dbPTM

ZEP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZEP2_HUMAN
UniProt AC	P31629
Protein Name	Transcription factor HIVEP2
Gene Name	HIVEP2
Organism	Homo sapiens (Human).
Sequence Length	2446
Subcellular Localization	Nucleus.
Protein Description	This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation..
Protein Sequence	MDTGDTALGQKATSRSGETDKASGRWRQEQSAVIKMSTFGSHEGQRQPQIEPEQIGNTASAQLFGSGKLASPSEVVQQVAEKQYPPHRPSPYSCQHSLSFPQHSLPQGVMHSTKPHQSLEGPPWLFPGPLPSVASEDLFPFPIHGHSGGYPRKKISSLNPAYSQYSQKSIEQAEEAHKKEHKPKKPGKYICPYCSRACAKPSVLKKHIRSHTGERPYPCIPCGFSFKTKSNLYKHRKSHAHAIKAGLVPFTESAVSKLDLEAGFIDVEAEIHSDGEQSTDTDEESSLFAEASDKMSPGPPIPLDIASRGGYHGSLEESLGGPMKVPILIIPKSGIPLPNESSQYIGPDMLPNPSLNTKADDSHTVKQKLALRLSEKKGQDSEPSLNLLSPHSKGSTDSGYFSRSESAEQQISPPNTNAKSYEEIIFGKYCRLSPRNALSVTTTSQERAAMGRKGIMEPLPHVNTRLDVKMFEDPVSQLIPSKGDVDPSQTSMLKSTKFNSESRQPQIIPSSIRNEGKLYPANFQGSNPVLLEAPVDSSPLIRSNSVPTSSATNLTIPPSLRGSHSFDERMTGSDDVFYPGTVGIPPQRMLRRQAAFELPSVQEGHVEVEHHGRMLKGISSSSLKEKKLSPGDRVGYDYDVCRKPYKKWEDSETPKQNYRDISCLSSLKHGGEYFMDPVVPLQGVPSMFGTTCENRKRRKEKSVGDEEDTPMICSSIVSTPVGIMASDYDPKLQMQEGVRSGFAMAGHENLSHGHTERFDPCRPQLQPGSPSLVSEESPSAIDSDKMSDLGGRKPPGNVISVIQHTNSLSRPNSFERSESAELVACTQDKAPSPSETCDSEISEAPVSPEWAPPGDGAESGGKPSPSQQVQQQSYHTQPRLVRQHNIQVPEIRVTEEPDKPEKEKEAQSKEPEKPVEEFQWPQRSETLSQLPAEKLPPKKKRLRLADMEHSSGESSFESTGTGLSRSPSQESNLSHSSSFSMSFEREETSKLSALPKQDEFGKHSEFLTVPAGSYSLSVPGHHHQKEMRRCSSEQMPCPHPAEVPEVRSKSFDYGNLSHAPVSGAAASTVSPSRERKKCFLVRQASFSGSPEISQGEVGMDQSVKQEQLEHLHAGLRSGWHHGPPAVLPPLQQEDPGKQVAGPCPPLSSGPLHLAQPQIMHMDSQESLRNPLIQPTSYMTSKHLPEQPHLFPHQETIPFSPIQNALFQFQYPTVCMVHLPAQQPPWWQAHFPHPFAQHPQKSYGKPSFQTEIHSSYPLEHVAEHTGKKPAEYAHTKEQTYPCYSGASGLHPKNLLPKFPSDQSSKSTETPSEQVLQEDFASANAGSLQSLPGTVVPVRIQTHVPSYGSVMYTSISQILGQNSPAIVICKVDENMTQRTLVTNAAMQGIGFNIAQVLGQHAGLEKYPIWKAPQTLPLGLESSIPLCLPSTSDSVATLGGSKRMLSPASSLELFMETKQQKRVKEEKMYGQIVEELSAVELTNSDIKKDLSRPQKPQLVRQGCASEPKDGLQSGSSSFSSLSPSSSQDYPSVSPSSREPFLPSKEMLSGSRAPLPGQKSSGPSESKESSDELDIDETASDMSMSPQSSSLPAGDGQLEEEGKGHKRPVGMLVRMASAPSGNVADSTLLLTDMADFQQILQFPSLRTTTTVSWCFLNYTKPNYVQQATFKSSVYASWCISSCNPNPSGLNTKTTLALLRSKQKITAEIYTLAAMHRPGTGKLTSSSAWKQFTQMKPDASFLFGSKLERKLVGNILKERGKGDIHGDKDIGSKQTEPIRIKIFEGGYKSNEDYVYVRGRGRGKYICEECGIRCKKPSMLKKHIRTHTDVRPYVCKLCNFAFKTKGNLTKHMKSKAHMKKCLELGVSMTSVDDTETEEAENLEDLHKAAEKHSMSSISTDHQFSDAEESDGEDGDDNDDDDEDEDDFDDQGDLTPKTRSRSTSPQPPRFSSLPVNVGAVPHGVPSDSSLGHSSLISYLVTLPSIRVTQLMTPSDSCEDTQMTEYQRLFQSKSTDSEPDKDRLDIPSCMDEECMLPSEPSSSPRDFSPSSHHSSPGYDSSPCRDNSPKRYLIPKGDLSPRRHLSPRRDLSPMRHLSPRKEAALRREMSQRDVSPRRHLSPRRPVSPGKDITARRDLSPRRERRYMTTIRAPSPRRALYHNPPLSMGQYLQAEPIVLGPPNLRRGLPQVPYFSLYGDQEGAYEHPGSSLFPEGPNDYVFSHLPLHSQQQVRAPIPMVPVGGIQMVHSMPPALSSLHPSPTLPLPMEGFEEKKGASGESFSKDPYVLSKQHEKRGPHALQSSGPPSTPSSPRLLMKQSTSEDSLNATEREQEENIQTCTKAIASLRIATEEAALLGPDQPARVQEPHQNPLGSAHVSIRHFSRPEPGQPCTSATHPDLHDGEKDNFGTSQTPLAHSTFYSKSCVDDKQLDFHSSKELSSSTEESKDPSSEKSQLH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	SAVIKMSTFGSHEGQ CEEEEEHHCCCCCCC	28.63	27251275
41	Phosphorylation	IKMSTFGSHEGQRQP EEEHHCCCCCCCCCC	17.74	25159151
71	Phosphorylation	FGSGKLASPSEVVQQ HCCCCCCCHHHHHHH	39.12	30266825
73	Phosphorylation	SGKLASPSEVVQQVA CCCCCCHHHHHHHHH	40.29	30266825
154	Ubiquitination	SGGYPRKKISSLNPA CCCCCCHHHHHCCHH	49.45	29967540
156	Phosphorylation	GYPRKKISSLNPAYS CCCCHHHHHCCHHHH	37.34	25002506
157	Phosphorylation	YPRKKISSLNPAYSQ CCCHHHHHCCHHHHH	35.32	25002506
162	Phosphorylation	ISSLNPAYSQYSQKS HHHCCHHHHHHCHHH	9.51	28348404
163	O-linked_Glycosylation	SSLNPAYSQYSQKSI HHCCHHHHHHCHHHH	25.42	31492838
163	Phosphorylation	SSLNPAYSQYSQKSI HHCCHHHHHHCHHHH	25.42	23401153
165	Phosphorylation	LNPAYSQYSQKSIEQ CCHHHHHHCHHHHHH	13.71	25002506
166	Phosphorylation	NPAYSQYSQKSIEQA CHHHHHHCHHHHHHH	24.40	23927012
168	Ubiquitination	AYSQYSQKSIEQAEE HHHHHCHHHHHHHHH	47.67	29967540
169	Phosphorylation	YSQYSQKSIEQAEEA HHHHCHHHHHHHHHH	24.58	23401153
178	Ubiquitination	EQAEEAHKKEHKPKK HHHHHHHHHHCCCCC	67.89	21906983
179	Acetylation	QAEEAHKKEHKPKKP HHHHHHHHHCCCCCC	56.00	18530393
179	Ubiquitination	QAEEAHKKEHKPKKP HHHHHHHHHCCCCCC	56.00	22817900
182	Ubiquitination	EAHKKEHKPKKPGKY HHHHHHCCCCCCCCC	60.67	22817900
189	Phosphorylation	KPKKPGKYICPYCSR CCCCCCCCCCCCCHH	17.42	-
193	Phosphorylation	PGKYICPYCSRACAK CCCCCCCCCHHHCCC	9.92	-
195	Phosphorylation	KYICPYCSRACAKPS CCCCCCCHHHCCCHH	19.64	-
212	Phosphorylation	KKHIRSHTGERPYPC HHHHHHCCCCCCCCC	41.82	28555341
225	Phosphorylation	PCIPCGFSFKTKSNL CCCCCCCEEECCCHH	15.89	24719451
251	O-linked_Glycosylation	KAGLVPFTESAVSKL HCCCCCCCHHHHHHC	23.98	31492838
285	Phosphorylation	STDTDEESSLFAEAS CCCCHHHHHHHHHHH	30.23	22210691
286	Phosphorylation	TDTDEESSLFAEASD CCCHHHHHHHHHHHH	30.68	22210691
296	Phosphorylation	AEASDKMSPGPPIPL HHHHHCCCCCCCCCC	32.23	29255136
311	Phosphorylation	DIASRGGYHGSLEES CHHHCCCCCCCHHHH	13.06	22777824
314	Phosphorylation	SRGGYHGSLEESLGG HCCCCCCCHHHHCCC	21.21	22777824
318	Phosphorylation	YHGSLEESLGGPMKV CCCCHHHHCCCCCCC	23.96	23090842
332	Ubiquitination	VPILIIPKSGIPLPN CCEEEECCCCCCCCC	51.40	21906983
358	Ubiquitination	PNPSLNTKADDSHTV CCCCCCCCCCCCHHH	49.06	21906983
366	Ubiquitination	ADDSHTVKQKLALRL CCCCHHHHHHHHHHH	42.76	21906983
368	Ubiquitination	DSHTVKQKLALRLSE CCHHHHHHHHHHHHH	29.97	22817900
374	Phosphorylation	QKLALRLSEKKGQDS HHHHHHHHHHCCCCC	40.72	25159151
381	Phosphorylation	SEKKGQDSEPSLNLL HHHCCCCCCCCCCCC	43.44	27251275
384	O-linked_Glycosylation	KGQDSEPSLNLLSPH CCCCCCCCCCCCCCC	26.32	31492838
389	Phosphorylation	EPSLNLLSPHSKGST CCCCCCCCCCCCCCC	24.59	25159151
392	O-linked_Glycosylation	LNLLSPHSKGSTDSG CCCCCCCCCCCCCCC	41.94	31492838
392	Phosphorylation	LNLLSPHSKGSTDSG CCCCCCCCCCCCCCC	41.94	27251275
402	Phosphorylation	STDSGYFSRSESAEQ CCCCCCCCCCCCHHH	26.81	-
404	Phosphorylation	DSGYFSRSESAEQQI CCCCCCCCCCHHHCC	34.40	23312004
406	Phosphorylation	GYFSRSESAEQQISP CCCCCCCCHHHCCCC	38.05	23312004
412	Phosphorylation	ESAEQQISPPNTNAK CCHHHCCCCCCCCCC	29.93	25850435
416	Phosphorylation	QQISPPNTNAKSYEE HCCCCCCCCCCCHHH	42.18	27794612
420	O-linked_Glycosylation	PPNTNAKSYEEIIFG CCCCCCCCHHHHHHC	35.05	31492838
420	Phosphorylation	PPNTNAKSYEEIIFG CCCCCCCCHHHHHHC	35.05	28796482
421	Phosphorylation	PNTNAKSYEEIIFGK CCCCCCCHHHHHHCC	19.51	28796482
428	Ubiquitination	YEEIIFGKYCRLSPR HHHHHHCCCCCCCCC	30.35	21906983
433	Phosphorylation	FGKYCRLSPRNALSV HCCCCCCCCCCCCCC	11.49	24719451
439	Phosphorylation	LSPRNALSVTTTSQE CCCCCCCCCCCCHHH	18.27	28348404
441	O-linked_Glycosylation	PRNALSVTTTSQERA CCCCCCCCCCHHHHH	22.45	31492838
441	Phosphorylation	PRNALSVTTTSQERA CCCCCCCCCCHHHHH	22.45	28348404
442	O-linked_Glycosylation	RNALSVTTTSQERAA CCCCCCCCCHHHHHH	23.46	31492838
442	Phosphorylation	RNALSVTTTSQERAA CCCCCCCCCHHHHHH	23.46	20639409
443	O-linked_Glycosylation	NALSVTTTSQERAAM CCCCCCCCHHHHHHC	21.03	31492838
443	Phosphorylation	NALSVTTTSQERAAM CCCCCCCCHHHHHHC	21.03	20639409
444	Phosphorylation	ALSVTTTSQERAAMG CCCCCCCHHHHHHCC	28.14	25159151
453	Ubiquitination	ERAAMGRKGIMEPLP HHHHCCCCCCCCCCC	47.24	22817900
464	Phosphorylation	EPLPHVNTRLDVKMF CCCCCCCCCCCCEEE	31.36	29632367
469	Ubiquitination	VNTRLDVKMFEDPVS CCCCCCCEEECCCHH	37.22	21906983
481	Phosphorylation	PVSQLIPSKGDVDPS CHHHHCCCCCCCCHH	42.13	24719451
482	Ubiquitination	VSQLIPSKGDVDPSQ HHHHCCCCCCCCHHH	54.50	22817900
494	Ubiquitination	PSQTSMLKSTKFNSE HHHHHHHHHCCCCCC	47.65	33845483
500	O-linked_Glycosylation	LKSTKFNSESRQPQI HHHCCCCCCCCCCCC	39.83	31492838
500	Phosphorylation	LKSTKFNSESRQPQI HHHCCCCCCCCCCCC	39.83	28555341
511	O-linked_Glycosylation	QPQIIPSSIRNEGKL CCCCCCHHHCCCCCE	21.88	31492838
517	Ubiquitination	SSIRNEGKLYPANFQ HHHCCCCCEECCCCC	38.37	21906983
526	Phosphorylation	YPANFQGSNPVLLEA ECCCCCCCCCEEEEC	27.46	24719451
538	Phosphorylation	LEAPVDSSPLIRSNS EECCCCCCCCCCCCC	21.18	24719451
548	Phosphorylation	IRSNSVPTSSATNLT CCCCCCCCCCCCCCC	32.91	-
552	Phosphorylation	SVPTSSATNLTIPPS CCCCCCCCCCCCCHH	32.48	-
563	Phosphorylation	IPPSLRGSHSFDERM CCHHHCCCCCCCCCC	14.99	28355574
565	Phosphorylation	PSLRGSHSFDERMTG HHHCCCCCCCCCCCC	35.77	23401153
616	Methylation	EHHGRMLKGISSSSL ECCCEECCCCCCHHH	44.87	115970663
619	Phosphorylation	GRMLKGISSSSLKEK CEECCCCCCHHHCCC	32.60	23401153
620	Phosphorylation	RMLKGISSSSLKEKK EECCCCCCHHHCCCC	23.25	22985185
621	Phosphorylation	MLKGISSSSLKEKKL ECCCCCCHHHCCCCC	32.66	20363803
622	Phosphorylation	LKGISSSSLKEKKLS CCCCCCHHHCCCCCC	45.46	28857561
624	Methylation	GISSSSLKEKKLSPG CCCCHHHCCCCCCCC	70.23	115970671
626	Methylation	SSSSLKEKKLSPGDR CCHHHCCCCCCCCCC	58.38	115970679
629	Phosphorylation	SLKEKKLSPGDRVGY HHCCCCCCCCCCCCC	35.40	27422710
638	Phosphorylation	GDRVGYDYDVCRKPY CCCCCCCHHHCCCCC	11.20	22817900
645	Phosphorylation	YDVCRKPYKKWEDSE HHHCCCCCCCCCCCC	28.38	29083192
655	Ubiquitination	WEDSETPKQNYRDIS CCCCCCCCCCCCHHH	59.60	21906983
665	Phosphorylation	YRDISCLSSLKHGGE CCHHHHHHHCCCCCC	37.64	24719451
702	Phosphorylation	RKRRKEKSVGDEEDT CHHHHHCCCCCCCCC	32.21	28348404
751	Phosphorylation	MAGHENLSHGHTERF HCCCCCCCCCCCCCC	38.72	28555341
769	Phosphorylation	RPQLQPGSPSLVSEE CCCCCCCCCCCCCCC	20.28	22617229
771	Phosphorylation	QLQPGSPSLVSEESP CCCCCCCCCCCCCCC	43.00	25850435
774	Phosphorylation	PGSPSLVSEESPSAI CCCCCCCCCCCCCCC	40.72	25850435
777	Phosphorylation	PSLVSEESPSAIDSD CCCCCCCCCCCCCCC	21.80	26074081
779	Phosphorylation	LVSEESPSAIDSDKM CCCCCCCCCCCCCHH	47.32	26074081
800	Phosphorylation	KPPGNVISVIQHTNS CCCCCCEEEEECCCC	14.64	20873877
805	Phosphorylation	VISVIQHTNSLSRPN CEEEEECCCCCCCCC	15.32	20873877
807	Phosphorylation	SVIQHTNSLSRPNSF EEEECCCCCCCCCCC	28.95	25849741
809	Phosphorylation	IQHTNSLSRPNSFER EECCCCCCCCCCCCC	45.58	20873877
813	Phosphorylation	NSLSRPNSFERSESA CCCCCCCCCCCCCCC	31.03	25849741
817	Phosphorylation	RPNSFERSESAELVA CCCCCCCCCCCEEEE	28.80	25850435
819	Phosphorylation	NSFERSESAELVACT CCCCCCCCCEEEEEC	28.43	25849741
826	Phosphorylation	SAELVACTQDKAPSP CCEEEEECCCCCCCC	30.02	27251275
864	Phosphorylation	AESGGKPSPSQQVQQ CCCCCCCCHHHHHHH	40.44	30619164
866	Phosphorylation	SGGKPSPSQQVQQQS CCCCCCHHHHHHHHH	37.27	30619164
924	O-linked_Glycosylation	EFQWPQRSETLSQLP HCCCCCCCCCHHHCC	29.68	31492838
924	Phosphorylation	EFQWPQRSETLSQLP HCCCCCCCCCHHHCC	29.68	26437602
926	Phosphorylation	QWPQRSETLSQLPAE CCCCCCCCHHHCCHH	32.72	23684312
928	Phosphorylation	PQRSETLSQLPAEKL CCCCCCHHHCCHHHC	36.77	23312004
950	Phosphorylation	RLADMEHSSGESSFE EHHHCCCCCCCCCCC	27.08	22777824
951	Phosphorylation	LADMEHSSGESSFES HHHCCCCCCCCCCCC	48.78	22777824
954	Phosphorylation	MEHSSGESSFESTGT CCCCCCCCCCCCCCC	43.80	22777824
955	Phosphorylation	EHSSGESSFESTGTG CCCCCCCCCCCCCCC	28.82	22777824
958	Phosphorylation	SGESSFESTGTGLSR CCCCCCCCCCCCCCC	30.08	23090842
959	Phosphorylation	GESSFESTGTGLSRS CCCCCCCCCCCCCCC	31.40	25850435
961	Phosphorylation	SSFESTGTGLSRSPS CCCCCCCCCCCCCCC	34.73	29255136
964	Phosphorylation	ESTGTGLSRSPSQES CCCCCCCCCCCCCCC	31.86	29255136
966	Phosphorylation	TGTGLSRSPSQESNL CCCCCCCCCCCCCCC	26.06	30576142
968	Phosphorylation	TGLSRSPSQESNLSH CCCCCCCCCCCCCCC	48.07	-
974	Phosphorylation	PSQESNLSHSSSFSM CCCCCCCCCCCCCCC	26.10	30576142
980	Phosphorylation	LSHSSSFSMSFEREE CCCCCCCCCEECCHH	18.57	30576142
1031	Phosphorylation	QKEMRRCSSEQMPCP HHHHHCCCCCCCCCC	34.79	23401153
1032	Phosphorylation	KEMRRCSSEQMPCPH HHHHCCCCCCCCCCC	35.16	26657352
1048	Phosphorylation	AEVPEVRSKSFDYGN CCCCCHHCCCCCCCC	37.52	26657352
1050	Phosphorylation	VPEVRSKSFDYGNLS CCCHHCCCCCCCCCC	25.29	23401153
1053	Phosphorylation	VRSKSFDYGNLSHAP HHCCCCCCCCCCCCC	13.10	26657352
1057	Phosphorylation	SFDYGNLSHAPVSGA CCCCCCCCCCCCCCC	22.92	28464451
1062	O-linked_Glycosylation	NLSHAPVSGAAASTV CCCCCCCCCCCCCCC	22.96	31492838
1062	Phosphorylation	NLSHAPVSGAAASTV CCCCCCCCCCCCCCC	22.96	28450419
1067	Phosphorylation	PVSGAAASTVSPSRE CCCCCCCCCCCCCHH	25.31	30576142
1068	Phosphorylation	VSGAAASTVSPSRER CCCCCCCCCCCCHHH	21.92	23927012
1070	Phosphorylation	GAAASTVSPSRERKK CCCCCCCCCCHHHCE	19.76	23927012
1072	Phosphorylation	AASTVSPSRERKKCF CCCCCCCCHHHCEEE	38.99	17081983
1085	Phosphorylation	CFLVRQASFSGSPEI EEEEEEECCCCCCCC	16.17	27273156
1087	Phosphorylation	LVRQASFSGSPEISQ EEEEECCCCCCCCCC	35.55	22199227
1089	Phosphorylation	RQASFSGSPEISQGE EEECCCCCCCCCCCC	20.40	23403867
1093	Phosphorylation	FSGSPEISQGEVGMD CCCCCCCCCCCCCCC	30.39	20639409
1163	Phosphorylation	PQIMHMDSQESLRNP CEEECCCCHHHHHCC	28.42	28348404
1166	Phosphorylation	MHMDSQESLRNPLIQ ECCCCHHHHHCCCCC	25.62	28348404
1267	Ubiquitination	VAEHTGKKPAEYAHT HHHHCCCCCHHHCCC	51.29	29967540
1275	Ubiquitination	PAEYAHTKEQTYPCY CHHHCCCCCCCCCCC	37.65	29967540
1278	O-linked_Glycosylation	YAHTKEQTYPCYSGA HCCCCCCCCCCCCCC	30.44	31492838
1283	O-linked_Glycosylation	EQTYPCYSGASGLHP CCCCCCCCCCCCCCH	34.30	31492838
1286	O-linked_Glycosylation	YPCYSGASGLHPKNL CCCCCCCCCCCHHCC	45.47	31492838
1291	Ubiquitination	GASGLHPKNLLPKFP CCCCCCHHCCCCCCC	49.86	29967540
1296	Ubiquitination	HPKNLLPKFPSDQSS CHHCCCCCCCCCCCC	70.63	29967540
1299	Phosphorylation	NLLPKFPSDQSSKST CCCCCCCCCCCCCCC	51.95	24719451
1320	O-linked_Glycosylation	VLQEDFASANAGSLQ HHHHHHHHCCCCCCC	23.27	31492838
1325	O-linked_Glycosylation	FASANAGSLQSLPGT HHHCCCCCCCCCCCC	22.33	31492838
1328	O-linked_Glycosylation	ANAGSLQSLPGTVVP CCCCCCCCCCCCEEE	41.65	31492838
1377	O-linked_Glycosylation	DENMTQRTLVTNAAM CCCCCHHHHHHHHHH	18.76	31492838
1380	O-linked_Glycosylation	MTQRTLVTNAAMQGI CCHHHHHHHHHHHCC	23.42	31492838
1443	Phosphorylation	GGSKRMLSPASSLEL CCCHHCCCCHHHHHH	14.74	29255136
1446	Phosphorylation	KRMLSPASSLELFME HHCCCCHHHHHHHHH	38.55	29255136
1447	Phosphorylation	RMLSPASSLELFMET HCCCCHHHHHHHHHH	28.15	29255136
1454	Phosphorylation	SLELFMETKQQKRVK HHHHHHHHHHHHHHH	23.51	22199227
1455	Ubiquitination	LELFMETKQQKRVKE HHHHHHHHHHHHHHH	37.11	29967540
1502	Phosphorylation	LVRQGCASEPKDGLQ HHHCCCCCCCCCCCC	59.51	28348404
1540	Phosphorylation	SREPFLPSKEMLSGS CCCCCCCCHHHHCCC	43.31	24719451
1579	Phosphorylation	DETASDMSMSPQSSS CCHHHCCCCCCCCCC	22.54	-
1586	Phosphorylation	SMSPQSSSLPAGDGQ CCCCCCCCCCCCCCC	43.55	-
1613	Phosphorylation	GMLVRMASAPSGNVA HHEEECCCCCCCCCC	31.22	27422710
1616	Phosphorylation	VRMASAPSGNVADST EECCCCCCCCCCCCE	42.59	24719451
1666	Methylation	YVQQATFKSSVYASW CEEEEEECCCEEHHH	37.15	6570115
1717	Ubiquitination	MHRPGTGKLTSSSAW HCCCCCCCCCCHHHH	48.72	29967540
1725	Ubiquitination	LTSSSAWKQFTQMKP CCCHHHHHHHHHCCC	34.94	29967540
1728	Phosphorylation	SSAWKQFTQMKPDAS HHHHHHHHHCCCCHH	25.84	28258704
1731	Ubiquitination	WKQFTQMKPDASFLF HHHHHHCCCCHHHHC	29.90	29967540
1741	Ubiquitination	ASFLFGSKLERKLVG HHHHCCHHHHHHHHH	55.54	29967540
1745	Ubiquitination	FGSKLERKLVGNILK CCHHHHHHHHHHHHH	37.84	29967540
1752	Ubiquitination	KLVGNILKERGKGDI HHHHHHHHHHCCCCC	41.38	29967540
1768	Ubiquitination	GDKDIGSKQTEPIRI CCCCCCCCCCCCEEE	56.90	29967540
1770	Phosphorylation	KDIGSKQTEPIRIKI CCCCCCCCCCEEEEE	47.68	24719451
1782	Phosphorylation	IKIFEGGYKSNEDYV EEEEECCCCCCCCEE	23.31	22817900
1783	Ubiquitination	KIFEGGYKSNEDYVY EEEECCCCCCCCEEE	50.51	29967540
1784	Phosphorylation	IFEGGYKSNEDYVYV EEECCCCCCCCEEEE	36.65	23186163
1788	Phosphorylation	GYKSNEDYVYVRGRG CCCCCCCEEEECCCC	6.36	28796482
1790	Phosphorylation	KSNEDYVYVRGRGRG CCCCCEEEECCCCCC	4.34	28796482
1798	Ubiquitination	VRGRGRGKYICEECG ECCCCCCCEEHHHCC	30.04	-
1812	Phosphorylation	GIRCKKPSMLKKHIR CCCCCCHHHHHHHHH	45.70	22210691
1820	Phosphorylation	MLKKHIRTHTDVRPY HHHHHHHHCCCHHHH	28.64	-
1822	Phosphorylation	KKHIRTHTDVRPYVC HHHHHHCCCHHHHHH	35.26	-
1863	Phosphorylation	LELGVSMTSVDDTET HHHCCCCEECCCCCC	20.35	28348404
1864	Phosphorylation	ELGVSMTSVDDTETE HHCCCCEECCCCCCH	18.20	28348404
1868	Phosphorylation	SMTSVDDTETEEAEN CCEECCCCCCHHHHC	40.10	28348404
1870	Phosphorylation	TSVDDTETEEAENLE EECCCCCCHHHHCHH	41.01	28348404
1935	Phosphorylation	TPKTRSRSTSPQPPR CCCCCCCCCCCCCCC	34.19	28634120
1936	Phosphorylation	PKTRSRSTSPQPPRF CCCCCCCCCCCCCCC	43.23	23312004
1937	Phosphorylation	KTRSRSTSPQPPRFS CCCCCCCCCCCCCCC	23.84	23312004
1945	O-linked_Glycosylation	PQPPRFSSLPVNVGA CCCCCCCCCCCCCCC	33.70	31492838
1961	O-linked_Glycosylation	PHGVPSDSSLGHSSL CCCCCCCCCCCCHHH	31.62	31492838
1974	O-linked_Glycosylation	SLISYLVTLPSIRVT HHHHHHHHCCCCEEE	30.29	31492838
1977	O-linked_Glycosylation	SYLVTLPSIRVTQLM HHHHHCCCCEEEECC	26.58	31492838
1977	Phosphorylation	SYLVTLPSIRVTQLM HHHHHCCCCEEEECC	26.58	24719451
1981	Phosphorylation	TLPSIRVTQLMTPSD HCCCCEEEECCCCCC	13.21	29116813
1985	Phosphorylation	IRVTQLMTPSDSCED CEEEECCCCCCCCCC	28.38	18491316
1987	Phosphorylation	VTQLMTPSDSCEDTQ EEECCCCCCCCCCHH	32.75	18491316
1989	Phosphorylation	QLMTPSDSCEDTQMT ECCCCCCCCCCHHCH	24.60	28348404
1996	Phosphorylation	SCEDTQMTEYQRLFQ CCCCHHCHHHHHHHH	23.02	18491316
1998	Phosphorylation	EDTQMTEYQRLFQSK CCHHCHHHHHHHHCC	6.97	18491316
2004	Phosphorylation	EYQRLFQSKSTDSEP HHHHHHHCCCCCCCC	22.65	23090842
2006	Phosphorylation	QRLFQSKSTDSEPDK HHHHHCCCCCCCCCH	42.57	23090842
2007	Phosphorylation	RLFQSKSTDSEPDKD HHHHCCCCCCCCCHH	47.48	23090842
2009	Phosphorylation	FQSKSTDSEPDKDRL HHCCCCCCCCCHHCC	51.63	23090842
2030	Phosphorylation	DEECMLPSEPSSSPR CCCCCCCCCCCCCCC	59.17	27732954
2033	Phosphorylation	CMLPSEPSSSPRDFS CCCCCCCCCCCCCCC	39.12	27732954
2034	Phosphorylation	MLPSEPSSSPRDFSP CCCCCCCCCCCCCCC	55.89	27732954
2035	Phosphorylation	LPSEPSSSPRDFSPS CCCCCCCCCCCCCCC	28.43	27732954
2040	Phosphorylation	SSSPRDFSPSSHHSS CCCCCCCCCCCCCCC	28.32	20873877
2042	Phosphorylation	SPRDFSPSSHHSSPG CCCCCCCCCCCCCCC	40.90	20873877
2043	Phosphorylation	PRDFSPSSHHSSPGY CCCCCCCCCCCCCCC	28.71	20873877
2059	Phosphorylation	SSPCRDNSPKRYLIP CCCCCCCCCCCEEEC	35.77	30576142
2071	Phosphorylation	LIPKGDLSPRRHLSP EECCCCCCCCCCCCC	22.54	17924679
2077	Phosphorylation	LSPRRHLSPRRDLSP CCCCCCCCCCCCCCC	15.38	17924679
2083	Phosphorylation	LSPRRDLSPMRHLSP CCCCCCCCCCCCCCH	22.42	27422710
2092	Ubiquitination	MRHLSPRKEAALRRE CCCCCHHHHHHHHHH	55.90	21906983
2112	Phosphorylation	VSPRRHLSPRRPVSP CCCCCCCCCCCCCCC	15.38	-
2118	Phosphorylation	LSPRRPVSPGKDITA CCCCCCCCCCCCCCC	30.53	29255136
2124	Phosphorylation	VSPGKDITARRDLSP CCCCCCCCCCCCCCH	25.01	23927012
2130	Phosphorylation	ITARRDLSPRRERRY CCCCCCCCHHHHHHH	22.20	30278072
2137	Phosphorylation	SPRRERRYMTTIRAP CHHHHHHHEEEEECC	12.68	22817900
2157	O-linked_Glycosylation	LYHNPPLSMGQYLQA CCCCCCCCHHHHCCC	27.00	31492838
2270	Phosphorylation	KKGASGESFSKDPYV CCCCCCCCCCCCCCC	38.04	24719451
2273	Ubiquitination	ASGESFSKDPYVLSK CCCCCCCCCCCCCCH	61.79	23503661
2276	Phosphorylation	ESFSKDPYVLSKQHE CCCCCCCCCCCHHHH	24.94	27642862
2292	Phosphorylation	RGPHALQSSGPPSTP CCCCHHHCCCCCCCC	37.81	23927012
2293	Phosphorylation	GPHALQSSGPPSTPS CCCHHHCCCCCCCCC	42.21	23927012
2297	Phosphorylation	LQSSGPPSTPSSPRL HHCCCCCCCCCCCCE	56.96	23401153
2298	Phosphorylation	QSSGPPSTPSSPRLL HCCCCCCCCCCCCEE	32.72	23927012
2300	Phosphorylation	SGPPSTPSSPRLLMK CCCCCCCCCCCEECC	53.73	23401153
2301	Phosphorylation	GPPSTPSSPRLLMKQ CCCCCCCCCCEECCC	18.42	25159151
2309	Phosphorylation	PRLLMKQSTSEDSLN CCEECCCCCCHHHCC	28.51	23090842
2310	Phosphorylation	RLLMKQSTSEDSLNA CEECCCCCCHHHCCH	33.37	23401153
2311	Phosphorylation	LLMKQSTSEDSLNAT EECCCCCCHHHCCHH	44.65	28985074
2314	Phosphorylation	KQSTSEDSLNATERE CCCCCHHHCCHHHHH	21.33	23090842
2318	Phosphorylation	SEDSLNATEREQEEN CHHHCCHHHHHHHHH	34.21	23090842
2328	Phosphorylation	EQEENIQTCTKAIAS HHHHHHHHHHHHHHH	20.53	23312004
2330	Phosphorylation	EENIQTCTKAIASLR HHHHHHHHHHHHHHH	27.22	23312004
2331	Acetylation	ENIQTCTKAIASLRI HHHHHHHHHHHHHHH	39.69	18527709
2364	Phosphorylation	PHQNPLGSAHVSIRH CCCCCCCCCEEEEEC	23.92	23401153
2368	Phosphorylation	PLGSAHVSIRHFSRP CCCCCEEEEECCCCC	12.21	28857561
2373	Phosphorylation	HVSIRHFSRPEPGQP EEEEECCCCCCCCCC	40.58	28348404
2400	Phosphorylation	EKDNFGTSQTPLAHS CCCCCCCCCCCCCCC	32.22	28555341
2402	Phosphorylation	DNFGTSQTPLAHSTF CCCCCCCCCCCCCCE	21.75	25159151
2424	Phosphorylation	DKQLDFHSSKELSSS HHHCCCCCCCHHCCC	43.00	28348404
2425	Phosphorylation	KQLDFHSSKELSSST HHCCCCCCCHHCCCC	22.91	28348404
2429	Phosphorylation	FHSSKELSSSTEESK CCCCCHHCCCCCCCC	24.27	30177828
2430	Phosphorylation	HSSKELSSSTEESKD CCCCHHCCCCCCCCC	54.63	28348404
2431	Phosphorylation	SSKELSSSTEESKDP CCCHHCCCCCCCCCC	36.14	21815630
2432	Phosphorylation	SKELSSSTEESKDPS CCHHCCCCCCCCCCC	45.80	28348404
2435	Phosphorylation	LSSSTEESKDPSSEK HCCCCCCCCCCCCHH	35.81	30177828
2440	Phosphorylation	EESKDPSSEKSQLH- CCCCCCCCHHHCCC-	55.20	-
2443	Phosphorylation	KDPSSEKSQLH---- CCCCCHHHCCC----	33.64	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ZEP2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZEP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZEP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ZEP2_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZEP2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2071 AND SER-2077, ANDMASS SPECTROMETRY.	17924679 [Abstract]
Ubiquitylation
Reference	PubMed
"Tryptic digestion of ubiquitin standards reveals an improved strategyfor identifying ubiquitinated proteins by mass spectrometry."; Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.; Proteomics 7:868-874(2007). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-2092, AND MASSSPECTROMETRY.	17370265 [Abstract]