UniProt ID | ABHD5_HUMAN | |
---|---|---|
UniProt AC | Q8WTS1 | |
Protein Name | 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 | |
Gene Name | ABHD5 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 349 | |
Subcellular Localization | Cytoplasm . Lipid droplet. Colocalized with PLIN and ADRP on the surface of lipid droplets. The localization is dependent upon the metabolic status of the adipocytes and the activity of PKA (By similarity).. | |
Protein Description | Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. [PubMed: 18606822 May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2] | |
Protein Sequence | MAAEEEEVDSADTGERSGWLTGWLPTWCPTSISHLKEAEEKMLKCVPCTYKKEPVRISNGNKIWTLKFSHNISNKTPLVLLHGFGGGLGLWALNFGDLCTNRPVYAFDLLGFGRSSRPRFDSDAEEVENQFVESIEEWRCALGLDKMILLGHNLGGFLAAAYSLKYPSRVNHLILVEPWGFPERPDLADQDRPIPVWIRALGAALTPFNPLAGLRIAGPFGLSLVQRLRPDFKRKYSSMFEDDTVTEYIYHCNVQTPSGETAFKNMTIPYGWAKRPMLQRIGKMHPDIPVSVIFGARSCIDGNSGTSIQSLRPHSYVKTIAILGAGHYVYADQPEEFNQKVKEICDTVD | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
2 | Acetylation | ------MAAEEEEVD ------CCCCHHHCC | 24.47 | 22814378 | |
10 | Phosphorylation | AEEEEVDSADTGERS CCHHHCCCCCCCCCC | 32.97 | 23663014 | |
13 | Phosphorylation | EEVDSADTGERSGWL HHCCCCCCCCCCCCC | 40.43 | 23663014 | |
36 | Ubiquitination | PTSISHLKEAEEKML CCCHHHHHHHHHHHH | 49.83 | - | |
44 | Ubiquitination | EAEEKMLKCVPCTYK HHHHHHHCCEECCCC | 29.68 | - | |
49 | Phosphorylation | MLKCVPCTYKKEPVR HHCCEECCCCCCCEE | 32.10 | 29759185 | |
50 | Phosphorylation | LKCVPCTYKKEPVRI HCCEECCCCCCCEEE | 27.12 | 29759185 | |
62 | Ubiquitination | VRISNGNKIWTLKFS EEEECCCEEEEEEEC | 40.81 | - | |
122 | Phosphorylation | SSRPRFDSDAEEVEN CCCCCCCCCHHHHHH | 35.69 | - | |
163 | Phosphorylation | GFLAAAYSLKYPSRV HHHHHHHHCCCCCCC | 17.41 | 24719451 | |
223 | Phosphorylation | IAGPFGLSLVQRLRP ECCHHHHHHHHHHCH | 27.20 | 28857561 | |
236 | Phosphorylation | RPDFKRKYSSMFEDD CHHHHHHHHHHCCCC | 15.26 | 50558751 | |
283 | Ubiquitination | PMLQRIGKMHPDIPV HHHHHHHCCCCCCCE | 31.50 | - | |
306 | Phosphorylation | CIDGNSGTSIQSLRP ECCCCCCCCHHHCCC | 23.60 | 26437602 | |
310 | Phosphorylation | NSGTSIQSLRPHSYV CCCCCHHHCCCCCCC | 25.36 | 26437602 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ABHD5_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ABHD5_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ABHD5_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
PLPL2_HUMAN | PNPLA2 | physical | 23297223 | |
PLIN1_HUMAN | PLIN1 | physical | 17189257 | |
PLPL2_HUMAN | PNPLA2 | physical | 17189257 | |
PLIN1_HUMAN | PLIN1 | physical | 19717842 | |
SKAP2_HUMAN | SKAP2 | physical | 28514442 | |
TRI59_HUMAN | TRIM59 | physical | 28514442 | |
SARAF_HUMAN | SARAF | physical | 28514442 | |
TM38B_HUMAN | TMEM38B | physical | 28514442 | |
RASN_HUMAN | NRAS | physical | 28514442 | |
ZPR1_HUMAN | ZPR1 | physical | 28514442 | |
HMOX2_HUMAN | HMOX2 | physical | 28514442 | |
KDM4A_HUMAN | KDM4A | physical | 28514442 |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
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