FABP4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FABP4_HUMAN
• UniProt AC: P15090
• Protein Name: Fatty acid-binding protein, adipocyte
• Gene Name: FABP4
• Organism: Homo sapiens (Human).
• Sequence Length: 132
• Subcellular Localization: Cytoplasm . Nucleus . Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export.
• Protein Description: Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus..
• Protein Sequence: MCDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNMIISVNGDVITIKSESTFKNTEISFILGQEFDEVTADDRKVKSTITLDGGVLVHVQKWDGKSTTIKRKREDDKLVVECVMKGVTSTRVYERA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MCDAFVGTW ------CCCCCCEEE	5.34	22223895
8	Phosphorylation	MCDAFVGTWKLVSSE CCCCCCEEEEEECCC	17.71	27251275
13	Phosphorylation	VGTWKLVSSENFDDY CEEEEEECCCCHHHH	42.23	27251275
14	Phosphorylation	GTWKLVSSENFDDYM EEEEEECCCCHHHHH	29.13	27251275
20	Phosphorylation	SSENFDDYMKEVGVG CCCCHHHHHHHHCCC	16.36	8463311
101	Acetylation	HVQKWDGKSTTIKRK EEEECCCCCCEEEEE	42.00	7683607
103	Phosphorylation	QKWDGKSTTIKRKRE EECCCCCCEEEEECC	35.71	-
104	Phosphorylation	KWDGKSTTIKRKRED ECCCCCCEEEEECCC	31.43	-
129	Phosphorylation	GVTSTRVYERA---- CCCCCEEEECC----	9.08	1648089

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
20	Y	Phosphorylation	Kinase	TYR-KINASES	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FABP4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FABP4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
OSTF1_HUMAN	OSTF1	physical	17353931
SYUG_HUMAN	SNCG	physical	17353931
EXT2_HUMAN	EXT2	physical	17353931
VIME_HUMAN	VIM	physical	16169070
ACTB_HUMAN	ACTB	physical	21900206
VIME_HUMAN	VIM	physical	21900206
CHD3_HUMAN	CHD3	physical	21900206
ZBED1_HUMAN	ZBED1	physical	21900206
KPCI_HUMAN	PRKCI	physical	21900206
LIPS_HUMAN	LIPE	physical	15456755

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.