PLIN2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLIN2_HUMAN
• UniProt AC: Q99541
• Protein Name: Perilipin-2
• Gene Name: PLIN2
• Organism: Homo sapiens (Human).
• Sequence Length: 437
• Subcellular Localization: Membrane ; Peripheral membrane protein . Lipid droplet .
• Protein Description: May be involved in development and maintenance of adipose tissue..
• Protein Sequence: MASVAVDPQPSVVTRVVNLPLVSSTYDLMSSAYLSTKDQYPYLKSVCEMAENGVKTITSVAMTSALPIIQKLEPQIAVANTYACKGLDRIEERLPILNQPSTQIVANAKGAVTGAKDAVTTTVTGAKDSVASTITGVMDKTKGAVTGSVEKTKSVVSGSINTVLGSRMMQLVSSGVENALTKSELLVEQYLPLTEEELEKEAKKVEGFDLVQKPSYYVRLGSLSTKLHSRAYQQALSRVKEAKQKSQQTISQLHSTVHLIEFARKNVYSANQKIQDAQDKLYLSWVEWKRSIGYDDTDESHCAEHIESRTLAIARNLTQQLQTTCHTLLSNIQGVPQNIQDQAKHMGVMAGDIYSVFRNAASFKEVSDSLLTSSKGQLQKMKESLDDVMDYLVNNTPLNWLVGPFYPQLTESQNAQDQGAEMDKSSQETQRSEHKTH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASVAVDPQ ------CCCCCCCCC	16.83	22223895
23	Phosphorylation	VVNLPLVSSTYDLMS EECCCCEECHHHHHH	25.33	27251275
24	Phosphorylation	VNLPLVSSTYDLMSS ECCCCEECHHHHHHH	24.41	27251275
25	Phosphorylation	NLPLVSSTYDLMSSA CCCCEECHHHHHHHH	17.35	27251275
26	Phosphorylation	LPLVSSTYDLMSSAY CCCEECHHHHHHHHH	14.72	27251275
40	Phosphorylation	YLSTKDQYPYLKSVC HCCCCHHCHHHHHHH	12.18	28102081
42	Phosphorylation	STKDQYPYLKSVCEM CCCHHCHHHHHHHHH	23.10	28102081
56	Phosphorylation	MAENGVKTITSVAMT HHHCCCCHHHHHHHH	27.38	28796482
58	Phosphorylation	ENGVKTITSVAMTSA HCCCCHHHHHHHHHH	23.52	28796482
59	Phosphorylation	NGVKTITSVAMTSAL CCCCHHHHHHHHHHH	12.20	28796482
63	Phosphorylation	TITSVAMTSALPIIQ HHHHHHHHHHHHHHH	10.91	28796482
64	Phosphorylation	ITSVAMTSALPIIQK HHHHHHHHHHHHHHH	18.09	28796482
116	Ubiquitination	KGAVTGAKDAVTTTV CCCCCCCCCCEEEEC	47.79	-
129	Phosphorylation	TVTGAKDSVASTITG ECCCCHHHHHHHHHH	20.90	28509920
132	Phosphorylation	GAKDSVASTITGVMD CCHHHHHHHHHHCCC	20.42	28509920
133	Phosphorylation	AKDSVASTITGVMDK CHHHHHHHHHHCCCC	16.90	28509920
135	Phosphorylation	DSVASTITGVMDKTK HHHHHHHHHCCCCCC	24.66	28509920
140	Ubiquitination	TITGVMDKTKGAVTG HHHHCCCCCCCCCCC	33.76	21906983
140	2-Hydroxyisobutyrylation	TITGVMDKTKGAVTG HHHHCCCCCCCCCCC	33.76	-
148	Phosphorylation	TKGAVTGSVEKTKSV CCCCCCCCEECCHHH	20.10	25159151
151	2-Hydroxyisobutyrylation	AVTGSVEKTKSVVSG CCCCCEECCHHHHHC	60.13	-
153	Ubiquitination	TGSVEKTKSVVSGSI CCCEECCHHHHHCCH	52.93	-
154	Phosphorylation	GSVEKTKSVVSGSIN CCEECCHHHHHCCHH	32.74	28857561
159	Phosphorylation	TKSVVSGSINTVLGS CHHHHHCCHHHHHHH	12.73	28857561
166	Phosphorylation	SINTVLGSRMMQLVS CHHHHHHHHHHHHHH	16.91	28857561
190	Phosphorylation	SELLVEQYLPLTEEE HHHHHHHHCCCCHHH	9.22	28851738
194	Phosphorylation	VEQYLPLTEEELEKE HHHHCCCCHHHHHHH	39.14	28851738
215	Phosphorylation	FDLVQKPSYYVRLGS CCCCCCCCEEEECCC	35.81	23401153
216	Phosphorylation	DLVQKPSYYVRLGSL CCCCCCCEEEECCCH	17.95	28857561
217	Phosphorylation	LVQKPSYYVRLGSLS CCCCCCEEEECCCHH	5.39	28857561
222	Phosphorylation	SYYVRLGSLSTKLHS CEEEECCCHHHHHHH	24.60	23401153
224	Phosphorylation	YVRLGSLSTKLHSRA EEECCCHHHHHHHHH	25.78	28857561
225	Phosphorylation	VRLGSLSTKLHSRAY EECCCHHHHHHHHHH	42.81	30576142
237	Phosphorylation	RAYQQALSRVKEAKQ HHHHHHHHHHHHHHH	37.73	27251275
251	Phosphorylation	QKSQQTISQLHSTVH HHHHHHHHHHHHHHH	30.03	25072903
255	Phosphorylation	QTISQLHSTVHLIEF HHHHHHHHHHHHHHH	40.49	28857561
256	Phosphorylation	TISQLHSTVHLIEFA HHHHHHHHHHHHHHH	10.95	25072903
273	Ubiquitination	NVYSANQKIQDAQDK HCCCHHHHHHHHHHH	41.99	-
291	Phosphorylation	SWVEWKRSIGYDDTD HHHHHHHHCCCCCCC	19.35	27251275
300	Phosphorylation	GYDDTDESHCAEHIE CCCCCCHHHHHHHHH	27.03	28555341
362	Phosphorylation	SVFRNAASFKEVSDS HHHHCCCCHHHHHHH	34.15	28450419
375	Ubiquitination	DSLLTSSKGQLQKMK HHHHHCCHHHHHHHH	50.90	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	ITCH	Q96J02	PMID:20504295

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLIN2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLIN2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APOB_HUMAN	APOB	physical	22238364

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.