PLIN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLIN1_HUMAN
• UniProt AC: O60240
• Protein Name: Perilipin-1
• Gene Name: PLIN1
• Organism: Homo sapiens (Human).
• Sequence Length: 522
• Subcellular Localization: Endoplasmic reticulum . Lipid droplet . Lipid droplet surface-associated.
• Protein Description: Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels..
• Protein Sequence: MAVNKGLTLLDGDLPEQENVLQRVLQLPVVSGTCECFQKTYTSTKEAHPLVASVCNAYEKGVQSASSLAAWSMEPVVRRLSTQFTAANELACRGLDHLEEKIPALQYPPEKIASELKDTISTRLRSARNSISVPIASTSDKVLGAALAGCELAWGVARDTAEFAANTRAGRLASGGADLALGSIEKVVEYLLPPDKEESAPAPGHQQAQKSPKAKPSLLSRVGALTNTLSRYTVQTMARALEQGHTVAMWIPGVVPLSSLAQWGASVAMQAVSRRRSEVRVPWLHSLAAAQEEDHEDQTDTEGEDTEEEEELETEENKFSEVAALPGPRGLLGGVAHTLQKTLQTTISAVTWAPAAVLGMAGRVLHLTPAPAVSSTKGRAMSLSDALKGVTDNVVDTVVHYVPLPRLSLMEPESEFRDIDNPPAEVERREAERRASGAPSAGPEPAPRLAQPRRSLRSAQSPGAPPGPGLEDEVATPAAPRPGFPAVPREKPKRRVSDSFFRPSVMEPILGRTHYSQLRKKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MAVNKGLTLLDGDLP CCCCCCCEECCCCCH	33.66	24719451
31	Phosphorylation	VLQLPVVSGTCECFQ HHHCCCCCCEEHHHH	28.72	27251275
33	Phosphorylation	QLPVVSGTCECFQKT HCCCCCCEEHHHHHH	9.53	27251275
40	Phosphorylation	TCECFQKTYTSTKEA EEHHHHHHCCCCCCC	22.65	-
53	Phosphorylation	EAHPLVASVCNAYEK CCCHHHHHHHHHHHH	21.52	27251275
58	Phosphorylation	VASVCNAYEKGVQSA HHHHHHHHHHHCCCH	12.27	-
64	Phosphorylation	AYEKGVQSASSLAAW HHHHHCCCHHHHHHH	27.93	27251275
66	Phosphorylation	EKGVQSASSLAAWSM HHHCCCHHHHHHHCC	31.00	27251275
67	Phosphorylation	KGVQSASSLAAWSME HHCCCHHHHHHHCCH	23.03	27251275
81	Phosphorylation	EPVVRRLSTQFTAAN HHHHHHHHHHHHHHH	20.53	28258704
82	Phosphorylation	PVVRRLSTQFTAANE HHHHHHHHHHHHHHH	32.09	28857561
85	Phosphorylation	RRLSTQFTAANELAC HHHHHHHHHHHHHHH	18.29	23312004
126	Phosphorylation	TISTRLRSARNSISV HHHHHHHHHHHCCCC	35.85	22777824
130	Phosphorylation	RLRSARNSISVPIAS HHHHHHHCCCCEECC	15.64	28258704
132	Phosphorylation	RSARNSISVPIASTS HHHHHCCCCEECCCC	22.97	25072903
137	Phosphorylation	SISVPIASTSDKVLG CCCCEECCCCHHHHH	29.21	22673903
138	Phosphorylation	ISVPIASTSDKVLGA CCCEECCCCHHHHHH	31.74	22673903
139	Phosphorylation	SVPIASTSDKVLGAA CCEECCCCHHHHHHH	32.70	22673903
174	Phosphorylation	TRAGRLASGGADLAL CHHHHHHHCCCCCCC	42.21	28258704
183	Phosphorylation	GADLALGSIEKVVEY CCCCCCCCHHHHHHH	28.55	27251275
211	Phosphorylation	GHQQAQKSPKAKPSL CCHHHHHCCCCCHHH	21.39	27251275
217	Phosphorylation	KSPKAKPSLLSRVGA HCCCCCHHHHHHHHH	41.03	24719451
220	Phosphorylation	KAKPSLLSRVGALTN CCCHHHHHHHHHHHH	30.16	24719451
232	Phosphorylation	LTNTLSRYTVQTMAR HHHHHHHHHHHHHHH	14.11	23663014
233	Phosphorylation	TNTLSRYTVQTMARA HHHHHHHHHHHHHHH	12.67	23663014
236	Phosphorylation	LSRYTVQTMARALEQ HHHHHHHHHHHHHHC	14.41	23663014
266	O-linked_Glycosylation	SLAQWGASVAMQAVS HHHHHHHHHHHHHHH	13.38	29351928
299	Phosphorylation	EEDHEDQTDTEGEDT HHCCCCCCCCCCCCH	58.15	22817900
301	Phosphorylation	DHEDQTDTEGEDTEE CCCCCCCCCCCCHHH	49.64	22817900
306	Phosphorylation	TDTEGEDTEEEEELE CCCCCCCHHHHHHHH	40.78	22817900
314	Phosphorylation	EEEEELETEENKFSE HHHHHHHHHHHCHHH	62.31	-
374	Phosphorylation	LTPAPAVSSTKGRAM CCCCCCCCCCCCCCC	34.10	27251275
375	Phosphorylation	TPAPAVSSTKGRAMS CCCCCCCCCCCCCCC	27.78	24275569
382	Phosphorylation	STKGRAMSLSDALKG CCCCCCCCHHHHHCC	24.60	28258704
384	Phosphorylation	KGRAMSLSDALKGVT CCCCCCHHHHHCCCC	17.33	22673903
401	Phosphorylation	VVDTVVHYVPLPRLS CCCHHHHCCCCCCCC	7.67	27251275
408	Phosphorylation	YVPLPRLSLMEPESE CCCCCCCCCCCCHHH	27.27	22777824
436	Phosphorylation	REAERRASGAPSAGP HHHHHHHCCCCCCCC	33.41	28258704
440	Phosphorylation	RRASGAPSAGPEPAP HHHCCCCCCCCCCCC	45.37	22985185
458	Phosphorylation	QPRRSLRSAQSPGAP CCHHHHHHCCCCCCC	35.63	28348404
461	Phosphorylation	RSLRSAQSPGAPPGP HHHHHCCCCCCCCCC	25.64	24719451
476	Phosphorylation	GLEDEVATPAAPRPG CCCCCCCCCCCCCCC	20.73	27251275
497	Phosphorylation	EKPKRRVSDSFFRPS CCCCCCCCCCCCCHH	26.23	26657352
499	Phosphorylation	PKRRVSDSFFRPSVM CCCCCCCCCCCHHHH	20.83	22777824
504	Phosphorylation	SDSFFRPSVMEPILG CCCCCCHHHHHHHCC	29.82	23312004
513	Phosphorylation	MEPILGRTHYSQLRK HHHHCCCCCHHHHHH	24.30	27251275
515	Phosphorylation	PILGRTHYSQLRKKS HHCCCCCHHHHHHCC	9.48	-
516	Phosphorylation	ILGRTHYSQLRKKS- HCCCCCHHHHHHCC-	18.35	27251275
522	Phosphorylation	YSQLRKKS------- HHHHHHCC-------	48.79	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	ITCH	Q96J02	PMID:20504295

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLIN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLIN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ABHD5_HUMAN	ABHD5	physical	21757733
PLIN1_HUMAN	PLIN1	physical	17189257
SQSTM_HUMAN	SQSTM1	physical	28951592

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613877: Lipodystrophy, familial partial, 4 (FPLD4)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.