dbPTM

GFPT2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GFPT2_HUMAN
UniProt AC	O94808
Protein Name	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2
Gene Name	GFPT2
Organism	Homo sapiens (Human).
Sequence Length	682
Subcellular Localization
Protein Description	Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins..
Protein Sequence	MCGIFAYMNYRVPRTRKEIFETLIKGLQRLEYRGYDSAGVAIDGNNHEVKERHIQLVKKRGKVKALDEELYKQDSMDLKVEFETHFGIAHTRWATHGVPSAVNSHPQRSDKGNEFVVIHNGIITNYKDLRKFLESKGYEFESETDTETIAKLIKYVFDNRETEDITFSTLVERVIQQLEGAFALVFKSVHYPGEAVATRRGSPLLIGVRSKYKLSTEQIPILYRTCTLENVKNICKTRMKRLDSSACLHAVGDKAVEFFFASDASAIIEHTNRVIFLEDDDIAAVADGKLSIHRVKRSASDDPSRAIQTLQMELQQIMKGNFSAFMQKEIFEQPESVFNTMRGRVNFETNTVLLGGLKDHLKEIRRCRRLIVIGCGTSYHAAVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLLALRYCKDRGALTVGVTNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFISLVMFGLMMSEDRISLQNRRQEIIRGLRSLPELIKEVLSLEEKIHDLALELYTQRSLLVMGRGYNYATCLEGALKIKEITYMHSEGILAGELKHGPLALIDKQMPVIMVIMKDPCFAKCQNALQQVTARQGRPIILCSKDDTESSKFAYKTIELPHTVDCLQGILSVIPLQLLSFHLAVLRGYDVDFPRNLAKSVTVE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	Ubiquitination	DGNNHEVKERHIQLV CCCCHHHHHHHHHHH	46.15	-
64	Ubiquitination	VKKRGKVKALDEELY HHHCCCCHHCCHHHH	46.87	-
75	Phosphorylation	EELYKQDSMDLKVEF HHHHHCCCCCEEEEE	16.23	23828894
100	Phosphorylation	WATHGVPSAVNSHPQ HHHCCCCCHHHCCCC	42.30	-
136	Ubiquitination	LRKFLESKGYEFESE HHHHHHHCCCCCCCC	57.02	-
144	Phosphorylation	GYEFESETDTETIAK CCCCCCCCCHHHHHH	58.46	-
202	Phosphorylation	AVATRRGSPLLIGVR HHHHCCCCCEEEEEE	15.57	30266825
210	Phosphorylation	PLLIGVRSKYKLSTE CEEEEEEECCCCCCC	37.62	20049867
212	Phosphorylation	LIGVRSKYKLSTEQI EEEEEECCCCCCCCC	20.57	20049867
215	Phosphorylation	VRSKYKLSTEQIPIL EEECCCCCCCCCCCE	26.25	28348404
216	Phosphorylation	RSKYKLSTEQIPILY EECCCCCCCCCCCEE	42.20	28348404
227	Phosphorylation	PILYRTCTLENVKNI CCEEEECCHHHHHHH	36.17	28857561
244	Phosphorylation	TRMKRLDSSACLHAV HHHHHCCCCHHHHHH	25.15	29255136
245	Phosphorylation	RMKRLDSSACLHAVG HHHHCCCCHHHHHHC	23.75	30266825
254	Acetylation	CLHAVGDKAVEFFFA HHHHHCHHHHHHHCC	48.69	18586559
328	Ubiquitination	NFSAFMQKEIFEQPE CHHHHHHHHHHHCCH	40.78	21906983
349	Phosphorylation	RGRVNFETNTVLLGG CCCCCCCCCEEEECC	31.86	24043423
351	Phosphorylation	RVNFETNTVLLGGLK CCCCCCCEEEECCHH	21.68	24043423
393	Phosphorylation	RQVLEELTELPVMVE HHHHHHHHCCCHHHH	38.46	20639409
403	Phosphorylation	PVMVELASDFLDRNT CHHHHHHHHHHCCCC	41.33	20639409
444	Phosphorylation	CKDRGALTVGVTNTV HCCCCCEEEEEECCC	18.06	-
450	Phosphorylation	LTVGVTNTVGSSISR EEEEEECCCCCCCCC	19.51	-
453	Phosphorylation	GVTNTVGSSISRETD EEECCCCCCCCCCCC	21.84	-
456	Phosphorylation	NTVGSSISRETDCGV CCCCCCCCCCCCCEE	26.47	-
602	Ubiquitination	MKDPCFAKCQNALQQ ECCHHHHHHHHHHHH	18.99	-
622	Phosphorylation	GRPIILCSKDDTESS CCCEEEEECCCCCCC	35.36	25159151
630	Ubiquitination	KDDTESSKFAYKTIE CCCCCCCCCCHHHCC	43.20	-
677	Ubiquitination	DFPRNLAKSVTVE-- CCCCCHHCCCCCC--	48.93	21906983
677	Acetylation	DFPRNLAKSVTVE-- CCCCCHHCCCCCC--	48.93	21339330
678	Phosphorylation	FPRNLAKSVTVE--- CCCCHHCCCCCC---	19.88	23911959
680	Phosphorylation	RNLAKSVTVE----- CCHHCCCCCC-----	26.47	27134283

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
202	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
202	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GFPT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GFPT2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TCPQ_HUMAN	CCT8	physical	26344197
SYTC2_HUMAN	TARSL2	physical	26344197
GFPT1_HUMAN	GFPT1	physical	28514442
ACOT9_HUMAN	ACOT9	physical	28514442
FIGL1_HUMAN	FIGNL1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00130	L-Glutamine

Regulatory Network of GFPT2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245, AND MASSSPECTROMETRY.	17081983 [Abstract]