LIPS_HUMAN - dbPTM
LIPS_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LIPS_HUMAN
UniProt AC Q05469
Protein Name Hormone-sensitive lipase
Gene Name LIPE
Organism Homo sapiens (Human).
Sequence Length 1076
Subcellular Localization Cell membrane. Membrane, caveola. Cytoplasm, cytosol. Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation.
Protein Description In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production..
Protein Sequence MEPGSKSVSRSDWQPEPHQRPITPLEPGPEKTPIAQPESKTLQGSNTQQKPASNQRPLTQQETPAQHDAESQKEPRAQQKSASQEEFLAPQKPAPQQSPYIQRVLLTQQEAASQQGPGLGKESITQQEPALRQRHVAQPGPGPGEPPPAQQEAESTPAAQAKPGAKREPSAPTESTSQETPEQSDKQTTPVQGAKSKQGSLTELGFLTKLQELSIQRSALEWKALSEWVTDSESESDVGSSSDTDSPATMGGMVAQGVKLGFKGKSGYKVMSGYSGTSPHEKTSARNHRHYQDTASRLIHNMDLRTMTQSLVTLAEDNIAFFSSQGPGETAQRLSGVFAGVREQALGLEPALGRLLGVAHLFDLDPETPANGYRSLVHTARCCLAHLLHKSRYVASNRRSIFFRTSHNLAELEAYLAALTQLRALVYYAQRLLVTNRPGVLFFEGDEGLTADFLREYVTLHKGCFYGRCLGFQFTPAIRPFLQTISIGLVSFGEHYKRNETGLSVAASSLFTSGRFAIDPELRGAEFERITQNLDVHFWKAFWNITEMEVLSSLANMASATVRVSRLLSLPPEAFEMPLTADPTLTVTISPPLAHTGPGPVLVRLISYDLREGQDSEELSSLIKSNGQRSLELWPRPQQAPRSRSLIVHFHGGGFVAQTSRSHEPYLKSWAQELGAPIISIDYSLAPEAPFPRALEECFFAYCWAIKHCALLGSTGERICLAGDSAGGNLCFTVALRAAAYGVRVPDGIMAAYPATMLQPAASPSRLLSLMDPLLPLSVLSKCVSAYAGAKTEDHSNSDQKALGMMGLVRRDTALLLRDFRLGASSWLNSFLELSGRKSQKMSEPIAEPMRRSVSEAALAQPQGPLGTDSLKNLTLRDLSLRGNSETSSDTPEMSLSAETLSPSTPSDVNFLLPPEDAGEEAEAKNELSPMDRGLGVRAAFPEGFHPRRSSQGATQMPLYSSPIVKNPFMSPLLAPDSMLKSLPPVHIVACALDPMLDDSVMLARRLRNLGQPVTLRVVEDLPHGFLTLAALCRETRQAAELCVERIRLVLTPPAGAGPSGETGAAGVDGGCGGRH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
188PhosphorylationPEQSDKQTTPVQGAK
CCCCCCCCCCCCCCC		38.5220230923
189PhosphorylationEQSDKQTTPVQGAKS
CCCCCCCCCCCCCCC		20.9720230923
196PhosphorylationTPVQGAKSKQGSLTE
CCCCCCCCCCCCHHH		29.6722817900
200PhosphorylationGAKSKQGSLTELGFL
CCCCCCCCHHHHHHH		29.6230622161
202PhosphorylationKSKQGSLTELGFLTK
CCCCCCHHHHHHHHH		30.7530622161
214PhosphorylationLTKLQELSIQRSALE
HHHHHHHHHCHHHHH		18.8724719451
218PhosphorylationQELSIQRSALEWKAL
HHHHHCHHHHHHHHH		22.3430622161
323 (in isoform 2)Ubiquitination-18.4621906983
400PhosphorylationYVASNRRSIFFRTSH
HHHHCCCEEEEECCC		22.1022210691
405PhosphorylationRRSIFFRTSHNLAEL
CCEEEEECCCCHHHH		29.2222210691
504PhosphorylationKRNETGLSVAASSLF
CCCCCCCHHHHHHHH		15.8525693802
508PhosphorylationTGLSVAASSLFTSGR
CCCHHHHHHHHHCCC		20.1725693802
509PhosphorylationGLSVAASSLFTSGRF
CCHHHHHHHHHCCCE		23.8325693802
552 (in isoform 2)Phosphorylation-28.60-
565PhosphorylationASATVRVSRLLSLPP
HHCCHHHHHHHCCCH		13.4716188906
607PhosphorylationPVLVRLISYDLREGQ
CEEEEEEEEECCCCC		19.7229449344
608PhosphorylationVLVRLISYDLREGQD
EEEEEEEEECCCCCC		16.4129449344
621PhosphorylationQDSEELSSLIKSNGQ
CCHHHHHHHHHHCCC		46.9024719451
624 (in isoform 1)Ubiquitination-43.0621906983
624UbiquitinationEELSSLIKSNGQRSL
HHHHHHHHHCCCCCC		43.062190698
630PhosphorylationIKSNGQRSLELWPRP
HHHCCCCCCEECCCC		20.5024719451
645PhosphorylationQQAPRSRSLIVHFHG
CCCCCCCEEEEEEEC		24.56-
741PhosphorylationVALRAAAYGVRVPDG
HHHHHHHHCCCCCCC		16.07-
813PhosphorylationMGLVRRDTALLLRDF
HHHHHHHHHHHHHHH		19.8624670416
825PhosphorylationRDFRLGASSWLNSFL
HHHHHCHHHHHHHHH		21.9027251275
835PhosphorylationLNSFLELSGRKSQKM
HHHHHHHCCCCCCCC		27.4627251275
853PhosphorylationIAEPMRRSVSEAALA
CCHHHHHHHHHHHHC		21.4529255136
855PhosphorylationEPMRRSVSEAALAQP
HHHHHHHHHHHHCCC		23.8229255136
868PhosphorylationQPQGPLGTDSLKNLT
CCCCCCCCHHHHCCC		30.0523403867
870PhosphorylationQGPLGTDSLKNLTLR
CCCCCCHHHHCCCHH		40.8723403867
872UbiquitinationPLGTDSLKNLTLRDL
CCCCHHHHCCCHHHH		54.59-
875PhosphorylationTDSLKNLTLRDLSLR
CHHHHCCCHHHHHHC		29.1924719451
880PhosphorylationNLTLRDLSLRGNSET
CCCHHHHHHCCCCCC		21.9524719451
891PhosphorylationNSETSSDTPEMSLSA
CCCCCCCCCCCCEEE		24.0927251275
895PhosphorylationSSDTPEMSLSAETLS
CCCCCCCCEEECCCC		19.9428348404
897PhosphorylationDTPEMSLSAETLSPS
CCCCCCEEECCCCCC		19.4228348404
900PhosphorylationEMSLSAETLSPSTPS
CCCEEECCCCCCCCC		32.0528348404
902PhosphorylationSLSAETLSPSTPSDV
CEEECCCCCCCCCCC		24.9928348404
904PhosphorylationSAETLSPSTPSDVNF
EECCCCCCCCCCCCC		49.9628348404
905PhosphorylationAETLSPSTPSDVNFL
ECCCCCCCCCCCCCC		30.1428348404
929PhosphorylationAEAKNELSPMDRGLG
HHHHHCCCCCCCCCC		16.4023882029
950PhosphorylationEGFHPRRSSQGATQM
CCCCCCCCCCCCCCC		28.4321945579
951PhosphorylationGFHPRRSSQGATQMP
CCCCCCCCCCCCCCC		30.7121945579
955PhosphorylationRRSSQGATQMPLYSS
CCCCCCCCCCCCCCC		32.0221945579
960PhosphorylationGATQMPLYSSPIVKN
CCCCCCCCCCCCCCC		10.9623663014
961PhosphorylationATQMPLYSSPIVKNP
CCCCCCCCCCCCCCC		37.0023663014
962PhosphorylationTQMPLYSSPIVKNPF
CCCCCCCCCCCCCCC		12.7021945579
1015PhosphorylationRNLGQPVTLRVVEDL
HHCCCCEEEEEECCC		18.61-
1052PhosphorylationERIRLVLTPPAGAGP
HHEEEEEECCCCCCC		21.5328674151
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
552SPhosphorylationKinasePKA-FAMILY-GPS
554SPhosphorylationKinasePKA-FAMILY-GPS
649SPhosphorylationKinasePKA-FAMILY-GPS
650SPhosphorylationKinasePKA-FAMILY-GPS
853SPhosphorylationKinasePKACAP17612
PSP
853SPhosphorylationKinasePKA_GROUP-PhosphoELM
853SPhosphorylationKinasePRKACAP05132
GPS
853SPhosphorylationKinasePKA-FAMILY-GPS
853SPhosphorylationKinasePRKG1Q13976
GPS
855SPhosphorylationKinasePRKAA1Q13131
GPS
855SPhosphorylationKinasePKA_GROUP-PhosphoELM
855SPhosphorylationKinaseAMPK_GROUP-PhosphoELM
855SPhosphorylationKinasePKA-FAMILY-GPS
855SPhosphorylationKinaseAMPK-FAMILY-GPS
855SPhosphorylationKinaseCAMK1Q14012
GPS
855SPhosphorylationKinasePRKACAP05132
GPS
855SPhosphorylationKinaseAMPKQ9Y478
Uniprot
950SPhosphorylationKinasePKA-FAMILY-GPS
950SPhosphorylationKinasePKA_GROUP-PhosphoELM
950SPhosphorylationKinasePRKACAP05132
GPS
951SPhosphorylationKinasePKA-FAMILY-GPS
951SPhosphorylationKinasePRKACAP05132
GPS
951SPhosphorylationKinasePKA_GROUP-PhosphoELM
951SPhosphorylationKinasePKACAP17612
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LIPS_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LIPS_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CAVN1_HUMANPTRFphysical
17026959
PLIN1_HUMANPLIN1physical
17189257
FABP4_HUMANFABP4physical
17785468
PLIN1_HUMANPLIN1physical
19717842
PLIN5_HUMANPLIN5physical
19717842
PLIN2_HUMANPLIN2physical
19717842
PLIN3_HUMANPLIN3physical
19717842
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615980Lipodystrophy, familial partial, 6 (FPLD6)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LIPS_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-196, AND MASSSPECTROMETRY.

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