC	74.45	129283
59	Acetylation	VPKGKKGKADAGKEG CCCCCCCCCCCCCCC	52.55	21339330
59	Ubiquitination	VPKGKKGKADAGKEG CCCCCCCCCCCCCCC	52.55	22817900
64	Ubiquitination	KGKADAGKEGNNPAE CCCCCCCCCCCCCCC	65.26	21906983
64	Acetylation	KGKADAGKEGNNPAE CCCCCCCCCCCCCCC	65.26	23749302
76	Acetylation	PAENGDAKTDQAQKA CCCCCCCCHHHHHHH	58.33	23749302
76	Ubiquitination	PAENGDAKTDQAQKA CCCCCCCCHHHHHHH	58.33	21906983
82	Acetylation	AKTDQAQKAEGAGDA CCHHHHHHHCCCCCC	51.96	19608861
82	Sumoylation	AKTDQAQKAEGAGDA CCHHHHHHHCCCCCC	51.96	-
82	Ubiquitination	AKTDQAQKAEGAGDA CCHHHHHHHCCCCCC	51.96	27667366
82	Sumoylation	AKTDQAQKAEGAGDA CCHHHHHHHCCCCCC	51.96	25218447
90	Acetylation	AEGAGDAK------- HCCCCCCC-------	66.66	70023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
25	S	Phosphorylation	Kinase	AURKB	Q96GD4	GPS
29	S	Phosphorylation	Kinase	AURKB	Q96GD4	GPS
29	S	Phosphorylation	Kinase	PKG-FAMILY	-	GPS
29	S	Phosphorylation	Kinase	PKG/CGK_GROUP	-	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HMGN2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HMGN2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HMGN2_HUMAN	HMGN2	physical	7563062
POL_HV1H2	gag-pol	physical	20016921
KLH36_HUMAN	KLHL36	physical	28514442
PARP2_HUMAN	PARP2	physical	28514442
CHM1A_HUMAN	CHMP1A	physical	28514442
H2AY_HUMAN	H2AFY	physical	28514442
PYGB_HUMAN	PYGB	physical	28514442
GLGB_HUMAN	GBE1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HMGN2_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-82, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Phosphorylation and subcellular redistribution of high mobility groupproteins 14 and 17, analyzed by mass spectrometry."; Louie D.F., Gloor K.K., Galasinski S.C., Resing K.A., Ahn N.G.; Protein Sci. 9:170-179(2000). Cited for: PROTEIN SEQUENCE OF 19-31, PHOSPHORYLATION AT SER-25 AND SER-29,SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.	10739259 [Abstract]