ZDH16_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZDH16_HUMAN
• UniProt AC: Q969W1
• Protein Name: Palmitoyltransferase ZDHHC16 {ECO:0000305}
• Gene Name: ZDHHC16 {ECO:0000312|HGNC:HGNC:20714}
• Organism: Homo sapiens (Human).
• Sequence Length: 377
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6. [PubMed: 28826475 Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization (By similarity Also required for eye development (By similarity Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function]
• Protein Sequence: MRGQRSLLLGPARLCLRLLLLLGYRRRCPPLLRGLVQRWRYGKVCLRSLLYNSFGGSDTAVDAAFEPVYWLVDNVIRWFGVVFVVLVIVLTGSIVAIAYLCVLPLILRTYSVPRLCWHFFYSHWNLILIVFHYYQAITTPPGYPPQGRNDIATVSICKKCIYPKPARTHHCSICNRCVLKMDHHCPWLNNCVGHYNHRYFFSFCFFMTLGCVYCSYGSWDLFREAYAAIEKMKQLDKNKLQAVANQTYHQTPPPTFSFRERMTHKSLVYLWFLCSSVALALGALTVWHAVLISRGETSIERHINKKERRRLQAKGRVFRNPYNYGCLDNWKVFLGVDTGRHWLTRVLLPSSHLPHGNGMSWEPPPWVTAHSASVMAV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	RLLLLLGYRRRCPPL HHHHHHHHHHHCHHH	10.83	18491316
41	Phosphorylation	GLVQRWRYGKVCLRS HHHHHHHHHHHHHHH	17.84	-
43	Ubiquitination	VQRWRYGKVCLRSLL HHHHHHHHHHHHHHH	22.35	-
94 (in isoform 4)	Ubiquitination	-	2.28	-
159	Ubiquitination	ATVSICKKCIYPKPA EEEEEEHHHCCCCCC	22.81	-
251	O-linked_Glycosylation	ANQTYHQTPPPTFSF HHHCCCCCCCCCCCH	25.17	OGP
257	Phosphorylation	QTPPPTFSFRERMTH CCCCCCCCHHHHCCC	26.35	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZDH16_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZDH16_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZDH16_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZDH16_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.