ABHD5_HUMAN - dbPTM
ABHD5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ABHD5_HUMAN
UniProt AC Q8WTS1
Protein Name 1-acylglycerol-3-phosphate O-acyltransferase ABHD5
Gene Name ABHD5
Organism Homo sapiens (Human).
Sequence Length 349
Subcellular Localization Cytoplasm . Lipid droplet. Colocalized with PLIN and ADRP on the surface of lipid droplets. The localization is dependent upon the metabolic status of the adipocytes and the activity of PKA (By similarity)..
Protein Description Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. [PubMed: 18606822 May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2]
Protein Sequence MAAEEEEVDSADTGERSGWLTGWLPTWCPTSISHLKEAEEKMLKCVPCTYKKEPVRISNGNKIWTLKFSHNISNKTPLVLLHGFGGGLGLWALNFGDLCTNRPVYAFDLLGFGRSSRPRFDSDAEEVENQFVESIEEWRCALGLDKMILLGHNLGGFLAAAYSLKYPSRVNHLILVEPWGFPERPDLADQDRPIPVWIRALGAALTPFNPLAGLRIAGPFGLSLVQRLRPDFKRKYSSMFEDDTVTEYIYHCNVQTPSGETAFKNMTIPYGWAKRPMLQRIGKMHPDIPVSVIFGARSCIDGNSGTSIQSLRPHSYVKTIAILGAGHYVYADQPEEFNQKVKEICDTVD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAAEEEEVD
------CCCCHHHCC
24.4722814378
10PhosphorylationAEEEEVDSADTGERS
CCHHHCCCCCCCCCC
32.9723663014
13PhosphorylationEEVDSADTGERSGWL
HHCCCCCCCCCCCCC
40.4323663014
36UbiquitinationPTSISHLKEAEEKML
CCCHHHHHHHHHHHH
49.83-
44UbiquitinationEAEEKMLKCVPCTYK
HHHHHHHCCEECCCC
29.68-
49PhosphorylationMLKCVPCTYKKEPVR
HHCCEECCCCCCCEE
32.1029759185
50PhosphorylationLKCVPCTYKKEPVRI
HCCEECCCCCCCEEE
27.1229759185
62UbiquitinationVRISNGNKIWTLKFS
EEEECCCEEEEEEEC
40.81-
122PhosphorylationSSRPRFDSDAEEVEN
CCCCCCCCCHHHHHH
35.69-
163PhosphorylationGFLAAAYSLKYPSRV
HHHHHHHHCCCCCCC
17.4124719451
223PhosphorylationIAGPFGLSLVQRLRP
ECCHHHHHHHHHHCH
27.2028857561
236PhosphorylationRPDFKRKYSSMFEDD
CHHHHHHHHHHCCCC
15.2650558751
283UbiquitinationPMLQRIGKMHPDIPV
HHHHHHHCCCCCCCE
31.50-
306PhosphorylationCIDGNSGTSIQSLRP
ECCCCCCCCHHHCCC
23.6026437602
310PhosphorylationNSGTSIQSLRPHSYV
CCCCCHHHCCCCCCC
25.3626437602

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ABHD5_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ABHD5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ABHD5_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PLPL2_HUMANPNPLA2physical
23297223
PLIN1_HUMANPLIN1physical
17189257
PLPL2_HUMANPNPLA2physical
17189257
PLIN1_HUMANPLIN1physical
19717842
SKAP2_HUMANSKAP2physical
28514442
TRI59_HUMANTRIM59physical
28514442
SARAF_HUMANSARAFphysical
28514442
TM38B_HUMANTMEM38Bphysical
28514442
RASN_HUMANNRASphysical
28514442
ZPR1_HUMANZPR1physical
28514442
HMOX2_HUMANHMOX2physical
28514442
KDM4A_HUMANKDM4Aphysical
28514442

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ABHD5_HUMAN

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Related Literatures of Post-Translational Modification

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